Cellular Immunology
Publications
Publications
Selected publications
1. Tu S-M, Lin C-H, Liu Y, Schirra C, Yang C-A, Hohneck J, Jung M, Clemenz A, Rother S, Aljohmani A, Yildiz D, Schwarz Y, Krause E, Schulz-Schaeffer WJ, Flockerzi V, Yao C-K, Chang H-F*. Flower isoforms mediate fitness selection of astrocytes through extracellular vesicles. EMBO Reports. 2026. Accepted.
2. Li X, Schirra C, Wirkner M-L, Tu S-M, Lin C-H, Hohmann M, Alawar N, Chouaib A, Becherer U, Pattu V, Rettig J, Krause E*, Chang H-F*. Lytic IFNγ is stored in granzyme B-containing cytotoxic granules and co-secreted by effector CD8⁺ T cells. Cell. Mol. Immunol. 2026. DOI: 10.1038/s41423-026-01391-1
3. Chouaib AA, Chang H-F, Khamis OM, Alawar N, Echeverry S, Demeersseman L, Elizarova S, Daniel JA, Tian Q, Lipp P, Fornasiero EF, Valitutti S, Barg S, Pape C, Shaib AH, Becherer U. Highly adaptable deep-learning platform for automated detection and analysis of vesicle exocytosis. Nat Commun. 2025. 16(1):6450.
4. Ravichandran K, Schirra C, Urbansky K, Tu SM, Alawar N, Mannebach S, Krause E, Stevens D, Lancaster CRD, Flockerzi V, Rettig J, Chang H-F*, Becherer U*. Required Minimal Protein Domain of Flower for Synaptobrevin2 Endocytosis in Cytotoxic T Cells. Cell Mol Life Sci. 2024. 82(1):8. *co-corresponding author.
5. Lin CH, Scheller A, Liu Y, Krause E, Chang H-F*. Study of Effector CD8+ T Cell Interactions with Cortical Neurons in Response to Inflammation in Mouse Brain Slices and Neuronal Cultures. Int J Mol Sci. 2023. 24(4):3166.
6. Chang H-F*, Schirra C, Ninov M, Hahn U, Ravichandran K, Krause E, Becherer U, Bálint Š, Harkiolaki M, Urlaub H, Valitutti S, Baldari CT, Dustin ML, Jahn R, and Rettig J*. Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes. Nat. Commun. 2022. 13(1):1029. *co-corresponding author.
7. Chitirala P†, Chang H-F†, Martzloff P, Harenberg C, Ravichandran K, Abdulreda MH, Berggren PO, Krause E, Schirra C, Leinders-Zufall T, Benseler F, Brose N, Rettig J. Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse. eLife. 2020. 9: e58065. †equal contribution
8. Lodygin D, Hermann M, Schweingruber N, Flügel-Koch C, Watanabe T, Schlosser C, Merlini A, Körner H, Chang H-F, Fischer HJ, Reichardt HM, Zagrebelsky M, Mollenhauer B, Frahm J, Stadelmann C, Kügler S, Fitzner D, Haberl M, Odoardi F, Flügel A. β-Synuclein reactive T cells induce autoimmune CNS grey matter degeneration. Nature 2019. 566, 503-508.
9. Chang H-F, Mannebach S, Beck A, Ravichandran K, Krause E, Frohnweiler K, Fecher-Trost C, Schirra C, Pattu V, Flockerzi V, Rettig J. Cytotoxic granule endocytosis depends on the Flower protein. J. Cell Biol. 2018. 217, 667-683.
View all publications on ORCID: https://orcid.org/0000-0002-7691-4090