Publications 2023

Elderly CD8+ T cells in the focus for immunotherapeutic approaches.
Annette Lis, Dorina Zöphel.
Aging (Albany NY). 2023 May 18;15(10):3899-3900. doi: 10.18632/aging.204747. Epub 2023 May 18.

Heterozygous OT-I mice reveal that antigen-specific CD8+ T cells shift from apoptotic to necrotic killers in the elderly.
Dorina Zöphel, Lea Kaschek, Romy Steiner, Sandra Janku, Hsin-Fang Chang, Annette Lis.
Aging Cell. 20023 Jun; 22(6):e13824. doi: 10.1111/acel.13824. Epub 2023 Mar 22.

Publications 2022

Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxic CD8+ T cells boost cancer cell elimination.
Zöphel D, Angenendt A, Kaschek L, Ravichandran K, Hof C, Janku S, Hoth M, Lis A.
Aging Cell. 2022 Aug; 21(8):e13668. doi: 10.1111/acel.13688. Epub 2022 Jul 11.

On the Connections between TRPM Channels and SOCE.
Souza Bomfim GH, Niemeyer BA, Lacruz RS, Lis A.
Cells. 2022 Apr 1;11(7):1190. doi: 10.3390/cells11071190.

Publications 2021

A longer isoform of Stim1 is a negative SOCE regulator but increases cAMP-modulated NFAT signaling.
Knapp ML, Alansary D, Poth V, Förderer K, Sommer F, Zimmer D, Schwarz Y, Künzel N, Kless A, Machaca K, Helms V, Mühlhaus T, Schroda M, Lis A, Niemeyer BA.
EMBO Reports. 2021 Dec 23;23(3):e53135

Blockade of PD-1 decreases neutrophilic inflammation and lung damage in experimental COPD.
Ritzmann F, Borchardt K, Vella G, Chitirala P, Angenendt A, Herr C, Menger MD, Hoth M, Lis A, Bohle RM, Bals R, Beisswenger C.
Am J Physiol Lung Cell Mol Physiol. 2021 May 1;320(5):L958-L968. doi: 10.1152/ajplung.00121.2020. Epub 2021 Mar 24. PMID: 33759577

Publications 2020

Altered Ca2+ Homeostasis in Immune Cells during Aging: Role of Ion Channels.
Zöphel D, Hof C, Lis A.
Int J Mol Sci. 2020 Dec 24;22(1):110. doi: 10.3390/ijms22010110.

Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8+ T cells of elderly mice.
Angenendt A, Steiner R, Knörck A, Schwär G, Konrad M, Krause E, Lis A.
Aging (Albany NY). 2020 Feb 12;12(4):3266-3288. doi: 10.18632/aging.102809. Epub 2020 Feb 12.

Publications 2019

IL-17C-mediated innate inflammation decreases the response to PD-1 blockade in a model of Kras-driven lung cancer.
Ritzmann F, Jungnickel C, Vella G, Kamyschnikow A, Herr C, Li D, Menger MM, Angenendt A, Hoth M, Lis A, Bals R, Beisswenger C.
Sci Rep. 2019 Jul 17;9(1):10353. doi: 10.1038/s41598-019-46759-8.

STIM-Orai Channels and Reactive Oxygen Species in the Tumor Microenvironment.
Frisch J, Angenendt A, Hoth M, Prates Roma L, Lis A.
Cancers (Basel). 2019 Mar 30;11(4). pii: E457. doi: 10.3390/cancers11040457. Review.

Publications 2018

The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins.
Suzuki S, Lis A, Schmitz C, Penner R, Fleig A.
Cell Mol Life Sci. 2018 Aug;75(16):3069-3078. doi: 10.1007/s00018-018-2786-z. Epub 2018 Mar 2. 7,014 Impact Points.

Ca2+-dependent regulation and binding of calmodulin to multiple sites of Transient Receptor Potential Melastatin 3 (TRPM3) ion channels.
Przibilla J, Dembla S, Rizun O, Lis A, Jung M, Oberwinkler J, Beck A, Philipp SE
Cell Calcium 2018 Jul;73:40-52. doi: 10.1016/j.ceca.2018.03.005. Epub 2018 Mar 31. 3,932 Impact Points.

A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity.
Zhou X, Friedmann KS, Lyrmann H, Zhou Y, Schoppmeyer R, Knörck A, Mang S, Hoxha C, Angenendt A, Backes CS, Mangerich C, Zhao R, Cappello S, Schwär G, Hässig C, Neef M, Bufe B, Zufall F, Kruse K, Niemeyer BA, Lis A, Qu B, Kummerow C, Schwarz EC, Hoth M.
J Physiol. 2018 Jan 25. doi: 10.1113/JP274964. [Epub ahead of print]

Publications 2016

A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.
Saul S, Gibhardt CS, Schmidt B, Lis A, Pasieka B, Conrad D, Jung P, Gaupp R, Wonnenberg B, Diler E, Stanisz H, Vogt T, Schwarz EC, Bischoff M, Herrmann M, Tschernig T, Kappl R, Rieger H, Niemeyer BA, Bogeski I.
Sci Signal. 2016 Mar 8;9(418):ra26.

Publications 2014

Patch-clamp measurement of ICRAC and ORAI channel activity.
Alansary D, Kilch T, Holzmann C, Peinelt C, Hoth M, Lis A.
Cold Spring Harb Protoc. 2014 Jun 2;2014(6):602-7. doi: 10.1101/pdb.top066795.

The minimal requirements to use calcium imaging to analyze ICRAC.
Alansary D, Kilch T, Holzmann C, Peinelt C, Hoth M, Lis A.
Cold Spring Harb Protoc. 2014 Jun 2;2014(6):638-42. doi: 10.1101/pdb.prot073262.

Measuring endogenous ICRAC and ORAI currents with the patch-clamp technique.
Alansary D, Kilch T, Holzmann C, Peinelt C, Hoth M, Lis A.
Cold Spring Harb Protoc. 2014 Jun 2;2014(6):630-7. doi: 10.1101/pdb.prot073254.

Publications 2013

TRPM7 is regulated by halides through its kinase domain.
Yu H, Zhang Z, Lis A, Penner R, Fleig A.
Cell Mol Life Sci. 2013 Aug;70(15):2757-71. doi: 10.1007/s00018-013-1284-6. Epub 2013 Mar 8.

STIM2 drives Ca2+ oscillations through store-operated Ca2+ entry caused by mild store depletion.
Thiel M, Lis A, Penner R.
J Physiol. 2013 Mar 15;591(6):1433-45. doi: 10.1113/jphysiol.2012.245399. Epub 2013 Jan 28.

Publications 2012

Alternative splicing of a protein domain indispensable for function of transient receptor potential melastatin 3 (TRPM3) ion channels.
Frühwald J, Camacho Londoño J, Dembla S, Mannebach S, Lis A, Drews A, Wissenbach U, Oberwinkler J, Philipp SE.
J Biol Chem. 2012 Oct 26;287(44):36663-72. doi: 10.1074/jbc.M112.396663. Epub 2012 Sep 7.

Publications 2011

Transient receptor potential melastatin 1 (TRPM1) is an ionconducting plasma membrane channel inhibited by zinc ions.
Lambert S, Drews A, Rizun O, Wagner TF, Lis A, Mannebach S, Plant S, Portz M, Meissner M, Philipp SE, Oberwinkler J.
J Biol Chem. 2011 Apr 8;286(14):12221-33. doi: 10.1074/jbc.M110.202945. Epub 2011 Jan 28.

Publications 2010

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating.
Lis A, Zierler, Peinelt C, Fleig A, Penner R.
J Gen Physiol. 2010 Dec;136(6):673-86. doi: 10.1085/jgp.201010484.

Publications 2008

Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells.
Wagner TF, Loch S, Lambert S, Straub I, Mannebach S, Mathar I, Düfer M, Lis A, Flockerzi V, Philipp SE, Oberwinkler J.
Nat Cell Biol. 2008 Dec;10(12):1421-30. doi: 10.1038/ncb1801. Epub 2008 Nov 2.

2-APB directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels.
Peinelt C, Lis A, Beck A, Fleig A, Penner R.
J Physiol. 2008 Jul 1;586(13):3061-73. doi: 10.1113/jphysiol.2008.151365. Epub 2008 Apr 10.

Publications 2007

STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC activation.
Parvez S, Beck A, Peinelt C, Soboloff J, Lis A, Monteilh-Zoller M, Gill DL, Fleig A, Penner R,
FASEB J. 2008 Mar;22(3):752-61. Epub 2007 Sep 28.

CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties.
Lis A, Peinelt C,  Beck A,  Parvez S,  Monteilh-Zoller M,  Fleig A,  Penner R.
Curr Biol. 2007 May 1;17(9):794-800. Epub 2007 Apr 19.

Publications 2006

CRACM1 multimers form the ion-selective pore of the CRAC channel.
Vig M,  Beck A,  Billingsley JM,  Lis A,  Parvez S,  Peinelt C,  Koomoa DL,  Soboloff J,  Gill DL,  Fleig A,  Kinet JP,  Penner R.
Curr Biol. 2006 Oct 24;16(20):2073-9. Epub 2006 Sep 14.

Amplification of CRAC current by STIM1 and CRACM1 (Orai1).
Peinelt C,  Vig M, Koomoa DL, Beck A, Nadler MJ, Koblan-Huberson M, Lis A, Fleig A, Penner R, Kinet JP.
Nat Cell Biol. 2006 Jul;8(7):771-3. Epub 2006 May 30.

Publications 2005

Alternative splicing switches the divalent cation selectivity of TRPM3 channels.
Oberwinkler J, Lis A, Giehl KM, Flockerzi V, Philipp SE.
J Biol Chem. 2005 Jun 10;280(23):22540-8. Epub 2005 Apr 11.

Transcriptional regulation and processing increase the functional variability of TRPM channels.
Lis A, Wissenbach U, Philipp SE.
Naunyn Schmiedebergs Arch Pharmacol. 2005 Apr;371(4):315-24. Epub 2005 Apr 27.

Modulation of Ca2+ signaling by Na+/Ca2+ exchangers in mast cells.
Aneiros E, Philipp SE, Lis A, Freichel M, Cavalie A.
J Immunol. 2005 Jan 1;174(1):119-30.