Molecular Physiology

Frank Kirchhoff | Molecular Physiology

 

2025

Fang LP, Zhao Y, Bai X. Oligodendrocyte precursor cellneuronal lysosomal pathway: A novel therapeutic target for neurodegenerative diseases. Neural Regen Res. 2025 Sep 29. doi: 10.4103/NRR.NRR-D-25-00625

Chen H, Sun YY, Li QF, Du YT, Hu NN, Sui AR, Luo XQ, Huang X, Zhu C, Yang G, Yao LL, Tang Y, Hu H, Liu CF, Tao J, Feng L, Kirchhoff F, Huang W, Li S, Ma QH. Impaired macroautophagy in oligodendrocyte precursor cells suppresses neuronal plasticity via a senescence-associated signaling. Sci Adv. 2025 Sep 26;11(39):eadq7665. doi: 10.1126/sciadv.adq7665

Xu J, Mao X, Liu Z, Jiang N, Wong XE, Liu D, Wang Y, Zhan H, Liu S, Yu J, Yuan R, Bai Q, Bai X, Huang W, Xie R, Krenn V, Kirchhoff F, Wang H, Guo Z, Bian S. CETN3 deficiency induces microcephaly by disrupting neural stem/progenitor cell fate through impaired centrosome assembly and RNA splicing. EMBO Mol Med. 2025 Sep 8. doi: 10.1038/s44321-025-00302-7

Bortolanza M, Gobbo D, Fang L, Scheller A, Bai X, Kirchhoff F. Sex-Specific Properties of Astrocytes: From Development to Evolutionary Insights. Neurochem Res. 2025 Aug 13;50(4):267. doi: 10.1007/s11064-025-04512-w

Preishuber-Pflügl J, Brunner SM, Huang W, Koller A, Reitsamer HA, Trost A. Targeting pericytes in the retina: characterization of the inducible NG2-CreERT2 knock-in mouse model. Exp Eye Res. 2025 Sep;258:110519. doi: 10.1016/j.exer.2025.110519

Song H, Li Y, Liu J, Bai X, Jiang L, Li T. Astrocytic connexin 43-hemichannels aggravate seizures by modulating blood-brain barrier permeability in temporal lobe epilepsy mice. Pediatr Discov. 2024 Aug 2;2(3):e2500. doi: 10.1002/pdi3.2500

Rodrigues da Silva N, Gobbo D, Gomes FV, Scheller A, Kirchhoff F, Del Bel E, Silveira Guimarães F. Cannabidiol reverses microglia activation and deficits of parvalbumin interneurons and their perineuronal nets in a MK-801-induced mouse model of schizophrenia. Brain Res. 2025 Sep 15;1863:149772. doi:10.1016/j.brainres.2025.149772

Guo Q, Seth R, Huang W. Adenosine: A key player in neuroinflammation. Neural Regen Res. 2026 Apr 1;21(4):1556-1557. doi: 10.4103/NRR.NRR-D-24-01486

Gobbo D, Kirchhoff F. Animal-based approaches to understanding neuroglia physiology in vitro and in vivo. Handb Clin Neurol. 2025;209:229-263. doi:10.1016/B978-0-443-19104-6.00012-7

Fang LP, Lin CH, Medlej Y, Zhao R, Chang HF, Guo Q, Wu Z, Su Y, Zhao N,Gobbo D, Wyatt A, Wahl V, Fiore F, Tu SM, Boehm U, Huang W, Bian S, Agarwal A, Lauterbach MA, Yi C, Niu J, Scheller A, Kirchhoff F, Bai X. Oligodendrocyte precursor cells facilitate neuronal lysosome release. Nat Commun. 2025 Jan 30;16(1):1175. doi: 10.1038/s41467-025-56484-8

 

2024

 

Godeanu S, Mușat MI, Scheller A, Osiac E, Cătălin B. Minimal differences observed when comparing the morphological profiling of microglia obtained by confocal laser scanning and optical sectioning microscopy. Front Neuroanat. 2025 Jan 3;18:1507140. doi: 10.3389/fnana.2024.1507140

Bai Y, Zhou Z, Han B, Xiang X, Huang W, Yao H. Revisiting astrocytic calcium signaling in the brain. Fundam Res. 2024 Feb 8;4(6):1365-1374. doi: 10.1016/j.fmre.2023.11.021

Gobbo D, Rieder P, Fang LP, Buttigieg E, Schablowski M, Damo E, Bosche N, Dallorto E, May P, Bai X, Kirchhoff F, Scheller A. Genetic Downregulation of GABA_B Receptors from Oligodendrocyte Precursor Cells Protects Against Demyelination in the Mouse Spinal Cord. Cells. 2024 Dec 5;13(23):2014. doi: 10.3390/cells13232014

Zhou Z, Bai Y, Gu X, Ren H, Xi W, Wang Y, Bian L, Liu X, Shen L, Xiang X, Huang W, Luo Z, Han B, Yao H. Membrane Associated RNA-Containing Vesicles Regulate Cortical Astrocytic Microdomain Calcium Transients in Awake Ischemic Stroke Mice. Adv Sci (Weinh). 2024 Dec;11(46):e2404391. doi: 10.1002/advs.202404391

Chen H, Yang G, Xu DE, Du YT, Zhu C, Hu H, Luo L, Feng L, Huang W, Sun YY, Ma QH. Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age-dependent Manner. Neurosci Bull. 2025 Mar;41(3):374-390. doi: 10.1007/s12264-024-01292-1

Bai X. Cytokine relay from the peripheral to the central: Secrets behind fever. Acta Physiol (Oxf). 2024 Dec;240(12):e14225. doi: 10.1111/apha.14225

Guo Q, Gobbo D, Zhao N, Zhang H, Awuku NO, Liu Q, Fang LP, Gampfer TM, Meyer MR, Zhao R, Bai X, Bian S, Scheller A, Kirchhoff F, Huang W. Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice. Nat Commun. 2024 Jul 27;15(1):6340. doi: 10.1038/s41467-024-50466-y

Haroon A, Seerapu H, Fang LP, Weß JH, Bai X. Unlocking the Potential: immune functions of oligodendrocyte precursor cells. Front Immunol. 2024 Jul 9;15:1425706. doi: 10.3389/fimmu.2024.1425706

 

2023

da Silva NS, Lombardi J, Kirchhoff F, Ferreira RS Jr, Barraviera B, de Oliveira ALR, Cartarozzi LP. Effects of local and systemic treatment with human natural killer-1 mimetic peptide (HNK-1) after ventral root avulsion and reimplantation in mice. J Venom Anim Toxins Incl Trop Dis. 2024 May 20;30:e20230065. doi: 10.1590/1678-9199-JVATITD-2023-0065

Kirchhoff F, Tang W. Analysis of Functional NMDA Receptors in Astrocytes. Methods Mol Biol. 2024;2799:201-223. doi: 10.1007/978-1-0716-3830-9_11

Koupourtidou C, Schwarz V, Aliee H, Frerich S, Fischer-Sternjak J, Bocchi R, Simon-Ebert T, Bai X, Sirko S, Kirchhoff F, Dichgans M, Götz M, Theis FJ, Ninkovic J. Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex. Nat Commun. 2024 Apr 3;15(1):2866. doi: 10.1038/s41467-024-46625-w

González-Arias C, Sánchez-Ruiz A, Esparza J, Sánchez-Puelles C, Arancibia L, Ramírez-Franco J, Gobbo D, Kirchhoff F, Perea G. Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states. Mol Psychiatry. 2023 Sep;28(9):3856-3873. doi: 10.1038/s41380-023-02269-8

Stopper G, Caudal LC, Rieder P, Gobbo D, Stopper L, Felix L, Everaerts K, Bai X, Rose CR, Scheller A, Kirchhoff F. Novel algorithms for improved detection and analysis of fluorescent signal fluctuations. Pflugers Arch. 2023 Nov;475(11):1283-1300. doi: 10.1007/s00424-023-02855-3

Fang LP, Bai X. Implications of Olig2 silencing in oligodendrocyte precursor cells. Neural Regen Res. 2023 Dec;18(12):2649-2650. doi: 10.4103/1673-5374.373666

Werner L, Gliem M, Rychlik N, Pavic G, Reiche L, Kirchhoff F, Silva Oliveira Junior M, Gruchot J, Meuth SG, Küry P, Göttle P. A Novel Ex Vivo Model to Study Therapeutic Treatments for Myelin Repair following Ischemic Damage. Int J Mol Sci. 2023 Jun 30;24(13):10972. doi: 10.3390/ijms241310972

Xingi E, Koutsoudaki PN, Thanou I, Phan MS, Margariti M, Scheller A, Tinevez JY, Kirchhoff F, Thomaidou D. LPS-Induced Systemic Inflammation Affects the Dynamic Interactions of Astrocytes and Microglia with the Vasculature of the Mouse Brain Cortex. Cells. 2023 May 17;12(10):1418. doi: 10.3390/cells12101418

Fang LP, Bai X. Oligodendrocyte precursor cells: the multitaskers in the brain. Pflugers Arch. 2023 Sep;475(9):1035-1044. doi: 10.1007/s00424-023-02837-5

Bai X, Zhao N, Koupourtidou C, Fang LP, Schwarz V, Caudal LC, Zhao R, Hirrlinger J, Walz W, Bian S, Huang W, Ninkovic J, Kirchhoff F, Scheller A. In the mouse cortex, oligodendrocytes regain a plastic capacity, transforming into astrocytes after acute injury. Dev Cell. 2023 Jul 10;58(13):1153-1169.e5. doi: 10.1016/j.devcel.2023.04.016

Kaestner L, Champigneulle B, Stauffer É, Furian M, De Abreu J, John T, Nader E, Scheller A, Pichon A, Connes P, Robach P, Brugniaux JV, Borsch C, Rudloff S, Mairbäurl H, Verges S. Neocytolysis after return from high altitude (5100 m): Further evidence for absentia. Acta Physiol (Oxf). 2023 Jul;238(3):e14002. doi: 10.1111/apha.14002

Hassel LA, Fröb F, Küspert M, Hillgärtner S, Arnold P, Huang W, Kirchhoff F, Wegner M. Differential activity of transcription factor Sox9 in early and adult oligodendroglial progenitor cells. Glia. 2023 Aug;71(8):1890-1905. doi: 10.1002/glia.24373

Godeanu S, Clarke D, Stopper L, Deftu AF, Popa-Wagner A, Bălșeanu AT, Scheller A, Cătălin B. Microglial morphology in the somatosensory cortex across lifespan. A quantitative study. Dev Dyn. 2023 Aug;252(8):1113-1129. doi: 10.1002/dvdy.582

Lin CH, Scheller A, Liu Y, Krause E, Chang HF. Study of Effector CD8+ T Cell Interactions with Cortical Neurons in Response to Inflammation in Mouse Brain Slices and Neuronal Cultures. Int J Mol Sci. 2023 Feb 6;24(4):3166. doi: 10.3390/ijms24043166

Timmermann A, Tascio D, Jabs R, Boehlen A, Domingos C, Skubal M, Huang W, Kirchhoff F, Henneberger C, Bilkei-Gorzo A, Seifert G, Steinhäuser C. Dysfunction of NG2 glial cells affects neuronal plasticity and behavior. Glia. 2023 Jun;71(6):1481-1501. doi: 10.1002/glia.24352

Buttigieg E, Scheller A, El Waly B, Kirchhoff F, Debarbieux F. Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis. Neurotherapeutics. 2023 Jan;20(1):22-38. doi: 10.1007/s13311-022-01324-6

 

2022

Martínez-Mendoza ML, Rodríguez-Arzate CA, Gómez-González GB, Kirchhoff F, Martínez-Torres A. Analysis of a cell niche with proliferative potential at the roof of the aqueduct of Sylvius. Neurosci Res. 2023 Mar;188:28-38. doi: 10.1016/j.neures.2022.11.004

Meyer E, Rieder P, Gobbo D, Candido G, Scheller A, de Oliveira RMW, Kirchhoff F. Cannabidiol Exerts a Neuroprotective and Glia-Balancing Effect in the Subacute Phase of Stroke. Int J Mol Sci. 2022 Oct 25;23(21):12886. doi: 10.3390/ijms232112886

He H, Yang W, Su N, Zhang C, Dai J, Han F, Singhal M, Bai W, Zhu X, Zhu J, Liu Z, Xia W, Liu X, Zhang C, Jiang K, Huang W, Chen D, Wang Z, He X, Kirchhoff F, Li Z, Liu C, Huan J, Wang X, Wei W, Wang J, Augustin HG, Hu J. Activating NO-sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury. J Exp Med. 2023 Feb 6;220(2):e20211422. doi: 10.1084/jem.20211422

Fang LP, Liu Q, Meyer E, Welle A, Huang W, Scheller A, Kirchhoff F, Bai X. A subset of OPCs do not express Olig2 during development which can be increased in the adult by brain injuries and complex motor learning. Glia. 2023 Feb;71(2):415-430. doi: 10.1002/glia.24284

Struckmeier AK, Radermacher A, Fehrenz M, Alansary D, Wartenberg P, Wagner M, Scheller A, Hess J, Moratin J, Freudlsperger C, Hoffmann J, Thurner L, Roemer K, Freier K, Horn D. TREM2 Is Associated with Advanced Stages and Inferior Prognosis in Oral Squamous Cell Carcinoma. Cancers (Basel). 2022 Sep 24;14(19):4635. doi: 10.3390/cancers14194635

Meyer E, Scheller A. Pathology-induced NG2 proteoglycan expression in microglia. Neural Regen Res. 2023 Apr;18(4):801-802. doi: 10.4103/1673-5374.353488

Liu Q, Guo Q, Fang LP, Yao H, Scheller A, Kirchhoff F, Huang W. Specific detection and deletion of the sigma-1 receptor widely expressed in neurons and glial cells in vivo. J Neurochem. 2023 Mar;164(6):764-785. doi: 10.1111/jnc.15693

Struckmeier AK, Radermacher A, Fehrenz M, Bellin T, Alansary D, Wartenberg P, Boehm U, Wagner M, Scheller A, Hess J, Moratin J, Freudlsperger C, Hoffmann J, Thurner L, Roemer K, Freier K, Horn D. IDO1 is highly expressed in macrophages of patients in advanced tumour stages of oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2023 Jul;149(7):3623-3635. doi: 10.1007/s00432-022-04277-7

Laporte MH, Chi KI, Caudal LC, Zhao N, Schwarz Y, Rolland M, Martinez-Hernandez J, Martineau M, Chatellard C, Denarier E, Mercier V, Lemaître F, Blot B, Moutaux E, Cazorla M, Perrais D, Lanté F, Bruns D, Fraboulet S, Hemming FJ, Kirchhoff F, Sadoul R. Alix is required for activity-dependent bulk endocytosis at brain synapses. PLoS Biol. 2022 Jun 3;20(6):e3001659. doi: 10.1371/journal.pbio.3001659

Rieder P, Gobbo D, Stopper G, Welle A, Damo E, Kirchhoff F, Scheller A. Astrocytes and Microglia Exhibit Cell-Specific Ca²⁺ Signaling Dynamics in the Murine Spinal Cord. Front Mol Neurosci. 2022 Mar 30;15:840948. doi: 10.3389/fnmol.2022.840948

Fang LP, Zhao N, Caudal LC, Chang HF, Zhao R, Lin CH, Hainz N, Meier C, Bettler B, Huang W, Scheller A, Kirchhoff F, Bai X. Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior. Nat Commun. 2022 Mar 16;13(1):1394. doi: 10.1038/s41467-022-29020-1

Qin X, Wang J, Chen S, Liu G, Wu C, Lv Q, He X, Bai X, Huang W, Liao H. Astrocytic p75^NTR expression provoked by ischemic stroke exacerbates the blood-brain barrier disruption. Glia. 2022 May;70(5):892-912. doi: 10.1002/glia.24146

Hohmann U, Walsleben C, Ghadban C, Kirchhoff F, Dehghani F, Hohmann T. Interaction of Glia Cells with Glioblastoma and Melanoma Cells under the Influence of Phytocannabinoids. Cells. 2022 Jan 3;11(1):147. doi: 10.3390/cells11010147

Schweigmann M, Kirchhoff F, Koch KP. Comparative study of platinum electroplating to improve micro gold electrode arrays with LCP laminate. Biomed Tech (Berl). 2022 Jan 11;67(1):33-42. doi: 10.1515/bmt-2021-0020

Cartarozzi LP, Perez M, Fernandes GG, Chiarotto GB, Luzo ÂCM, Campos AC, Kirchhoff F, de Oliveira ALR. Neuroprotection and gliosis attenuation by intravenous application of human mesenchymal stem cells (hMSC) following ventral root crush in mice. Mol Cell Neurosci. 2022 Jan;118:103694. doi: 10.1016/j.mcn.2021.103694

Decker Y, Krämer J, Xin L, Müller A, Scheller A, Fassbender K, Proulx ST. Magnetic resonance imaging of cerebrospinal fluid outflow after low-rate lateral ventricle infusion in mice. JCI Insight. 2022 Feb 8;7(3):e150881. doi: 10.1172/jci.insight.150881

 

2021

 

Zhao N, Huang W, Cãtãlin B, Scheller A, Kirchhoff F. L-Type Ca²⁺ Channels of NG2 Glia Determine Proliferation and NMDA Receptor-Dependent Plasticity. Front Cell Dev Biol. 2021 Oct 21;9:759477. doi: 10.3389/fcell.2021.759477

Xie YY, Pan TT, Xu DE, Huang X, Tang Y, Huang W, Chen R, Lu L, Chi H, Ma QH. Clemastine Ameliorates Myelin Deficits via Preventing Senescence of Oligodendrocytes Precursor Cells in Alzheimer's Disease Model Mouse. Front Cell Dev Biol. 2021 Oct 21;9:733945. doi: 10.3389/fcell.2021.733945

Schweigmann M, Caudal LC, Stopper G, Scheller A, Koch KP, Kirchhoff F. Versatile Surface Electrodes for Combined Electrophysiology and Two-Photon Imaging of the Mouse Central Nervous System. Front Cell Neurosci. 2021 Aug 10;15:720675. doi: 10.3389/fncel.2021.720675

Müller FE, Cherkas V, Stopper G, Caudal LC, Stopper L, Kirchhoff F, Henneberger C, Ponimaskin EG, Zeug A. Elucidating regulators of astrocytic Ca²⁺ signaling via multi-threshold event detection (MTED). Glia. 2021 Dec;69(12):2798-2811. doi: 10.1002/glia.24070

Gobbo D, Scheller A, Kirchhoff F. From Physiology to Pathology of Cortico-Thalamo-Cortical Oscillations: Astroglia as a Target for Further Research. Front Neurol. 2021 Jun 9;12:661408. doi: 10.3389/fneur.2021.661408

Welle A, Kasakow CV, Jungmann AM, Gobbo D, Stopper L, Nordström K, Salhab A, Gasparoni G, Scheller A, Kirchhoff F, Walter J. Epigenetic control of region-specific transcriptional programs in mouse cerebellar and cortical astrocytes. Glia. 2021 Sep;69(9):2160-2177. doi: 10.1002/glia.24016

Hou J, Bi H, Ye Z, Huang W, Zou G, Zou X, Shi YS, Shen Y, Ma Q, Kirchhoff F, Hu Y, Chen G. Pen-2 Negatively Regulates the Differentiation of Oligodendrocyte Precursor Cells into Astrocytes in the Central Nervous System. J Neurosci. 2021 Jun 9;41(23):4976-4990. doi: 10.1523/JNEUROSCI.2455-19.2021

Li ZY, Chen LH, Zhao XY, Chen H, Sun YY, Lu MH, Wang ZT, Chen M, Lu L, Huang W, Chen R, Xu DE, Xu RX, Ma QH. Clemastine attenuates AD-like pathology in an AD model mouse via enhancing mTOR-mediated autophagy. Exp Neurol. 2021 Aug;342:113742. doi: 10.1016/j.expneurol.2021.113742

Bai X, Kirchhoff F, Scheller A. Oligodendroglial GABAergic Signaling: More Than Inhibition! Neurosci Bull. 2021 Jul;37(7):1039-1050. doi: 10.1007/s12264-021-00693-w

Kapitza C, Chunder R, Scheller A, Given KS, Macklin WB, Enders M, Kuerten S, Neuhuber WL, Wörl J. Murine Esophagus Expresses Glial-Derived Central Nervous System Antigens. Int J Mol Sci. 2021 Mar 22;22(6):3233. doi: 10.3390/ijms22063233

Ulbricht C, Leben R, Rakhymzhan A, Kirchhoff F, Nitschke L, Radbruch H, Niesner RA, Hauser AE. Intravital quantification reveals dynamic calcium concentration changes across B cell differentiation stages. Elife. 2021 Mar 22;10:e56020. doi: 10.7554/eLife.56020

Romeo R, Boden-El Mourabit D, Scheller A, Mark MD, Faissner A. Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) as a Novel Regulator of Early Astroglial Differentiation. Front Cell Neurosci. 2021 Feb 18;15:642521. doi: 10.3389/fncel.2021.642521

Ferreira FR, Cupido A, Cătălin B, Silva WA Jr, Kirchhoff F, Del-Bel EA, Guimarães FS. Astrocyte Intracellular Ca²⁺ and TrkB Signaling in the Hippocampus Could Be Involved in the Beneficial Behavioral Effects of Antidepressant Treatment. Neurotox Res. 2021 Jun;39(3):860-871. doi: 10.1007/s12640-021-00334-0

Romeo R, Glotzbach K, Scheller A, Faissner A. Deletion of LRP1 From Astrocytes Modifies Neuronal Network Activity in an in vitro Model of the Tripartite Synapse. Front Cell Neurosci. 2021 Jan 14;14:567253. doi: 10.3389/fncel.2020.567253

 

2020

 

Caudal LC, Gobbo D, Scheller A, Kirchhoff F. The Paradox of Astroglial Ca ²⁺ Signals at the Interface of Excitation and Inhibition. Front Cell Neurosci. 2020 Nov 26;14:609947. doi: 10.3389/fncel.2020.609947

Müller FE, Schade SK, Cherkas V, Stopper L, Breithausen B, Minge D, Varbanov H, Wahl-Schott C, Antoniuk S, Domingos C, Compan V, Kirchhoff F, Henneberger C, Ponimaskin E, Zeug A. Serotonin receptor 4 regulates hippocampal astrocyte morphology and function. Glia. 2021 Apr;69(4):872-889. doi: 10.1002/glia.23933

Huang W, Bai X, Meyer E, Scheller A. Acute brain injuries trigger microglia as an additional source of the proteoglycan NG2. Acta Neuropathol Commun. 2020 Aug 26;8(1):146. doi: 10.1186/s40478-020-01016-2

Guo Q, Scheller A, Huang W. Progenies of NG2 glia: what do we learn from transgenic mouse models ? Neural Regen Res. 2021 Jan;16(1):43-48. doi: 10.4103/1673-5374.286950

Chen A, Guo Z, Fang L, Bian S. Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders. Front Cell Neurosci. 2020 May 15;14:133. doi: 10.3389/fncel.2020.00133

Barro-Soria R, Caicedo A, Jägle H, Merkel L, Zhao N, Knop G, Gierke K, Dannullis A, Castrop H, Brandstätter JH, Kirchhoff F, Feigenspan A, Strauß O. Angiotensin-Receptor-Associated Protein Modulates Ca²⁺ Signals in Photoreceptor and Mossy Fiber cells. Sci Rep. 2019 Dec 23;9(1):19622. doi: 10.1038/s41598-019-55380-8

Zhu JW, Zou MM, Li YF, Chen WJ, Liu JC, Chen H, Fang LP, Zhang Y, Wang ZT, Chen JB, Huang W, Li S, Jia WQ, Wang QQ, Zhen XC, Liu CF, Li S, Xiao ZC, Xu GQ, Schwamborn JC, Schachner M, Ma QH, Xu RX. Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling. Cereb Cortex. 2020 May 14;30(5):3240-3258. doi: 10.1093/cercor/bhz306

 

 

2019

Schäfer I, Kaisler J, Scheller A, Kirchhoff F, Haghikia A, Faissner A. Conditional Deletion of LRP1 Leads to Progressive Loss of Recombined NG2-Expressing Oligodendrocyte Precursor Cells in a Novel Mouse Model. Cells.  2019 Nov 30;8(12):1550. doi: 10.3390/cells8121550

Beiersdorfer A, Wolburg H, Grawe J, Scheller A, Kirchhoff F, Lohr C (2019) Sublamina-specific organization of the blood brain barrier in the mouse olfactory nerve layer. Glia. 2020 Mar;68(3):631-645. doi: 10.1002/glia.23744. Epub 2019 Nov 7. PubMed PMID: 31696993.

 Barro-Soria R, Caicedo A, Jägle H, Merkel L, Zhao N, Knop G, Gierke K, Dannullis A, Castrop H, Brandstätter JH, Kirchhoff F, Feigenspan A, Strauß O. (2019) Angiotensin-Receptor-Associated Protein Modulates Ca(2+) Signals in Photoreceptor and Mossy Fiber cells. Sci Rep. 2019 Dec 23;9(1):19622. doi: 10.1038/s41598-019-55380-8. PubMed PMID: 31873081; PubMed Central PMCID: PMC6928155

Schäfer I, Kaisler J, Scheller A, Kirchhoff F, Haghikia A, Faissner A (2019) Conditional Deletion of LRP1 Leads to Progressive Loss of Recombined NG2-Expressing Oligodendrocyte Precursor Cells in a Novel Mouse Model. Cells 30;8(12). pii: E1550. doi: 10.3390/cells8121550. PubMed PMID: 31801252; PubMed Central PMCID: PMC6953036.

Zhu JW, Zou MM, Li YF, Chen WJ, Liu JC, Chen H, Fang LP, Zhang Y, Wang ZT, Chen JB, Huang W, Li S, Jia WQ, Wang QQ, Zhen XC, Liu CF, Li S, Xiao ZC, Xu GQ, Schwamborn JC, Schachner M, Ma QH, Xu RX (2019) Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling. Cereb Cortex. 2019 Dec 11. pii: bhz306. doi: 10.1093/cercor/bhz306. PMID: 31828304

Nalbach L, Schmitt BM, Becker V, Scheller A, Laschke MW, Menger MD, Ampofo E. (2019) Nerve/glial antigen 2 is crucially involved in the revascularization of freely transplanted pancreatic islets. Cell Tissue Res 378(2):195-205. doi: 10.1007/s00441-019-03048-0. Epub 2019 May 27. PubMed PMID: 31131431

Cartarozzi LP, Perez M, Kirchhoff F, Oliveira ALR (2019) Role of MHC-I Expression on Spinal Motoneuron Survival and Glial Reactions Following Ventral Root Crush in Mice. Cells. 21;8(5). pii: E483. doi: 10.3390/cells8050483. PubMed PMID: 31117227; PubMed Central PMCID: PMC6563038.

Grundmann D, Loris E, Maas-Omlor S, Huang W, Scheller A, Kirchhoff F, Schäfer KH (2019) Enteric Glia: S100, GFAP, and Beyond. Anat Rec (Hoboken) 302(8):1333-1344. doi: 10.1002/ar.24128. Epub 2019 Apr 29. PubMed PMID: 30951262.

Beiersdorfer A, Scheller A, Kirchhoff F, Lohr C (2019) Panglial gap junctions between astrocytes and olfactory ensheathing cells mediate transmission of Ca(2+) transients and neurovascular coupling. Glia 67(7):1385-1400. doi: 10.1002/glia.23613. Epub 2019 Mar 18. PubMed PMID: 30883940.

Huang W, Guo Q, Bai X, Scheller A, Kirchhoff F (2019) Early embryonic NG2 glia are exclusively gliogenic and do not generate neurons in the brain. Glia 67(6):1094-1103. doi: 10.1002/glia.23590. Epub 2019 Feb 6. PubMed PMID: 30724411.

 

2018

Petrelli F, Dallérac G, Pucci L, Calì C, Zehnder T, Sultan S, Lecca S, Chicca A, Ivanov A, Asensio CS, Gundersen V, Toni N, Knott GW, Magara F, Gertsch J, Kirchhoff F, Déglon N, Giros B, Edwards RH, Mothet JP, Bezzi P. (2018) Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments. Mol Psychiatry. Aug 20. doi: 10.1038/s41380-018-0226-y. [Epub ahead of print] PMID: 30127471

Katz E, Stoler O, Scheller A, Khrapunsky Y, Goebbels S, Kirchhoff F, Gutnick MJ, Wolf F, Fleidervish IA (2018) Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons. Proc Natl Acad Sci U S A. 115: E7184-E7192. doi: 10.1073/pnas.1720493115. Epub 2018 Jul 10. PMID: 29991598

Stopper L, Bălşeanu TA, Cătălin B, Rogoveanu OC, Mogoantă L, Scheller A (2018) Microglia morphology in the physiological and diseased brain - from fixed tissue to in vivo conditions. Rom J Morphol Embryol. 2018;59(1):7-12. PMID: 29940606

Huang W, Bai X, Stopper L, Cătălin B, Cartarozzi LP, Scheller A, Kirchhoff F (2018) During Development NG2 Glial Cells of the Spinal Cord are Restricted to the Oligodendrocyte Lineage, but Generate Astrocytes upon Acute Injury. Neuroscience. 18;385:154-165. doi: 10.1016/j.neuroscience.2018.06.015. PMID: 29913244

Barros LF, Bolaños JP, Bonvento G, Bouzier-Sore AK, Brown A, Hirrlinger J, Kasparov S, Kirchhoff F, Murphy AN, Pellerin L, Robinson MB, Weber B (2018) Current technical approaches to brain energy metabolism. Glia. 2018 Jun;66(6):1138-1159. doi: 10.1002/glia.23248. Epub 2017 Nov 7. Review. PMID: 29110344

Schmitt BM, Laschke MW, Rössler OG, Huang W, Scheller A, Menger MD, Ampofo E (2018) Nerve/glial antigen (NG) 2 is a crucial regulator of intercellular adhesion molecule (ICAM)-1 expression. Biochim Biophys Acta. 2018 Jan;1865(1):57-66. doi: 10.1016/j.bbamcr.2017.09.019. Epub 2017 Sep 28. PMID: 28964848 [PubMed - indexed for MEDLINE]

Jahn HM, Kasakow CV, Helfer A, Michely J, Verkhratsky A, Maurer HH, Scheller A and Kirchhoff F (2018) Refined protocols of tamoxifen injection for inducible DNA recombination in mouse astroglia. Scientific Reports 8, 5913. doi: 10.1038/s41598-018-24085-9. PMID: 29651133

Cartarozzi LP, Rieder P, Bai X, Scheller A, Oliveira ALR, Kirchhoff F (2018) In vivo two-photon imaging of motoneurons and adjacent glia in the ventral spinal cord. J Neurosci Methods. 299:8-15. doi: 10.1016/j.jneumeth.2018.01.005. PMID: 29408351

 

2017

Wu ZQ, Li D, Huang Y, Chen XP, Huang W, Liu CF, Zhao HQ, Xu RX, Cheng M, Schachner M, Ma QH (2017) Caspr Controls the Temporal Specification of Neural Progenitor Cells through Notch Signaling in the Developing Mouse Cerebral Cortex. Cereb Cortex 27 1369-1385. PMID: 26740489

Hofmann K, Rodriguez-Rodriguez R, Gaebler A, Casals N, Scheller A, Kuerschner L (2017) Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids. Sci Rep-UK 7 10779. PMID: 28883484

Hofmann K, Lamberz C, Piotrowitz K, Offermann N, But D, Scheller A, Al-Amoudi A, Kuerschner L (2017) Tanycytes and a differential fatty acid metabolism in the hypothalamus. Glia 65 231-249. PMID: 27726181

Cătălin B, Stopper L, Bălşeanu TA, Scheller A (2017) The in situ morphology of microglia is highly sensitive to the mode of tissue fixation. J Chem Neuroanat 86 59-66. PMID: 28866082

Schwarz Y, Zhao N, Kirchhoff F, Bruns D (2017) Astrocytes control synaptic strength by two distinct v-SNARE-dependent release pathways. Nature neuroscience 20 (11):1529-1539. doi:10.1038/nn.4647. PMID: 28945220

Kirchhoff F (2017) Analysis of Functional NMDA Receptors in Astrocytes. Methods in molecular biology 1677:241-251. doi:10.1007/978-1-4939-7321-7_13. PMID: 28986877

Scheller A, Bai X, Kirchhoff F (2017) The Role of the Oligodendrocyte Lineage in Acute Brain Trauma. Neurochemical research 42 (9):2479-2489. doi:10.1007/s11064-017-2343-4. PMID: 28702713

Belkacemi T, Niermann A, Hofmann L, Wissenbach U, Birnbaumer L, Leidinger P, Backes C, Meese E, Keller A, Bai X, Scheller A, Kirchhoff F, Philipp SE, Weissgerber P, Flockerzi V, Beck A (2017) TRPC1- and TRPC3-dependent Ca(2+) signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo. Glia 65 (9):1535-1549. doi:10.1002/glia.23180. PMID: 28636132

Rollmann MF, Herath SC, Kirchhoff F, Braun BJ, Holstein JH, Pohlemann T, Menger MD, Histing T )2017) Pelvic ring fractures in the elderly now and then – a pelvic registry study. Arch Gerontol Geriatr 71:83-88. doi:                10.1016/j.archger.2017.03.007. Epub 2017 Mar 19. PubMed PMID: 28384504.

Berl S, Karram K, Scheller A, Jungblut M, Kirchhoff F, Waisman A (2017) Enrichment and isolation of neurons from adult mouse brain for ex vivo analysis. Journal of neuroscience methods 283:15-22. doi:10.1016/j.jneumeth.2017.03.015. PMID: 28336359

 

2016

Schneider S, Gruart A, Grade S, Zhang Y, Kröger S, Kirchhoff F, Eichele G, Delgado García JM, Dimou L. Decrease in newly generated oligodendrocytes leads to motor dysfunctions and changed myelin structures that can be rescued by transplanted cells. Glia. 2016 Sep 12. doi: 10.1002/glia.23055. [Epub ahead of print] PMID: 27615452

Grundmann D, Markwart F, Scheller A, Kirchhoff F, Schäfer KH (2016) Phenotype and distribution pattern of nestin-GFP-expressing cells in murine myenteric plexus. Cell Tissue Res. 2016 Aug 13. [Epub ahead of print] PMID: 27519533

Schweigmann M, Kirchhoff F, Koch KP (2016) Modeling and Simulations in Time Domain of a Stimulation Set-up for Cortical Applications. Eur J Transl Myol. 2016 Jun 13;26(2):6017. doi: 10.4081/ejtm.2016.6017. eCollection 2016 Jun 13. PMID: 27478564

Scheller A, Kirchhoff F (2016) Endocannabinoids and Heterogeneity of Glial Cells in Brain Function. Front Integr Neurosci. 2016 Jul 5;10:24. doi: 10.3389/fnint.2016.00024. eCollection 2016. No abstract available. PMID: 27458351

Saab AS, Tzvetavona ID, Trevisiol A, Baltan S, Dibaj P, Kusch K, Möbius W, Goetze B, Jahn HM, Huang W, Steffens H, Schomburg ED, Pérez-Samartín A, Pérez-Cerdá F, Bakhtiari D, Matute C, Löwel S, Griesinger C, Hirrlinger J, Kirchhoff F, Nave KA (2016) Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism. Neuron. 2016 Jul 6;91(1):119-32. doi: 10.1016/j.neuron.2016.05.016. Epub 2016 Jun 9. PMID: 27292539

Rudolph R, Jahn HM, Courjaret R, Messemer N, Kirchhoff F, Deitmer JW (2016) The inhibitory input to mouse cerebellar Purkinje cells is reciprocally modulated by Bergmann glial P2Y1 and AMPA receptor signaling. Glia. 2016 Jul;64(7):1265-80. doi: 10.1002/glia.22999. Epub 2016 May 4. PMID: 27144942

Resende FF, Bai X, Del Bel EA, Kirchhoff F, Scheller A, Titze-de-Almeida R (2016) Evaluation of TgH(CX3CR1-EGFP) mice implanted with mCherry-GL261 cells as an in vivo model for morphometrical analysis of glioma-microglia interaction. BMC Cancer. 2016 Feb 8;16:72. doi: 10.1186/s12885-016-2118-3. PMID: 26856327

 

2015

Schnell C, Negm M, Driehaus J, Scheller A, Hülsmann S (2015) Norepinephrine-induced calcium signaling in astrocytes in the respiratory network of the ventrolateral medulla. Respir Physiol Neurobiol. pii: S1569-9048(15)30062-8. doi: 10.1016/j.resp.2015.10.008. [Epub ahead of print] PMID: 26514085

Tristão FS, Lazzarini M, Martin S, Amar M, Stühmer W, Kirchhoff F, Gomes LA, Lanfumey L, Prediger RD, Sepulveda JE, Del-Bel EA, Raisman-Vozari R. (2015) CX3CR1 Disruption Differentially Influences Dopaminergic Neuron Degeneration in Parkinsonian Mice Depending on the Neurotoxin and Route of Administration. Neurotox Res. Sep 24. [Epub ahead of print] PMID: 26403659

Jahn HM, Scheller A, Kirchhoff F. (2015) Genetic control of astrocyte function in neural circuits. Front Cell Neurosci 9:310. doi: 10.3389/fncel.2015.00310. PMID: 26347607

 

2014

Scheller A, Vivien D, Kirchhoff F, Orset C, Sandu RE, Popa-Wagner A. (2014) Imaging neuroinflammation after brain injuries by ultrasensitive MRI and two-photon laser-scanning microscopy. Rom J Morphol Embryol 55(3):735-43. PMID: 25329099

Cupido A, Cătălin B, Steffens H, Kirchhoff F (2014) Surgical procedures to study microglial motility in the brain and in the spinal cord by in vivo two-photon laser-scanning microcopy. In: Laser Scanning Microscopy and Quantitative Image Analysis of Neuronal Tissue. Springer Protocols – Neuromethods. Humana Press.

Huang W, Zhao N, Bai X, Karram K, Trotter J, Goebbels S, Scheller A, Kirchhoff F (2014) Novel NG2-CreERT2 knock-in mice demonstrate heterogeneous differentiation potential of NG2 glia during devel-opment. Glia. Doi: 10.1002/glia.22648. [Epub ahead of print] PMID: 24578301

 

2013

Cătălin B, Cupido A, Iancău M, Albu CV, Kirchhoff F (2013) Microglia: first responders in the central nervous system. Rom J Morphol Embryol. 2013;54(3):467-72. PMID: 24068392

Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, Kirchhoff F, Möbius W, Goebbels S, Nave KA, Schneider A, Simons M, Klugmann M, Trotter J, Krämer-Albers EM (2013) Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol 11:e1001604. doi: 10.1371/journal.pbio.1001604. PMID: 23874151

Bai X, Saab AS, Huang W, Hoberg IK, Kirchhoff F, Scheller A (2013) Genetic Background Affects Human Glial Fibrillary Acidic Protein Promoter Activity. PLoS ONE. 10.1371/journal.pone.0066873. PMID: 23826164

Semar S, Klotz M, Letiembre M, Van Ginneken C, Braun A, Jost V, Bischof M, Lammers WJ, Liu Y, Fassbender K, Wyss-Coray T, Kirchhoff F, Schäfer KH. (2013) Changes of the Enteric Nervous System in Amyloid-β Protein Precursor Transgenic Mice Correlate with Disease Progression. J Alzheimers Dis. 36:7-20. doi: 10.3233/JAD-120511. PMID: 23531500

Kettenmann H, Kirchhoff F, Verkhratsky A (2013) Microglia: new roles for the synaptic stripper. Neuron 9:10-8. PMID: 23312512

Puschmann TB, Zandén C, De Pablo Y, Kirchhoff F, Pekna M, Liu J, Pekny M (2013) Bioactive 3D cell culture system minimizes cellular stress and maintains the in vivo-like morphological complexity of astroglial cells. Glia 61:432-40. PMID: 23292921

 

2012

Kirchhoff F (2012) Role of Microglia in the normal brain. In: Neuroglia. 3rd ed. Oxford University Press, New York. Eds. Kettenmann H and Ransom BR, pp 605-613

Steffens H, Nadrigny F, Kirchhoff F. (2012) In vivo two-photon imaging of neurons and glia in the mouse spinal cord. Cold Spring Harb Protoc. 2012 Dec 1 (12). doi:pii: pdb.prot072264. 10.1101/pdb.prot072264. PMID: 23209139

Steffens H, Nadrigny F, Kirchhoff F. (2012) Preparation of the mouse spinal column for repetitive imaging using two-photon laser-scanning microscopy. Cold Spring Harb Protoc. 2012 Dec 1 (12). doi:pii: pdb.prot072256. 10.1101/pdb.prot072256. PMID: 23209138

Steffens H, Nadrigny F, Kirchhoff F. (2012) Preparation of the mouse spinal column for single imaging using two-photon laser-scanning microscopy. Cold Spring Harb Protoc. 2012 Dec 1 (12). doi:pii: pdb.prot072249. 10.1101/pdb.prot072249. PMID: 23209137

Kirchhoff F, Debarbieux F, Kronland-Martinet C, Cojocaru GR, Popa-Wagner A. (2012) Combined two-photon laser-scanning microscopy and spectral microCT X-ray imaging to characterize the cellular signature and evolution of microstroke foci. Rom J Morphol Embryol. 53: 671-5. PMID: 23188424

Dibaj P, Zschüntzsch J, Steffens H, Scheffel J, Göricke B, Weishaupt JH, Le Meur K, Kirchhoff F, Hanisch UK, Schomburg ED, Neusch C. (2012) Influence of Methylene Blue on Microglia-Induced Inflammation and Motor Neuron Degeneration in the SOD1(G93A) Model for ALS. PLoS One 7:e43963. PMID: 22952827

Saab AS, Neumeyer A, Jahn HM, Cupido A, Šimek AA, Boele HJ, Scheller A, Le Meur K, Götz M, Monyer H, Sprengel R, Rubio ME, Deitmer JW, De Zeeuw CI, Kirchhoff F. (2012) Bergmann glial AMPA receptors are required for fine motor coordination. Science 337:749-53. PMID: 22767895

Tchorz JS, Tome M, Cloëtta D, Sivasankaran B, Grzmil M, Huber RM, Rutz-Schatzmann F, Kirchhoff F, Schaeren-Wiemers N, Gassmann M, Hemmings BA, Merlo A, Bettler B (2012) Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry. Cell Death Dis. 3:e325. PMID: 22717580

Ertürk A, Mauch CP, Hellal F, Förstner F, Keck T, Becker K, Jährling N, Steffens H, Richter M, Hübener M, Kramer E, Kirchhoff F, Dodt HU, Bradke F (2012) Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury. Nat Medicine. 18:166-71. PMID: 22198277

Guo J, Niu R, Huang W, Zhou M, Shi J, Zhang L, Liao H. (2012) Growth factors from tumor microenvironment possibly promote the proliferation of glioblastoma-derived stem-like cells in vitro. Pathol Oncol Res. 18: 1047-57. PMID: 22996727

Vinueza Veloz MF, Buijsen RA, Willemsen R, Cupido A, Bosman LW, Koekkoek SK, Potters JW, Oostra BA, De Zeeuw CI. (2012) The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice. Genes Brain Behav. 11: 325-31. PMID: 22257369

 

2011

Steffens H, Nadrigny F and Kirchhoff F (2011) Two-Photon Imaging of Neurons and Glia in the Spinal Cord In Vivo. Imaging in Neuroscience: A Laboratory Manual. pp. 715-727. Cold Spring Harbor Laboratory.

Lioy DT, Garg SK, Monaghan CE, Raber J, Foust KD, Kaspar BK, Hirrlinger PG, Kirchhoff F, Bissonnette JM, Ballas N, Mandel G (2011) A role for glia in the progression of Rett's syndrome. Nature 475: 497-500. PMID: 21716289

Herzog E, Nadrigny F, Silm K, Biesemann C, Helling I, Bersot T, Steffens H, Schwartzmann R, Nägerl UV, El Mestikawy S, Rhee J, Kirchhoff F, Brose N (2011) In vivo imaging of intersynaptic vesicle exchange using VGLUT1 Venus knock-in mice. J Neurosci. 31:15544-59. PMID: 22031900

Dibaj P, Steffens H, Zschüntzsch J, Kirchhoff F, Schomburg ED, Neusch C (2011) In vivo imaging reveals rapid morphological reactions of astrocytes towards focal lesions in an ALS mouse model. Neurosci Lett. 497:148-51. PMID: 21539893

Dibaj P, Steffens H, Zschuntzsch J, Nadrigny F, Schomburg ED, Kirchhoff F, Neusch C (2011) In Vivo Imaging Reveals Distinct Inflammatory Activity of CNS Microglia versus PNS Macrophages in a Mouse Model for ALS. Plos One 6:e17910. PMID: 21437247

Perez-Cruz C, Nolte MW, van Gaalen MM, Rustay NR, Termont A, Tanghe A, Kirchhoff F, Ebert U (2011) Reduced Spine Density in Specific Regions of CA1 Pyramidal Neurons in Two Transgenic Mouse Models of Alzheimer's Disease. J Neurosci 31:3926-3934. PMID: 21389247

Dibaj P, Steffens H, Nadrigny F, Kirchhoff F, Schomburg ED (2011) Purinergic activation of dorsal root ganglion neurones in vivo. Neurosci Lett 487:107-109. PMID: 20937358

 

2010

Reyes-Haro D, Müller J, Boresch M, Pivneva T, Benedetti B, Scheller A, Nolte C, Kettenmann H. (2010) Neuron-astrocyte interactions in the medial nucleus of the trapezoid body. J Gen Physiol. Jun;135: 583-94. PMID: 20479112

Beckervordersandforth R, Tripathi P, Ninkovic J, Bayam E, Lepier A, Stempfhuber B, Kirchhoff F, Hirrlinger J, Haslinger A, Lie DC, Beckers J, Yoder B, Irmler M, Gotz M (2010) In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells. Cell Stem Cell 7:744-758. PMID: 21112568

Dibaj P, Steffens H, Nadrigny F, Neusch C, Kirchhoff F, Schomburg ED (2010) Long-lasting post-mortem activity of spinal microglia in situ in mice. J Neurosci Res 88:2431-2440. PMID: 20623536

Dibaj P, Nadrigny F, Steffens H, Scheller A, Hirrlinger J, Schomburg ED, Neusch C, Kirchhoff F (2010) NO mediates microglial response to acute spinal cord injury under ATP control in vivo. Glia 58:1133-1144. PMID: 20468054

Heneka MT, Nadrigny F, Regen T, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch UK, Kummer MP (2010) Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine. Proc Natl Acad Sci U S A 107:6058-6063. PMID: 20231476

Kirchhoff F (2010) Questionable Calcium. Science 327:1212-1213. PMID: 20203041

Reichenbach A, Derouiche A, Kirchhoff F (2010) Morphology and dynamics of perisynaptic glia. Brain Res Rev 63:11-25. PMID: 20176054

 

2009

Hirrlinger J, Scheller A, Hirrlinger PG, Kellert B, Tang W, Wehr MC, Goebbels S, Reichenbach A, Sprengel R, Rossner MJ, Kirchhoff F (2009) Split-cre complementation indicates coincident activity of different genes in vivo. Plos One 4:e4286. PMID: 19172189

Neher RA, Mitkovski M, Kirchhoff F, Neher E, Theis FJ, Zeug A (2009) Blind source separation techniques for the decomposition of multiply labeled fluorescence images. Biophys J 96:3791-3800. PMID: 19413985

Ylera B, Erturk A, Hellal F, Nadrigny F, Hurtado A, Tahirovic S, Oudega M, Kirchhoff F, Bradke F (2009) Chronically CNS-injured adult sensory neurons gain regenerative competence upon a lesion of their peripheral axon. Curr Biol 19:930-936. PMID: 19409789

 

2008

Dimou L, Simon C, Kirchhoff F, Takebayashi H, Gotz M (2008) Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex. J Neurosci 28:10434-10442. PMID: 18842903

Hamilton N, Vayro S, Kirchhoff F, Verkhratsky A, Robbins J, Gorecki DC, Butt AM (2008) Mechanisms of ATP- and glutamate-mediated calcium signaling in white matter astrocytes. Glia 56:734-749. PMID: 18293404

Lalo U, Pankratov Y, Wichert SP, Rossner MJ, North RA, Kirchhoff F, Verkhratsky A (2008) P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes. J Neurosci 28:5473-5480. PMID: 18495881

Wolf F, Kirchhoff F (2008) Neuroscience. Imaging astrocyte activity. Science 320:1597-1599. PMID: 18566273

 

2007

Chvatal A, Anderova M, Hock M, Prajerova I, Neprasova H, Chvatal V, Kirchhoff F, Sykova E (2007) Three-dimensional confocal morphometry reveals structural changes in astrocyte morphology in situ. J Neurosci Res 85:260-271. PMID: 17086549

Chvatal A, Anderova M, Kirchhoff F (2007) Three-dimensional confocal morphometry - a new approach for studying dynamic changes in cell morphology in brain slices. J Anat 210:671-683. PMID: 17488344

Dibaj P, Kaiser M, Hirrlinger J, Kirchhoff F, Neusch C (2007) Kir4.1 channels regulate swelling of astroglial processes in experimental spinal cord edema. J Neurochem 103:2620-8. PMID: 17953658

Giaume C, Kirchhoff F, Matute C, Reichenbach A, Verkhratsky A (2007) Glia: the fulcrum of brain diseases. Cell Death Differ 14:1324-1335.  PMID: 17431421

Nadrigny F, Li D, Kemnitz K, Ropert N, Koulakoff A, Rudolph S, Vitali M, Giaume C, Kirchhoff F, Oheim M (2007) Systematic colocalization errors between acridine orange and EGFP in astrocyte vesicular organelles. Biophys J 93:969-980. PMID: 17416619

Oertel J, Villmann C, Kettenmann H, Kirchhoff F, Becker CM (2007) A novel glycine receptor beta subunit splice variant predicts an unorthodox transmembrane topology. Assembly into heteromeric receptor complexes. J Biol Chem 282:2798-2807. PMID: 17145751

Verkhratsky A, Kirchhoff F (2007) Glutamate-mediated neuronal-glial transmission. J Anat 210:651-660. PMID: 17504269

Verkhratsky A, Kirchhoff F (2007) NMDA Receptors in glia. Neuroscientist 13:28-37. PMID: 17229973

Wigley R, Hamilton N, Nishiyama A, Kirchhoff F, Butt AM (2007) Morphological and physiological interactions of NG2-glia with astrocytes and neurons. J Anat 210:661-670. PMID: 17459143

Winter SM, Hirrlinger J, Kirchhoff F, Hulsmann S (2007) Transgenic expression of fluorescent proteins in respiratory neurons. Respir Physiol Neurobiol 159:108-114. PMID: 17616445

Wu Q, Butzkueven H, Gresle M, Kirchhoff F, Friedhuber A, Yang Q, Wang H, Fang K, Lei H, Egan GF, Kilpatrick TJ (2007) MR diffusion changes correlate with ultra-structurally defined axonal degeneration in murine optic nerve. Neuroimage 37:1138-1147. PMID: 17689104

 

2006

Faure J, Lachenal G, Court M, Hirrlinger J, Chatellard-Causse C, Blot B, Grange J, Schoehn G, Goldberg Y, Boyer V, Kirchhoff F, Raposo G, Garin J, Sadoul R (2006) Exosomes are released by cultured cortical neurones. Mol Cell Neurosci 31:642-648. PMID: 16446100

Hirrlinger PG, Scheller A, Braun C, Hirrlinger J, Kirchhoff F (2006) Temporal control of gene recombination in astrocytes by transgenic expression of the tamoxifen-inducible DNA recombinase variant CreERT2. Glia 54:11-20. PMID: 16575885

Houades V, Rouach N, Ezan P, Kirchhoff F, Koulakoff A, Giaume C (2006) Shapes of astrocyte networks in the juvenile brain. Neuron Glia Biol 2:3-14. PMID: 18634587

Kaiser M, Maletzki I, Hulsmann S, Holtmann B, Schulz-Schaeffer W, Kirchhoff F, Bahr M, Neusch C (2006) Progressive loss of a glial potassium channel (KCNJ10) in the spinal cord of the SOD1 (G93A) transgenic mouse model of amyotrophic lateral sclerosis. J Neurochem 99:900-912. PMID: 16925593

Lalo U, Pankratov Y, Kirchhoff F, North RA, Verkhratsky A (2006) NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes. J Neurosci 26:2673-2683. PMID: 16525046

Lu YB, Franze K, Seifert G, Steinhauser C, Kirchhoff F, Wolburg H, Guck J, Janmey P, Wei EQ, Kas J, Reichenbach A (2006) Viscoelastic properties of individual glial cells and neurons in the CNS. Proc Natl Acad Sci U S A 103:17759-17764. PMID: 17093050

Nadrigny F, Rivals I, Hirrlinger PG, Koulakoff A, Personnaz L, Vernet M, Allioux M, Chaumeil M, Ropert N, Giaume C, Kirchhoff F, Oheim M (2006) Detecting fluorescent protein expression and co-localisation on single secretory vesicles with linear spectral unmixing. Eur Biophys J 35:533-547. PMID: 16568270

Neusch C, Papadopoulos N, Muller M, Maletzki I, Winter SM, Hirrlinger J, Handschuh M, Bahr M, Richter DW, Kirchhoff F, Hulsmann S (2006) Lack of the Kir4.1 channel subunit abolishes K+ buffering properties of astrocytes in the ventral respiratory group: impact on extracellular K+ regulation. J Neurophysiol 95:1843-1852. PMID: 16306174

Oheim M, Kirchhoff F, Stuhmer W (2006) Calcium microdomains in regulated exocytosis. Cell Calcium 40:423-439. PMID: 17067670

 

2005

Hirrlinger J, Moeller H, Kirchhoff F, Dringen R (2005) Expression of multidrug resistance proteins (Mrps) in astrocytes of the mouse brain: a single cell RT-PCR study. Neurochem Res 30:1237-1244. PMID: 16341585

Hirrlinger PG, Scheller A, Braun C, Quintela-Schneider M, Fuss B, Hirrlinger J, Kirchhoff F (2005) Expression of reef coral fluorescent proteins in the central nervous system of transgenic mice. Mol Cell Neurosci 30:291-303. PMID: 16169246

Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314-1318. PMID: 15831717

 

2004

Grass D, Pawlowski PG, Hirrlinger J, Papadopoulos N, Richter DW, Kirchhoff F, Hulsmann S (2004) Diversity of functional astroglial properties in the respiratory network. J Neurosci 24:1358-1365. PMID: 14960607

Hirrlinger J, Hulsmann S, Kirchhoff F (2004) Astroglial processes show spontaneous motility at active synaptic terminals in situ. Eur J Neurosci 20:2235-2239. PMID: 15450103

Nimmerjahn A, Kirchhoff F, Kerr JN, Helmchen F (2004) Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo. Nat Methods 1:31-37. PMID: 14782150

 

2003

Huttmann K, Sadgrove M, Wallraff A, Hinterkeuser S, Kirchhoff F, Steinhauser C, Gray WP (2003) Seizures preferentially stimulate proliferation of radial glia-like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis. Eur J Neurosci 18:2769-2778. PMID: 14656326

Malatesta P, Hack MA, Hartfuss E, Kettenmann H, Klinkert W, Kirchhoff F, Gotz M (2003) Neuronal or glial progeny: regional differences in radial glia fate. Neuron 37:751-764. PMID: 12628166

Matthias K, Kirchhoff F, Seifert G, Huttmann K, Matyash M, Kettenmann H, Steinhauser C (2003) Segregated expression of AMPA-type glutamate receptors and glutamate transporters defines distinct astrocyte populations in the mouse hippocampus. J Neurosci 23:1750-1758. PMID: 12629179

Wehner T, Bontert M, Eyupoglu I, Prass K, Prinz M, Klett FF, Heinze M, Bechmann I, Nitsch R, Kirchhoff F, Kettenmann H, Dirnagl U, Priller J (2003) Bone marrow-derived cells expressing green fluorescent protein under the control of the glial fibrillary acidic protein promoter do not differentiate into astrocytes in vitro and in vivo. J Neurosci 23:5004-5011. PMID: 12832523

 

2002

Schipke CG, Boucsein C, Ohlemeyer C, Kirchhoff F, Kettenmann H (2002) Astrocyte Ca2+ waves trigger responses in microglial cells in brain slices. FASEB J 16:255-257. PMID: 11772946

 

2001

Diers-Fenger M, Kirchhoff F, Kettenmann H, Levine JM, Trotter J (2001) AN2/NG2 protein-expressing glial progenitor cells in the murine CNS: isolation, differentiation, and association with radial glia. Glia 34:213-228. PMID: 11329183

Kirchhoff F, Dringen R, Giaume C (2001) Pathways of neuron-astrocyte interactions and their possible role in neuroprotection. Eur Arch Psychiatry Clin Neurosci 251:159-169. PMID: 11692580

Nolte C, Matyash M, Pivneva T, Schipke CG, Ohlemeyer C, Hanisch UK, Kirchhoff F, Kettenmann H (2001) GFAP promoter-controlled EGFP-expressing transgenic mice: a tool to visualize astrocytes and astrogliosis in living brain tissue. Glia 33:72-86. PMID: 11169793

Schipke CG, Ohlemeyer C, Matyash M, Nolte C, Kettenmann H, Kirchhoff F (2001) Astrocytes of the mouse neocortex express functional N-methyl-D-aspartate receptors. FASEB J 15:1270-1272. PMID: 11344110

Synowitz M, Ahmann P, Matyash M, Kuhn SA, Hofmann B, Zimmer C, Kirchhoff F, Kiwit JC, Kettenmann H (2001) GABA(A)-receptor expression in glioma cells is triggered by contact with neuronal cells. Eur J Neurosci 14:1294-1302. PMID: 11703458

 

2000

Fuss B, Mallon B, Phan T, Ohlemeyer C, Kirchhoff F, Nishiyama A, Macklin WB (2000) Purification and analysis of in vivo-differentiated oligodendrocytes expressing the green fluorescent protein. Dev Biol 218:259-274. PMID: 10656768

 

1999

Condorelli DF, Conti F, Gallo V, Kirchhoff F, Seifert G, Steinhauser C, Verkhratsky A, Yuan X (1999) Expression and functional analysis of glutamate receptors in glial cells. Adv Exp Med Biol 468:49-67. PMID: 10635019

Kirischuk S, Kirchhoff F, Matyash V, Kettenmann H, Verkhratsky A (1999) Glutamate-triggered calcium signalling in mouse bergmann glial cells in situ: role of inositol-1,4,5-trisphosphate-mediated intracellular calcium release. Neuroscience 92:1051-1059. PMID: 10426545

Schmidt K, Eulitz D, Veh RW, Kettenmann H, Kirchhoff F (1999) Heterogeneous expression of voltage-gated potassium channels of the shaker family (Kv1) in oligodendrocyte progenitors. Brain Res 843:145-160. PMID: 10528121

 

1998

Prinz M, Hanisch UK, Kettenmann H, Kirchhoff F (1998) Alternative splicing of mouse IL-15 is due to the use of an internal splice site in exon 5. Brain Res Mol Brain Res 63:155-162. PMID: 9838089

Schmidt-Ott KM, Tuschick S, Kirchhoff F, Verkhratsky A, Liefeldt L, Kettenmann H, Paul M (1998) Single-cell characterization of endothelin system gene expression in the cerebellum in situ. J Cardiovasc Pharmacol 31 Suppl 1:S364-S366. PMID: 9595483

 

1997

Hanisch UK, Lyons SA, Prinz M, Nolte C, Weber JR, Kettenmann H, Kirchhoff F (1997) Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity. J Biol Chem 272:28853-28860. PMID: 9360952

Kirchhoff F, Ohlemeyer C, Kettenmann H (1997) Expression of myelin-associated glycoprotein transcripts in murine oligodendrocytes. Neuroscience 78:561-570. PMID: 9145810

Moller T, Kann O, Prinz M, Kirchhoff F, Verkhratsky A, Kettenmann H (1997) Endothelin-induced calcium signaling in cultured mouse microglial cells is mediated through ETB receptors. Neuroreport 8:2127-2131. PMID: 9243597

Nolte C, Kirchhoff F, Kettenmann H (1997) Epidermal growth factor is a motility factor for microglial cells in vitro: evidence for EGF receptor expression. Eur J Neurosci 9:1690-1698. PMID: 9283823

Terness P, Welschof M, Moldenhauer G, Jung M, Moroder L, Kirchhoff F, Kipriyanov S, Little M, Opelz G (1997) Idiotypic vaccine for treatment of human B-cell lymphoma. Construction of IgG variable regions from single malignant B cells. Hum Immunol 56:17-27. PMID: 9455490

Tuschick S, Kirischuk S, Kirchhoff F, Liefeldt L, Paul M, Verkhratsky A, Kettenmann H (1997) Bergmann glial cells in situ express endothelinB receptors linked to cytoplasmic calcium signals. Cell Calcium 21:409-419. PMID: 9223677

 

1996

Kirchhoff F, Mulhardt C, Pastor A, Becker CM, Kettenmann H (1996) Expression of glycine receptor subunits in glial cells of the rat spinal cord. J Neurochem 66:1383-1390. PMID: 8627289

 

1994

Jabs R, Kirchhoff F, Kettenmann H, Steinhauser C (1994) Kainate activates Ca(2+)-permeable glutamate receptors and blocks voltage-gated K+ currents in glial cells of mouse hippocampal slices. Pflugers Arch 426:310-319. PMID: 8183642

 

1993

Fahrig T, Probstmeier R, Spiess E, Meyer-Franke A, Kirchhoff F, Drescher B, Schachner M (1993) Functional topography of the myelin-associated glycoprotein. I. Mapping of domains by electron microscopy. Eur J Neurosci 5:1118-1126. PMID: 7506618

Gimpl G, Kirchhoff F, Lang RE, Kettenmann H (1993) Identification of neuropeptide Y receptors in cultured astrocytes from neonatal rat brain. J Neurosci Res 34:198-205. PMID: 8450563

Kirchhoff F, Hofer HW, Schachner M (1993) Myelin-associated glycoprotein is phosphorylated by protein kinase C. J Neurosci Res 36:368-381. PMID: 7505837

 

1992

Kirchhoff F, Ohlemeyer C, Kettenmann H (1992) A fast perfusion system for single cell physiology optimized for microscopes with water immersion objectives. Pflugers Arch 420:573-577. PMID: 1614832

Kirchhoff F, Kettenmann H (1992) GABA Triggers a [Ca2+]i Increase in Murine Precursor Cells of the Oligodendrocyte Lineage. Eur J Neurosci 4:1049-1058. PMID: 12106410

 

1991

Schneider-Schaulies J, Kirchhoff F, Archelos J, Schachner M (1991) Down-regulation of myelin-associated glycoprotein on Schwann cells by interferon-gamma and tumor necrosis factor-alpha affects neurite outgrowth. Neuron 7:995-1005. PMID: 1722413

 

1990

Bartsch U, Kirchhoff F, Schachner M (1990) Highly sialylated N-CAM is expressed in adult mouse optic nerve and retina. J Neurocytol 19:550-565. PMID: 2243247

 

1989

Bartsch U, Kirchhoff F, Schachner M (1989) Immunohistological localization of the adhesion molecules L1, N-CAM, and MAG in the developing and adult optic nerve of mice. J Comp Neurol 284:451-462. PMID: 2474006

Sadoul R, Kirchhoff F, Schachner M (1989) A protein kinase activity is associated with and specifically phosphorylates the neural cell adhesion molecule L1. J Neurochem 53:1471-1478. PMID: 2677246