Publications 2023

Identification of molecular candidates which regulate calcium-dependent CD8+ T-cell cytotoxicity.
Sylvia Zöphel, Gertrud Schäfer, Maryam Nazarieh, Verena Konetzki, Cora Hoxha, Eckart Meese, Markus Hoth, Volkhard Helms, Mohamed Hamed, Eva C Schwarz
Mol Immunol. 2023 May;157:202-213. doi: 10.1016/j.molimm.2023.04.002. Epub 2023 Apr 17.

Publications 2022

B-cell receptors of EBV-negative Burkitt lymphoma bind modified isoforms of autoantigens.
Bock T, Bewarder M, Cetin O, Fadle N, Regitz E, Schwarz EC, Held J, Roth S, Lohse S, Pfuhl T, Wagener R, Smola S, Becker SL, Bohle RM, Trumper L, Siebert R, Hansmann ML, Pfreundschuh M, Drexler HG, Hoth M, Kubuschok B, Roemer K, Preuss KD, Hartmann S, Thurner L.
(2022) EJHaem 3, 739-747. doi.org/10.1002/jha2.475.

Interdependence of sequential cytotoxic T lymphocyte and natural killer cell cytotoxicity against melanoma cells.
Friedmann KS, Kaschek L, Knörck A, Cappello S, Lünsmann N, Küchler N, Hoxha C, Schäfer G, Iden S, Bogeski I, Kummerow C, Schwarz EC, Hoth M.
J Physiol. 2022 Dec;600(23):5027-5054. doi: 10.1113/JP283667. Epub 2022 Nov 3.

Cytotoxic Efficiency of Human CD8(+) T Cell Memory Subtypes.
Knorck A, Schafer G, Alansary D, Richter J, Thurner L, Hoth M, Schwarz EC.
Front. Immunol., 13 April 2022 Sec.T Cell Biology

Unspecific CTL Killing Is Enhanced by High Glucose via TNF-Related Apoptosis-Inducing Ligand.
Yang W, Denger A, Diener C, Kuppers F, Soriano-Baguet L, Schafer G, Yanamandra AK, Zhao R, Knorck A, Schwarz EC, Hart M, Lammert F, Roma LP, Brenner D, Christidis G, Helms V, Meese E, Hoth M, Qu B.
Front. Immunol., 21 February 2022 Sec.T Cell Biology

Publications 2021

Targeting the Microtubule-Network Rescues CTL Killing Efficiency in Dense 3D Matrices.
Zhao R, Zhou X, Khan ES, Alansary D, Friedmann KS, Yang W, Schwarz EC, Del Campo A, Hoth M, Qu B.
Front. Immunol., 17 August 2021 Sec.T Cell Biology

High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity.
Zhu J, Yang W, Zhou X, Zöphel D, Soriano-Baguet L, Dolgener D, Carlein C, Hof C, Zhao R, Ye S, Schwarz EC, Brenner D, Prates Roma L, Qu B.
Front Immunol. 2021 Jun 25;12:689337. doi: 10.3389/fimmu.2021.689337. eCollection 2021. PMID: 34248978 Free PMC article.

Publications 2020

High glucose distinctively regulates Ca2+ influx in cytotoxic T lymphocytes upon target recognition and thapsigargin stimulation.
Zou H, Yang W, Schwär G, Zhao R, Alansary D, Yin D, Schwarz EC, Niemeyer BA, Qu B.
Eur J Immunol. 2020 Dec;50(12):2095-2098. doi: 10.1002/eji.202048577. Epub 2020 Aug 1

Interorganelle Tethering to Endocytic Organelles Determines Directional Cytokine Transport in CD4+ T Cells.
Zhou Y, Zhao R, Schwarz EC, Akbar R, Kaba M, Pattu V, Helms V, Rieger H, Nunes-Hasler P, Qu B.
J Immunol. 2020 Dec 1;205(11):2988-3000. doi: 10.4049/jimmunol.2000195. Epub 2020 Oct 26

Publications 2019

Macrophage Polarization is Deregulated in Haemophilia.
Knowles LM, Kagiri D, Bernard M, Schwarz EC, Eichler H, Pilch J.
Thromb Haemost. 2019 Feb;119(2):234-245. doi: 10.1055/s-0038-1676796. Epub 2019 Jan 16

The histone demethylase PHF8 facilitates alternative splicing of the histocompatibility antigen HLA-G.
Leisegang MS, Gu L, Preussner J, Günther S, Hitzel J, Ratiu C, Weigert A, Chen W, Schwarz EC, Looso M, Fork C, Brandes RP.
Febs Letters. 2019 Feb 13; 539(5):487-498. doi: 10.1002/1873-3468.13337

miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling.
Hart M, Walch-Rückheim B, Friedmann KS, Rheinheimer S, Tänzer T, Glombitza B, Sester M, Lenhof HP, Hoth M, Schwarz EC, Keller A, Meese E.
Cell Death Dis. 2019 Jan 18;10(2):46. doi: 10.1038/s41419-018-1295-1.

Publications 2018

Quantity, quality, and functionality of peripheral blood cells derived from residual blood of different apheresis kits.
Knörck A, Marx S, Friedmann KS, Zöphel S, Lieblang L, Hässig C, Müller I, Pilch J, Sester U, Hoth M, Eichler H, Sester M, Schwarz EC.
Transfusion. 2018 Jun;58(6):1516-1526. doi: 10.1111/trf.14616. Epub 2018 May 6.

A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity.
Zhou X, Friedmann KS, Lyrmann H, Zhou Y, Schoppmeyer R, Knörck A, Mang S, Hoxha C, Angenendt A, Backes CS, Mangerich C, Zhao R, Cappello S, Schwär G, Hässig C, Neef M, Bufe B, Zufall F, Kruse K, Niemeyer BA, Lis A, Qu B, Kummerow C, Schwarz EC, Hoth M.
J Physiol. 2018 Jan 25. doi: 10.1113/JP274964. [Epub ahead of print]

Publications 2017

Human profilin 1 is a negativ regulator of CTL mediated cell-killing and migration.
Schoppmeyer R, Zhao R, Cheng H, Hamed M, Liu C, Zhou X, Schwarz EC, Zhou Y, Knörck A, Schwär G, Ji S, Liu L, Long J, Helms V, Hoth M, Yu X, Qu B.
Eur J Immunol. 2017;47:1562-1572. Epub ahead of print.

Bystander cells enhance NK cytotoxic efficiency by reducing search time.
Zhou X, Zhao R, Schwarz K, Mangeat M, Schwarz EC, Hamed M, Bogeski I, Helms V, Rieger H, Qu B.
Scientific Reports. 2017 Mar 13;7(44357)

The extracellular adherence protein (Eap) of Staphylococcus aureus acts as a proliferation and migration repressing factor that alters the cell morphology of keratinocytes.
Eisenbeis J, Peisker H, Backes CS, Bur S, Hölters S, Thewes N, Greiner M, Junker C, Schwarz EC, Hoth M, Junker K, Preissner KT, Jacobs K, Herrmann M, Bischoff M.
Int J Med Microbiol. 2017 Jan 18. pii: S1438-4221(17)30026-7. doi: 10.1016/j.ijmm.2017.01.002. [Epub ahead of print]

Publications 2016

Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes.
Bhat SS,Friedmann KS, Knörck, Hoxha C, Leidinger P, Backes C, Meese E, Keller A, Rettig J, Hoth M, Qu B, Schwarz EC.
Biochim Biophys Acta - Molecular Cell Research. 2016 Jul;Vol. 1863, Issue 7 Part A:pp 1653-1664

A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.
Saul S, Gibhardt CS, Schmidt B, Lis A, Pasieka B, Conrad D, Jung P, Gaupp R, Wonnenberg B, Diler E, Stanisz H, Vogt T, Schwarz EC, Bischoff M, Herrmann M, Tschernig T, Kappl R, Rieger H, Niemeyer BA, Bogeski I.
Sci Signal. 2016 Mar 8;9(418):ra26.

Deep characterization of blood cell miRNomes by NGS.
Schwarz EC, Backes C, Knörck A, Ludwig N, Leidinger P, Hoxha C, Schwär G, Grossmann T, Müller SC, Hart M, Haas J, Galata V, Müller I, Fehlmann T, Eichler H, Franke A, Meder B, Meese E, Hoth M, Keller A.
Cell Mol Life Sci. 2016 Feb 13. [Epub ahead of print]

Publications 2014

A simple, economic, time-resolved killing assay.
Kummerow C, Schwarz EC, Bufe B, Zufall F, Hoth M, Qu B.
Eur J Immunol. 2014 Jun;44(6):1870-2. doi: 10.1002/eji.201444518. Epub 2014 Apr 13.

How ORAI and TRP channels interfere with each other: interaction models and examples from the immune system and the skin.
Saul S, Stanisz H, Backes CS, Schwarz EC, Hoth M.
Eur J Pharmacol. 2014 Sep 15;739:49-59. doi: 10.1016/j.ejphar.2013.10.071. Epub 2013 Nov 28.

Syntaxin11 serves as a t-SNARE for the fusion of lytic granules in human cytotoxic T lymphocytes.
Halimani M, Pattu V, Marshall MR, Chang HF, Matti U, Jung M, Becherer U, Krause E, Hoth M, Schwarz EC, Rettig J.
Eur J Immunol. 2014 Feb;44(2):573-84. doi: 10.1002/eji.201344011. Epub 2013 Dec 16.

Publications 2013

ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer.
Holzmann C, Kilch T, Kappel S, Armbrüster A, Jung V, Stöckle M, Bogeski I, Schwarz EC, Peinelt C.
Oncotarget. 2013 Nov;4(11):2096-107.

Calcium, cancer and killing: the role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells.
Schwarz EC, Qu B, Hoth M.
Biochim Biophys Acta. 2013 Jul;1833(7):1603-11. Epub 2012 Dec 3. Review.

Publications 2012

ORAI1 Ca(2+) channels control endothelin-1-induced mitogenesis and melanogenesis in primary human melanocytes.
Stanisz H, Stark A, Kilch T, Schwarz EC, Müller CS, Peinelt C, Hoth M, Niemeyer BA, Vogt T, Bogeski I.
Journal of Investigative Dermatology. 2012 May; 132(5): 1443–1451.

SNARE protein expression and localization in human cytotoxic T lymphocytes.
Pattu V, Qu B, Schwarz EC, Strauβ B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M.
Eur J Immunol. 2012 Feb;42(2):470-5. doi: 10.1002/eji.201141915. Epub 2012 Jan 5.

Publications 2011

Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes.
Pattu V, Qu B, Marshall M, Becherer U, Junker C, Matti U, Schwarz EC, Krause E, Hoth M, Rettig J.
Traffic. 2011 Jul;12(7):890-901. doi: 10.1111/j.1600-0854.2011.01193.x. Epub 2011 Apr 21.

Docking of Lytic Granules at the Immunological Synapse in Human CTL Requires Vti1b-Dependent Pairing with CD3 Endosomes.
Qu B, Pattu V, Junker C, Schwarz EC, Bhat SS, Kummerow C, Marshall M, Matti U, Neumann F, Pfreundschuh M, Becherer U, Rieger H, Rettig J, Hoth M.
J Immunol. 2011 Jun 15;186(12):6894-904. Epub 2011 May 11.

ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance.
Qu B, Al-Ansary D, Kummerow C, Hoth M, Schwarz EC.
Cell Calcium. 2011 Jun 10. [Epub ahead of print]

TRP expression pattern and the functional importance of TRPC3 in primary human T-cells.
Wenning AS, Neblung K, Strauß B, Wolfs MJ, Sappok A, Hoth M, Schwarz EC.
Biochim Biophys Acta. (2011 Mar);1813(3):412-23. Epub 2011 Jan 4.

Publications 2010

A myosin IK-Abp1-PakB circuit acts as a switch to regulate phagocytosis efficiency.

Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling.
Bogeski I, Kummerov C, Al-Ansary D, Schwarz EC, Koehler R, Kozai D, Takahashi N, Peinelt C, Griesemer D, Bozem M, Mori Y, Hoth M, Niemeyer BA.
Sci Signal. (2010 Mar 30);3 (115):ra24.

Efficiency of T-cell co-stimulation by CD80 and CD86 cross-linking correlates with calcium entry.
Thiel M, Wolfs M-J, Bauer S, Wenning AS, Burckhart T, Schwarz EC, Scott AM, Renner C, Hoth M.
Immunology (2010 Jan);129(1):28-40. Epub 2009 Oct 12.

Publications 2007

Calcium dependence of T-cell proliferation following focal stimulation.
Schwarz EC, Kummerow C, Wennings AS, Wagner K, Waggershauser K, Griesemer D, Staruß B, Wolfs M-J, Quintana A, Hoth M.
Eur. J. Immunol. (2007 Sep 26);37(10):2723-2733

T cell activation requires mitochondrial translocation to the immunological synapse.
Quintana A, Schwindling C, Wenning AS, Becherer U, Rettig J, Schwarz EC, Hoth M.
Proc. Natl. Acad. Sci. USA. (2007 Sep 4);104(36):14418-14423

TRP channels in lymphocytes.
Schwarz EC, Wolfs MJ, Tonner S, Wenning A, Quintana A, Griesemer D, Hoth M.
Handb. Exp. Pharmacol. (2007 Feb);179:445-456

Publications 2006

Sustained activity of CRAC channels requires translocation of mitochondria to the plasma membrane.
Quintana A, Schwarz EC, Schwindling C, Lipp P, Kaestner L, Hoth M.
J. Biol. Chem. (2006 Dec 29);281:40302-40309

CRAC calcium channels as signal transducers in T-cells.
Griesemer D, Löffler B, Kummerow C, Quintana A, Schwarz EC, Hoth M.
Signal Transduction (2006 July 11);6(4):233-239

TRPV6 potentiates calcium-dependent cell proliferation.
Schwarz EC, Wissenbach U, Niemeyer BA, Strauß B, Philipp SE, Flockerzi V, Hoth M.
Cell Calcium (2006 Feb);39(2):163-173

Publications 2005

Calcium-dependent activation of T-lymphoctes.
Quintana A, Griesemer D, Schwarz EC, Hoth M.
Eur. J. Physiol. Pflügers Arch. (2005 April);450(1):1-12

Publications 2004

Potent inhibition of CRAC channels and T-lymphocyte activation by the pyrazole derivative BTP2.
Zitt C, Strauß B, Schwarz EC, Spaeth N, Hatzelmann A, Hoth M.
J. Biol. Chem. (2004 Mar 26);279:12427-12437

Ca²⁺ signaling in identified lymphocytes from human intestine: relation to hyporeactivity, proliferation and inflammatory bowel disease.
Schwarz A, Tutsch E, Ludwig B, Schwarz EC, Stallmach A, Hoth M.
J. Biol. Chem. (2004 Feb 13);279:5641-5647