Redoxphysiologie

Veröffentlichungen 2023

Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets.
Estela Lorza-Gil, Gabriele Kaiser, Christopher Carlein, Markus  D A Hoffmann, Gabriele M König, Sieglinde Haug, Leticia Prates Roma, Elisabeth Rexen Ulven, Trond Ulven, Evi Kostenis, Andreas L Birkenfeld, Hans-Ulrich Häring, Susanne Ullrich, Felicia Gerst.
Diabetologia. 2023 Aug;66(8):1501-1515. doi: 10.1007/s00125-023-05932-5. Epub 2023 May 23.

Veröffentlichungen 2022

Co-transplantation of pancreatic islets and microvascular fragments effectively restores normoglycemia in diabetic mice
Selina Wrublewsky, Andrea Weinzierl, Isabelle Hornung, Leticia Prates-Roma, Michael D Menger, Matthias W Laschke, Emmanuel Ampofo.
NPJ Regen Med. 2022 Nov 4;7(1):67. doi: 10.1038/s41536-022-00262-3.

Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease.
Julia Wollenhaupt, Janina Frisch, Eva Harlacher, Dickson W L Wong, Han Jin, Corinna Schulte, Sonja Vondenhoff, Julia Moellmann, Barbara Mara Klinkhammer, Li Zhang, Adelina Baleanu-Curaj, Elisa A Liehn, Thimoteus Speer, Andrey Kazakov, Christian Werner, Emiel P C van der Vorst, Simina-Ramona Selejan, Mathias Hohl, Michael Böhm, Rafael Kramann, Erik A L Biessen, Michael Lehrke, Nikolaus Marx, Joachim Jankowski, Christoph Maack, Peter Boor, Leticia Prates Roma, Heidi Noels
Redox Bio. 2022 Oct;56:102459. doi: 10.1016/j.redox.2022.102459. Epub 2022 Aug 30.

Targeting Pancreatic Islet NLRP3 Improves Islet Graft Revascularization.
Selina Wrublewsky, Thimoteus Speer, Lisa Nalbach, Anne S Boewe, Mandy Pack, Dalia Alansary, Leticia P Roma, Markus D A Hoffmann, Beate M Schmitt, Andrea Weinzierl, Michael D Menger, Matthias W Laschke, Emmanuel Ampofo.
Diabetes. 2022 Aug 1;71(8):1706-1720. doi: 10.2337/db21-0851.

Unspecific CTL Killing Is Enhanced by High Glucose via TNF-Related Apoptosis-Inducing Ligand.
Front. Immunol., 21 February 2022, Sec.T Cell Biology
Josefin Soppert, Janina Frisch, Julia Wirth, Christian Hemmers, Peter Boor, Rafael Kramann, Sonja Vondenhoff, Julia Moellmann, Michael Lehrke, Mathias Hohl, Emiel P C van der Vorst, Christian Werner, Thimoteus Speer, Christoph Maack, Nikolaus Marx, Joachim Jankowski, Leticia Prates Roma, Heidi Noels.

Veröffentlichungen 2021

A systematic review and meta-analysis of murine models of uremic cardiomyopathy
Soppert J, Frisch J, Wirth J, Hemmers C, Boor P, Kramann R, Vondenhoff S, Moellmann J, Lehrke M, Hohl M, van der Vorst EPC, Werner C, Speer T, Maack C, Marx M, Jankowski J, Prates Roma L and Noels H.
Kidney Int. 2022 Feb;101(2):256-273. doi: 10.1016/j.kint.2021.10.025

Loss of Mitochondrial Ca2+ Uniporter Limits Inotropic Reserve and Provides Trigger and Substrate for Arrhythmias in Barth Syndrome Cardiomyopathy.
Bertero E, Nickel A, Kohlhaas M, Hohl M, Sequeira V, Brune C, Schwemmlein J, Abeßer M, Schuh K, Kutschka I, Carlein C, Münker K, Atighetchi S, Müller A, Kazakov A, Kappl R, von der Malsburg K, van der Laan M, Schiuma AF, Böhm M, Laufs U, Hoth M, Rehling P, Kuhn M, Dudek J, von der Malsburg A, Prates Roma L, Maack C.
Circulation. 2021 Oct 14. Online ahead of print.

Early Cytokine-Induced Transient NOX2 Activity Is ER Stress-Dependent and Impacts β-Cell Function and Survival.
Vilas-Boas EA, Carlein C, Nalbach L, Almeida DC, Ampofo E, Carpinelli AR, Roma LP*, Ortis F*.
Antioxidants (Basel). 2021 Aug 18;10(8):1305. * shared corresponding author.

Interleukin-1α Is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease.
Schunk SJ, Triem S, Schmit D, Zewinger S, Sarakpi T, Becker E, Hütter G, Wrublewsky S, Küting F, Hohl M, Alansary D, Prates Roma L, Lipp P, Möllmann J, Lehrke M, Laschke MW, Menger MD, Kramann R, Boor P, Jahnen-Dechent W, März W, Böhm M, Laufs U, Niemeyer BA, Fliser D, Ampofo E, Speer T.
Circulation. 2021 Sep 14;144(11):893-908. Epub 2021 Jul 1.

High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity.
Zhu J, Yang W, Zhou X, Zöphel D, Soriano-Baguet L, Dolgener D, Carlein C, Hof C, Zhao R, Ye S, Schwarz EC, Brenner D, Prates Roma L, Qu B.
Front Immunol. 2021 Jun 25;12:689337. doi: 10.3389/fimmu.2021.689337. eCollection 2021. PMID: 34248978 Free PMC article.

Erythropoietin exposure of isolated pancreatic islets accelerates their revascularization after transplantation.
Menger MM,  Nalbach L, Roma LP, Laschke MW, Menger MD, Ampofo E.
Acta Diabetologica. 2021.

Transient NADPH oxidase 2-dependent H2O2 production drives early palmitate-induced lipotoxicity in pancreatic islets.
Vilas-Boas E; Nalbach L; Ampofo E; Lucena CF; Ortis F; Carpinelli AR; Morgan B, Roma LP.
Free Radic Biol Med. 2021 Jan;162:1-13.

Improvement of islet transplantation by the fusion of islet cells with functional blood vessels.
Nalbach L, Roma LP, Schmitt BM, Becker V, Körbel C, Wrublewsky S, Pack M, Später T, Metzger W, Menger MM, Frueh FS, Götz C, Lin H, Em Fox J, MacDonald PE, Menger MD, Laschke MW, Ampofo E.
EMBO Mol Med. 2021 Jan 11;13(1):e12616.

Veröffentlichungen 2020

Evidence for NADPH oxidase activation by GPR40 in pancreatic β-cells.
Nunes Marsiglio-Librais G, Aparecida Vilas-Boas E, Carlein C, Hoffmann MDA, Roma LP*,  Carpinelli AR*. 
Redox Rep. 2020 Dec; 25(1):41-50. * shared corresponding author.

Chronic activation of GPR40 does not negatively impact upon BRIN-BD11 pancreatic β-cell physiology and function.
Vilas-Boas EA, Karabacz N, Marsiglio-Librais GN, Valle MMR, Nalbach L, Ampofo E, Morgan B, Carpinelli AR, Roma LP.
Pharmacol Rep. 2020 Dec;72(6):1725-1737.

Endothelial Notch signaling controls insulin transport in muscle.
Hasan SS, Jabs M, Taylor J, Wiedmann L, Leibing T, Nordström V, Federico G, Roma LP, Carlein C, Wolff G, Ekim-Üstünel B, Brune M, Moll I, Tetzlaff F, Gröne HJ, Fleming T, Géraud C, Herzig S, Nawroth PP, Fischer A.
EMBO Mol Med. 2020 Apr 7;12(4):e09271.

Erythropoietin accelerates the revascularization of transplanted pancreatic islets.
Menger MM, Nalbach L, Roma LP, Körbel C, Wrublewsky S, Glanemann M, Laschke MW, Menger MD, Ampofo E.
Br J Pharmacol. 2020 Apr;177(7):1651-1665.

Nutrient metabolism, subcellular redox state and oxidative stress in pancreatic islets and beta-cells.
Roma LP and Jonas JC.
Journal Molecular Biology. 2020 Mar 6;432 (5):1461-1493.

Veröffentlichungen 2019

STIM-Orai Channels and Reactive Oxygen Species in the Tumor Microenvironment.
Frisch J, Angenendt A, Hoth M, Prates Roma L, Lis A.
Cancers (Basel). 2019 Mar 30;11(4). pii: E457. doi: 10.3390/cancers11040457. Review.

Veröffentlichungen 2018

Glucose acutely reduces cytosolic and mitochondrial H2O2 in rat pancreatic beta-cells.
Deglasse JP, Roma LP, Pastor-Flores D, Gilon P, Dick TP, Jonas JC.
Antioxid Redox Signal. 2018 May 14. doi: 10.1089/ars.2017.7287.

The mitochondrial oxidoreductase CHCHD4 is present in a semi-oxidized state in vivo.
Erdogan E, Ali M, Habich M, Salscheider S, Schu L, Petrungaro C, Roma LP, Riemer J.
Redox Biol. 2018 Mar 24;17:200-206. doi: 10.1016/j.redox.2018.03.014.

The new SFB/TRR219 Research Centre.
Noels H, Boor P, Goettsch C, Hohl M, Jahnen-Dechent W, Jankowski V, Kindermann I, Kramann R, Lehrke M, Linz D, Maack C, Niemeyer B, Roma LP, Schuett K, Speer T, Wagenpfeil S, Werner C, Zewinger S, Böhm M, Marx N, Floege J, Fliser D, Jankowski J.
Eur Heart J. 2018 Mar 21;39(12):975-977. doi:10.1093/eurheartj/ehy083.

Cardiac effects of SGLT2 inhibitors: the sodium hypothesis.
Bertero E, Roma LP, Ameri P, Maack C.
Cardiovasc Res. 2018 Jan 1;114(1):12-18. doi:10.1093/cvr/cvx149.

Veröffentlichungen 2017

Mechanisms and applications of redox-sensitive GFP-based H2O2 probes.
Roma LP*, Deponte M, Riemer J, Morgan B.
Antioxid Redox Signal. 2017 Nov 21. doi: 10.1089/ars.2017.7449. *shared corresponding author

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
Cabezas-Wallscheid N, Buettner F, Klimmeck D, Sommerkamp P, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Scognamiglio R, Zeisberger P, Przybylla A, Altamura S, Florian CM, Fawaz M, Vonficht D, Collier P, Pavlinik D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA, Stegle O, Trumpp A.
Cell. 2017 May 18;169(5):807-823.e19. doi: 10.1016/j.cell.2017.04.018.

NADPH oxidase-2 does not contribute to β-cell glucotoxicity in cultured pancreatic islets from C57BL/6J mice.
de Souza AH, Santos LR, Roma LP, Bensellam M, Carpinelli AR, Jonas JC.
Mol Cell Endocrinol. 2017 Jan 5;439:354-362. doi: 10.1016/j.mce.2016.09.022.

Veröffentlichungen 2016

Mouse redox histology using genetically encoded biosensors.
Fujikawa Y*, Roma LP*, Sobotta MC, Rose AJ, Diaz MB, Locatelli G, Breckwoldt M, Misgeld T, Kerchensteimer M, Herzig S, Muller-Decker K, Dick TP.
Science Signaling. 2016 Mar 15;9(419):rs1. doi: 10.1126/scisignal.aad3895. *shared first author

Veröffentlichungen 2015

Glucokinase activation is beneficial or toxic to cultured rat pancreatic islets depending on the prevailing glucose concentration.
Roma LP, Duprez J, Jonas JC.
American Journal of Physiology-Endocrinology and Metabolism. 2015 Oct 1; 309(7):E632-9.

Insulin replacement restores the vesicular secretory apparatus in the diabetic rat lacrimal gland.
Dias AC, Batista TM, Roma LP, Módulo CM, Malki LT, Dias LC, Alves M, Reinach PS, Carneiro EM, Rocha EM.
Arquivos Brasileiros de Oftalmologia. 2015.

Omega-3 supplementation improves pancreatic islet redox status: in vivo and in vitro studies
Lucena CF, Roma LP, Simões D, Graciano MF, Veras K, Curi R, Carpinelli AR.
Pancreas. 2015 Mar; 44(2):287-95. doi: 10.1097/mpa.0000000000000249.

Veröffentlichungen 2014

Acute nutrient regulation of mitochondrial glutathione redox state in rat pancreatic β-cells.
Takahashi HK, Santos LRB, Roma LP, Duprez J, Jonas JC.
Biochem J. 2014 Jun 15; 460(3):411-23. doi: 10.1042/BJ20131361.

Progesterone induces apoptosis of insulin-secreting cells: insights into the molecular mechanism.
Nunes VA, Portioli-Sanches EP, Rosim MP, Araujo MS, Praxedes-Garcia P , Valle MMR, Roma LP, Gurgul-Convey E, Lenzen S, Azevedo-Martins AK.
J Endocrinol. 2014 Apr 22; 221(2):273-84. doi: 10.1530/JOE-13-0202.

Veröffentlichungen 2013

Impaired muscarinic type 3 (M3) receptor/PKC and PKA pathways in islets from MSG-obese rats.
Ribeiro RA, Balbo SL, Roma LP, Camargo RL, Barella LF, Vanzela EC, de Freitas Mathias PC, Carneiro EM, Boschero AC, Bonfleur ML.
Mol Biol Rep. 2013 Jul; 40(7):4521-8.

Dual effect of advanced glycation end products (AGEs) in pancreatic islet apoptosis.
Costal F, Oliveira E, Raposo A, Machado-Lima A, Peixoto E, Roma L, Santos L, Lopes Faria J, Carpinelli AR, Giannella-Neto D, Passarelli M, Correa-Giannella ML.
Diabetes Metab Res Rev. 2013 Jan 12.

Veröffentlichungen 2012

Protective antioxidant and antiapoptotic effects of ZnCl2 in rat pancreatic islets cultured in low and high glucose concentrations.
Duprez J, Roma LP, Close AF, Jonas JC.
PloS One. 2012; 7(10).

Mitochondrial oxidative stress differently contributes to rat pancreatic islet cell apoptosis and insulin secretory defect after prolonged culture in low glucose.
Roma LP, Pascal SM, Duprez J, Jonas JC.
Diabetologia. 2012 Aug; 55(8):2226-37.

Dynamic measurements of mitochondrial hydrogen peroxide concentration and glutathione redox state in rat pancreatic β-cells using ratiometric fluorescent proteins: confounding effects of pH with Hyper but not roGFP1.
Roma LP, Duprez J, Takahashi HK, Gilon P, Wiederkehr A, Jonas JC.
Biochem J. 2012 Feb 1; 441(3):971-8.

Pancreatic islets from dexamethasone-treated rats show alterations in global gene expression and mitochondrial pathways.
Roma LP, K. L. A. Souza, E. M. Carneiro, A. C. Boschero, J. R. Bosqueiro.
Gen. Physiol. Biophys. 2012; 31:65–76

Age-dependent changes in rat lacrimal gland anti-oxidant and vesicular related protein expression profiles.
Batista TM, Tomiyoshi LM, Dias AC, Roma LP, Módulo CM, Malki LT, Filho EB, Deminice R, Jordão AA Jr, Cunha DA, Rocha EM.
Mol Vis. 2012; 18:194-202. Epub 2012 Jan 25.

Veröffentlichungen 2011

N-acetylcysteine protects pancreatic islet against glucocorticoid toxicity.
Roma LP, Carneiro, Everardo M, Boschero, AC, Souza KLA.
Redox Rep. 2011; 16(4):173-80.

Mechanisms of control of the free Ca2+ concentration in the endoplasmic reticulum of mouse pancreatic beta-cells: interplay with cell metabolism and [Ca2+]c, and role of SERCA2b and SERCA3.
Ravier MA, Daro D, Roma LP, Jonas JC, Cheng-Xue R, Schuit FC, Gilon P.
Diabetes. 2011 Oct; 60(10):2533-45.

Veröffentlichungen 2009

Protection of insulin-producing cells against toxicity of dexamethasone by catalase overexpression.
Roma LP, Bosqueiro JR, Cunha DA, Carneiro EM, Gurgul-Convey E, Lenzen S, Boschero AC, Souza KL.
Free Radical Biology & Medicine. 2009 Nov 15; 47(10):1386-93.

Veröffentlichungen 2007

Prolactin modulates the association and phosphorylation of SNARE and kinesin/MAP-2 proteins in neonatal pancreatic rat islets.
Cunha DA, LP, Boschero AC.
Mol Cell Endocrinol. 2007 Jul 15; 273(1-2):32-41.

Dexamethasone-induced insulin resistance is associated with increased connexin 36 mRNA and protein expression in pancreatic rat islets.
Rafacho A, Roma LP, Taboga SR, Boschero AC, Bosqueiro JR.
Can Journal of Physiology and Pharmacology. 2007 May; 85(5):536-45.