Molecular Neurophysiology
Publications
Bröker-Lai J*, Rego Terol J*, Richter C, Mathar I, Wirth A, Kopf S, Moreno-Pérez A, Büttner M, Tan LL, Makke M, Poschet G, Hermann J, Tsvilovskyy V, Haberkorn U, Wartenberg P, Susperreguy S, Berlin M, Ottenheijm R, Philippaert K, Wu M, Wiedemann T, Herzig S, Belkacemi A, Levinson RT, Agarwal N, Camacho Londoño JE, Klebl B, Dinkel K, Zufall F, Nussbaumer P, Boehm U, Hell R, Nawroth P, Birnbaumer L, Leinders-Zufall T, Kuner R, Zorn M, Bruns D, Schwarz Y+, Freichel M+. shared first (*) and last (+) authorships.
TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia.
EMBO J. 2024 Oct 7 doi
see also News and Views : TRPC5: a new entry to the chromaffin cell's palette of ion channels that control adrenal response to hypoglycemia.
EMBO J. 2024 Nov.1 doi
Mazen Makke, Alejandro Pastor Ruiz, Antonio Yarzagaray, Surya Gaya, Michelle Zimmer, Walentina Frisch, Dieter Bruns
Key determinants of the dual clamp/activator function of Complexin
https://doi.org/10.7554/eLife.92438.3
Kollewe A, Schwarz Y, Oleinikov K, Raza A, Haupt A, Wartenberg P, Wyatt A, Boehm U, Ectors F, Bildl W, Zolles G, Schulte U, Bruns D, Flockerzi V, Fakler B.
Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes.
Neuron. 2022 Oct 10 doi
Laporte MH, Chi KI, Caudal LC, Zhao N, Schwarz Y, Rolland M, Martinez-Hernandez J, Martineau M, Chatellard C, Denarier E, Mercier V, Lemaître F, Blot B, Moutaux E, Cazorla M, Perrais D, Lanté F, Bruns D, Fraboulet S, Hemming FJ, Kirchhoff F, Sadoul R.
Alix is required for activity-dependent bulk endocytosis at brain synapses.
PLoS Biol. 2022 Jun 3 doi
Knapp ML, Alansary D, Poth V, Förderer K, Sommer F, Zimmer D, Schwarz Y, Künzel N, Kless A, Machaca K, Helms V, Mühlhaus T, Schroda M, Lis A, Niemeyer BA.
A longer isoform of Stim1 is a negative SOCE regulator but increases cAMP-modulated NFAT signaling.
EMBO Rep. 2021 Dec 23 doi
Kamm GB, Boffi JC, Zuza K, Nencini S, Campos J, Schrenk-Siemens K, Sonntag I, Kabaoğlu B, El Hay MYA, Schwarz Y, Tappe-Theodor A, Bruns D, Acuna C, Kuner T, Siemens J.
A synaptic temperature sensor for body cooling.
Neuron. 2021 Oct 20 doi
Pick T, Beck A, Gamayun I, Schwarz Y, Schirra C, Jung M, Krause E, Niemeyer BA, Zimmermann R, Lang S, Anken EV, Cavalié A.
Remodelling of Ca2+ homeostasis is linked to enlarged endoplasmic reticulum in secretory cells.
Cell Calcium.2021 Sept 13 doi
Harb A, Vogel N, Shaib A, Becherer U, Bruns D, Mohrmann R.
Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons.
Front Mol Neurosci. 2021 Aug 23 doi
Ramesh G,Jarzembowski L, Schwarz Y, Poth V, Konrad M, Knapp ML, Schwär G, Lauer AA, Grimm MOW, Alansary D, Bruns D, Niemeyer BA.
A short isoform of STIM1 confers frequency- dependent synaptic enhancement.
Cell Rep.2021 doi
Schwarz Y, Oleinikov K, Schindeldecker B, Wyatt A, Weißgerber P, Flockerzi V, Boehm U, Freichel M, Bruns D.
TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses.
PLoS Biol. 2019,17(9). doi
Dhara M, Mantero Martinez M, Makke M, Schwarz Y, Mohrmann R, Bruns D.
Synergistic actions of v-SNARE transmembrane domains and membrane-curvature modifying lipids in neurotransmitter release
Elife. 2020 May 11 doi
Tian Q, Schröder L, Schwarz Y, Flockerzi A, Kaestner L, Zeug A, Bruns D, Lipp P.
Large scale, unbiased analysis of elementary calcium signaling events in cardiac myocytes.
J Mol Cell Cardiol. 2019, 135, 79-89. doi
Shaaban A, Dhara M, Frisch W, Harb A, Shaib AH, Becherer U, Bruns D, Mohrmann R.
The SNAP-25 linker supports fusion intermediates by local lipid interactions.
Elife. 2019; 8. doi
Makke M, Mantero Martinez M, Gaya S, Schwarz Y, Frisch W, Silva-Bermudez L, Jung M, Mohrmann R, Dhara M, Bruns D.
A mechanism for exocytotic arrest by the Complexin C-terminus.
Elife. 2018, 7, 38981. doi
Dhara M, Yarzagaray A, Makke M, Schindeldecker B, Schwarz Y, Shaaban A, Sharma S, Böckmann RA, Lindau M, Mohrmann R, Bruns D.
v-SNARE transmembrane domains function as catalysts for vesicle fusion.
Elife. 2016, 5. see Faculty of 1000,Biology signifiant contribution. doi
Bost A, Shaib AH, Schwarz Y, Niemeyer BA, Becherer U.
Large dense-core vesicle exocytosis from mouse dorsal root ganglion neurons is regulated by neuropeptide Y.
Neuroscience. 2017, 346, 1-13. doi
Schwarz Y, Zhao N, Kirchhoff F, Bruns D.
Astrocytes control synaptic strength by two distinct v-SNARE-dependent release pathways.
Nat Neurosci. 2017. 20, 1529-1539, see Faculty of 1000. doi
Dhara M, Mohrmann R, Bruns D.
v-SNARE function in chromaffin cells.
Pflugers Arch. 2018, 470, 169-180. doi
Bröker-Lai J, Kollewe A, Schindeldecker B, Pohle J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weißgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Köhr G, Fakler B, Flockerzi V, Bruns D, Freichel M.
Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory.
EMBO J. 2017, 36, 2770-2789. doi
Bruns D, Engert F, Lux HD.
A fast activating presynaptic reuptake current during serotonergic transmission in identified neurons of Hirudo.
Neuron. 1993, 10, 559-72. doi
Bruns D, Jahn R.
Real-time measurement of transmitter release from single synaptic vesicles.
Nature. 1995 , 377, 62-5. see also: Principles of Neuroscience, 4th edition, Editors Kandel E. R., Schwartz J.H, Jessel T.M., p.268. doi
Fasshauer D, Bruns D, Shen B, Jahn R, Brünger AT.
A structural change occurs upon binding of syntaxin to SNAP-25.
J Biol Chem. 1997, 272, 4582-90. doi
Bruns D, Engers S, Yang C, Ossig R, Jeromin A, Jahn R.
Inhibition of transmitter release correlates with the proteolytic activity of tetanus toxin and botulinus toxin A in individual cultured synapses of Hirudo medicinalis.
J Neurosci. 1997, 17, 1898-910. doi
Bruns D, Jahn R.
Monoamine transmitter release from small synaptic and large dense-core vesicles.
Adv Pharmacol. 1998, 42, 87-90. doi
Bruns D.
Serotonin transport in cultured leech neurons.
Methods Enzymol. 1998, 296, 593-607. doi
Bruns D, Riedel D, Klingauf J, Jahn R.
Quantal release of serotonin.
Neuron. 2000, 28, 205-20. doi
Bruns D, Jahn R.
Molecular determinants of exocytosis.
Pflugers Arch. 2002, 443, 333-8. doi
Hatsuzawa K, Lang T, Fasshauer D, Bruns D, Jahn R.
The R-SNARE motif of tomosyn forms SNARE core complexes with syntaxin 1 and SNAP-25 and down-regulates exocytosis.
J Biol Chem. 200, 278, 31159-66. doi
Yizhar O, Matti U, Melamed R, Hagalili Y, Bruns D, Rettig J, Ashery U.
Tomosyn inhibits priming of large dense-core vesicles in a calcium-dependent manner.
Proc Natl Acad Sci U S A. 2004, 101, 2578-83. doi
Bruns D.
Detection of transmitter release with carbon fiber electrodes.
Methods. 2004, 33, 312-21. doi
Borisovska M, Zhao Y, Tsytsyura Y, Glyvuk N, Takamori S, Matti U, Rettig J, Südhof T, Bruns D.
v-SNAREs control exocytosis of vesicles from priming to fusion.
EMBO J. 2005 Jun 15;24(12):2114-26. Epub 2005 May 26.doi
Schütz D, Zilly F, Lang T, Jahn R, Bruns D.
A dual function for Munc-18 in exocytosis of PC12 cells.
Eur J Neurosci. 2005, 21, 2419-32. doi
Speidel D, Bruederle CE, Enk C, Voets T, Varoqueaux F, Reim K, Becherer U, Fornai F, Ruggieri S, Holighaus Y, Weihe E, Bruns D, Brose N, Rettig J.
CAPS1 regulates catecholamine loading of large dense-core vesicles.
Neuron. 2005, 46, 75-88. doi
Kesavan J, Borisovska M, Bruns D.
v-SNARE actions during Ca(2+)-triggered exocytosis.
Cell. 2007 131, 351-63. See faculty of 1000, Major advances. doi
Liu Y, Schirra C, Stevens DR, Matti U, Speidel D, Hof D, Bruns D, Brose N, Rettig J.
CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles.
J Neurosci. 2008, 28, 5594-601. doi
Gross SA, Guzmán GA, Wissenbach U, Philipp SE, Zhu MX, Bruns D, Cavalié A.
TRPC5 is a Ca2+-activated channel functionally coupled to Ca2+-selective ion channels.
J Biol Chem. 2009, 284, 34423-32. doi
Walter AM, Wiederhold K, Bruns D, Fasshauer D, Sørensen JB.
Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis.
J Cell Biol. 2010, 188, 401-13. doi
Guzman RE, Schwarz Y, Rettig J, Bruns D.
SNARE force synchronizes synaptic vesicle fusion and controls the kinetics of quantal synaptic transmission.
J Neurosci. 2010, 30, 10272-81. doi
Liu Y, Schirra C, Edelmann L, Matti U, Rhee J, Hof D, Bruns D, Brose N, Rieger H, Stevens DR, Rettig J.
Two distinct secretory vesicle-priming steps in adrenal chromaffin cells.
J Cell Biol. 2010, 190, 1067-77. doi
Ngatchou AN, Kisler K, Fang Q, Walter AM, Zhao Y, Bruns D, Sørensen JB, Lindau M.
Role of the synaptobrevin C terminus in fusion pore formation.
Proc Natl Acad Sci U S A. 2010, 107, 18463-8. doi
Molecular Neurophysiology
Univ.-Prof. Dr.
Dieter Bruns
+49 6841/16-16494 | |
+49 6841/16-16492 |
Labmanager
Marina Roter
Saarland University
Faculty of Medicine
Institut of Physiology
Univ.-Prof. Dr. Dieter Bruns
CIPMM | Building 48
D-66421 Homburg