Publications 2023

Lis, A., Zöphel, D.
"Elderly CD8⁺ T cells in the focus for immunotherapeutic approaches"
Aging (Albany NY), 15, 3899-3900, (2023), DOI:10.18632/aging.204747, Pubmed-ID: 37204431.

Zöphel, D., Kaschek, L., Steiner, R., Janku, S., Chang, H., Lis, A.
"Heterozygous OT-I mice reveal that antigen-specific CD8⁺ T cells shift from apoptotic to necrotic killers in the elderly"
Aging Cell, 22, e13824-XXXXXX, (2023), DOI:10.1111/acel.13824, Pubmed-ID: 36947105.

Publications 2022

Zöphel, D., Angenendt, A., Kaschek, L., Ravichandran, K., Hof, C., Janku, S., Hoth, M., Lis, A.
"Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxic CD8⁺ T cells boost cancer cell elimination"
Aging Cell, 21, e13668-XXXXXX, (2022), DOI:10.1111/acel.13668, Pubmed-ID: 35818124.

Souza Bomfim, G. H. , Niemeyer, B.A., Lacruz, R.S., Lis, A.
"On the Connections between TRPM Channels and SOCE"
Cells, 11, 1190, (2022), DOI:10.3390/cells11071190, Pubmed-ID: 35406753.

Knapp, M. L. , Alansary, D., Poth, V., Förderer, K., Sommer, F., Zimmer, D., Schwarz, Y., Künzel, N., Kless, A., Machaca, K., Helms, V., Mühlhaus, T., Schroda, M., Lis, A., Niemeyer, B.A.
"A longer isoform of Stim1 is a negative SOCE regulator but increases cAMP-modulated NFAT signaling"
EMBO Rep, 23, e53135-XXXXXX, (2022), DOI:10.15252/embr.202153135, Pubmed-ID: 34942054.

Publications 2021

Ritzmann, F., Borchardt, K., Vella, G., Chitirala, P., Angenendt, A., Herr, C., Menger, M.D., Hoth, M., Lis, A., Bohle, R.M., Bals, R., Beisswenger, C.
"Blockade of PD-1 decreases neutrophilic inflammation and lung damage in experimental COPD"
Am J Physiol Lung Cell Mol Physiol, 320, L958-L968, (2021), DOI:10.1152/ajplung.00121.2020, Pubmed-ID: 33759577.

Publications 2020

Zöphel, D., Hof, C., Lis, A.
"Altered Ca²⁺ Homeostasis in Immune Cells during Aging: Role of Ion Channels"
Int J Mol Sci, 22, 110, (2020), DOI:10.3390/ijms22010110, Pubmed-ID: 33374304.

Angenendt, A., Steiner, R., Knörck, A., Schwär, G., Konrad, M., Krause, E., Lis, A.
"Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8⁺ T cells of elderly mice"
Aging (Albany NY), 12, 3266-3286, (2020), DOI:10.18632/aging.102809, Pubmed-ID: 32062611.

Publications 2019

Ritzmann, F., Jungnickel, C., Vella, G., Kamyschnikow, A., Herr, C., Li, D., Menger, M.M., Angenendt, A., Hoth, M., Lis, A., Bals, R., Beisswenger, C.
"IL-17C-mediated innate inflammation decreases the response to PD-1 blockade in a model of Kras-driven lung cancer"
Sci Rep, 9, 10353-XXXXX, (2019), DOI:10.1038/s41598-019-46759-8, Pubmed-ID: 31316109.

Frisch, J., Angenendt, A., Hoth, M., Prates Roma, L., Lis, A.
"STIM-Orai Channels and Reactive Oxygen Species in the Tumor Microenvironment"
Cancers (Basel), 11, 457, (2019), DOI:10.3390/cancers11040457, Pubmed-ID: 30935064.

Publications 2018

Suzuki, S., Lis, A., Schmitz, C., Penner, R., Fleig, A.
"The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins"
Cell Mol Life Sci, 75, 3069-3078, (2018), DOI:10.1007/s00018-018-2786-z, Pubmed-ID: 29500477.

Przibilla, J., Dembla, S., Rizun, O., Lis, A., Jung, M., Oberwinkler, J., Beck, A., Philipp, S.E.
"Ca²⁺-dependent regulation and binding of calmodulin to multiple sites of Transient Receptor Potential Melastatin 3 (TRPM3) ion channels"
Cell Calcium, 73, 40-52, (2018), DOI:10.1016/j.ceca.2018.03.005, Pubmed-ID: 29880196.

Zhou, X., Friedmann, K.S., Lyrmann, H., Zhou, Y., Schoppmeyer, R., Knörck, A., Mang, S., Hoxha, C., Angenendt, A., Backes, C.S., Mangerich, C., Zhao, R., Cappello, S., Schwär, G., Hässig, C., Neef, M., Bufe, B., Zufall, F., Kruse, K., Niemeyer, B.A., Lis, A., Qu, B., Kummerow, C., Schwarz, E.C., Hoth, M.
"A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity"
J Physiol, 596, 2681-2698, (2018), DOI:10.1113/JP274964, Pubmed-ID: 29368348.

Publications 2016

Saul, S., Gibhardt, C.S., Schmidt, B., Lis, A., Pasieka, B., Conrad, D., Jung, P., Gaupp, R., Wonnenberg, B., Diler, E., Stanisz, H., Vogt, T., Schwarz, E.C., Bischoff, M., Herrmann, M., Tschernig, T., Kappl, R., Rieger, H., Niemeyer, B.A., Bogeski, I.
"A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels"
Sci Signal, 9, ra26-XXXX, (2016), DOI:10.1126/scisignal.aaf1639, Pubmed-ID: 26956485.

Publications 2014

Alansary, D., Kilch, T., Holzmann, C., Peinelt, C., Hoth, M., Lis, A.
"Patch-clamp measurement of ICRAC and ORAI channel activity"
Cold Spring Harb Protoc, 2014, 602-607, (2014), DOI:10.1101/pdb.top066795, Pubmed-ID: 24890214.

Alansary, D., Kilch, T., Holzmann, C., Peinelt, C., Hoth, M., Lis, A.
"The minimal requirements to use calcium imaging to analyze ICRAC"
Cold Spring Harb Protoc, 2014, 638-642, (2014), DOI:10.1101/pdb.prot073262, Pubmed-ID: 24890204.

Alansary, D., Kilch, T., Holzmann, C., Peinelt, C., Hoth, M., Lis, A.
"Measuring endogenous ICRAC and ORAI currents with the patch-clamp technique"
Cold Spring Harb Protoc, 2014, 630-637, (2014), DOI:10.1101/pdb.prot073254, Pubmed-ID: 24890203.

Publications 2013

Yu, H., Zhang, Z., Lis, A., Penner, R., Fleig, A.
"TRPM7 is regulated by halides through its kinase domain"
Cell Mol Life Sci, 70, 2757-2771, (2013), DOI:10.1007/s00018-013-1284-6, Pubmed-ID: 23471296.

Thiel, M., Lis, A., Penner, R.
"STIM2 drives Ca2+ oscillations through store-operated Ca2+ entry caused by mild store depletion"
J Physiol, 591, 1433-1445, (2013), DOI:10.1113/jphysiol.2012.245399, Pubmed-ID: 23359669.

Publications 2012

Frühwald, J., Camacho Londoño, J., Dembla, S., Mannebach, S., Lis, A., Drews, A., Wissenbach, U., Oberwinkler, J., Philipp, S.E.
"Alternative splicing of a protein domain indispensable for function of transient receptor potential melastatin 3 (TRPM3) ion channels"
J Biol Chem, 287, 36663-36672, (2012), DOI:10.1074/jbc.M112.396663, Pubmed-ID: 22961981.

Publications 2011

Lambert, S., Drews, A., Rizun, O., Wagner, T.F.J., Lis, A., Mannebach, S., Plant, S., Portz, M., Meissner, M., Philipp, S.E., Oberwinkler, J.
"Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions"
J Biol Chem, 286, 12221-12233, (2011), DOI:10.1074/jbc.M110.202945, Pubmed-ID: 21278253.

Publications 2010

Lis, A., Zierler, S., Peinelt, C., Fleig, A., Penner, R.
"A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating"
J Gen Physiol, 136, 673-686, (2010), DOI:10.1085/jgp.201010484, Pubmed-ID: 21115697.

Publications 2008

Wagner, T. F. J. , Loch, S., Lambert, S., Straub, I., Mannebach, S., Mathar, I., Düfer, M., Lis, A., Flockerzi, V., Philipp, S.E., Oberwinkler, J.
"Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells"
Nat Cell Biol, 10, 1421-1430, (2008), DOI:10.1038/ncb1801, Pubmed-ID: 18978782.

Peinelt, C., Lis, A., Beck, A., Fleig, A., Penner, R.
"2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels"
J Physiol, 586, 3061-3073, (2008), DOI:10.1113/jphysiol.2008.151365, Pubmed-ID: 18403424.

Parvez, S., Beck, A., Peinelt, C., Soboloff, J., Lis, A., Monteilh-Zoller, M., Gill, D.L., Fleig, A., Penner, R.
"STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation"
FASEB J, 22, 752-761, (2008), DOI:10.1096/fj.07-9449com, Pubmed-ID: 17905723.

Publications 2007

Lis, A., Peinelt, C., Beck, A., Parvez, S., Monteilh-Zoller, M., Fleig, A., Penner, R.
"CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties"
Curr Biol, 17, 794-800, (2007), DOI:10.1016/j.cub.2007.03.065, Pubmed-ID: 17442569.

Publications 2006

Vig, M., Beck, A., Billingsley, J.M., Lis, A., Parvez, S., Peinelt, C., Koomoa, D.L., Soboloff, J., Gill, D.L., Fleig, A., Kinet, J., Penner, R.
"CRACM1 multimers form the ion-selective pore of the CRAC channel"
Curr Biol, 16, 2073-2079, (2006), DOI:10.1016/j.cub.2006.08.085, Pubmed-ID: 16978865.

Peinelt, C., Vig, M., Koomoa, D.L., Beck, A., Nadler, M.J.S., Koblan-Huberson, M., Lis, A., Fleig, A., Penner, R., Kinet, J.
"Amplification of CRAC current by STIM1 and CRACM1 (Orai1)"
Nat Cell Biol, 8, 771-773, (2006), DOI:10.1038/ncb1435, Pubmed-ID: 16733527.

Publications 2005

Oberwinkler, J., Lis, A., Giehl, K.M., Flockerzi, V., Philipp, S.E.
"Alternative splicing switches the divalent cation selectivity of TRPM3 channels"
J Biol Chem, 280, 22540-22548, (2005), DOI:10.1074/jbc.M503092200, Pubmed-ID: 15824111.

Lis, A., Wissenbach, U., Philipp, S.E.
"Transcriptional regulation and processing increase the functional variability of TRPM channels"
Naunyn Schmiedebergs Arch Pharmacol, 371, 315-324, (2005), DOI:10.1007/s00210-005-1050-x, Pubmed-ID: 15856355.

Aneiros, E., Philipp, S., Lis, A., Freichel, M., Cavalié, A.
"Modulation of Ca2+ signaling by Na+/Ca2+ exchangers in mast cells"
J Immunol, 174, 119-130, (2005), DOI:10.4049/jimmunol.174.1.119, Pubmed-ID: 15611234.