Frank Kirchhoff | Molecular Physiology




Beiersdorfer A, Wolburg H, Grawe J, Scheller A, Kirchhoff F, Lohr C (2019) Sublamina-specific organization of the blood brain barrier in the mouse olfactory nerve layer. Glia. 2020 Mar;68(3):631-645. doi: 10.1002/glia.23744. Epub 2019 Nov 7. PubMed PMID: 31696993.



Barro-Soria R, Caicedo A, Jägle H, Merkel L, Zhao N, Knop G, Gierke K, Dannullis A, Castrop H, Brandstätter JH, Kirchhoff F, Feigenspan A, Strauß O. (2019) Angiotensin-Receptor-Associated Protein Modulates Ca(2+) Signals in Photoreceptor and Mossy Fiber cells. Sci Rep. 2019 Dec 23;9(1):19622. doi: 10.1038/s41598-019-55380-8. PubMed PMID: 31873081; PubMed Central PMCID: PMC6928155

Schäfer I, Kaisler J, Scheller A, Kirchhoff F, Haghikia A, Faissner A (2019) Conditional Deletion of LRP1 Leads to Progressive Loss of Recombined NG2-Expressing Oligodendrocyte Precursor Cells in a Novel Mouse Model. Cells 30;8(12). pii: E1550. doi: 10.3390/cells8121550. PubMed PMID: 31801252; PubMed Central PMCID: PMC6953036.

Zhu JW, Zou MM, Li YF, Chen WJ, Liu JC, Chen H, Fang LP, Zhang Y, Wang ZT, Chen JB, Huang W, Li S, Jia WQ, Wang QQ, Zhen XC, Liu CF, Li S, Xiao ZC, Xu GQ, Schwamborn JC, Schachner M, Ma QH, Xu RX (2019) Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling. Cereb Cortex. 2019 Dec 11. pii: bhz306. doi: 10.1093/cercor/bhz306. PMID: 31828304

Nalbach L, Schmitt BM, Becker V, Scheller A, Laschke MW, Menger MD, Ampofo E. (2019) Nerve/glial antigen 2 is crucially involved in the revascularization of freely transplanted pancreatic islets. Cell Tissue Res 378(2):195-205. doi: 10.1007/s00441-019-03048-0. Epub 2019 May 27. PubMed PMID: 31131431

Cartarozzi LP, Perez M, Kirchhoff F, Oliveira ALR (2019) Role of MHC-I Expression on Spinal Motoneuron Survival and Glial Reactions Following Ventral Root Crush in Mice. Cells. 21;8(5). pii: E483. doi: 10.3390/cells8050483. PubMed PMID: 31117227; PubMed Central PMCID: PMC6563038.

Grundmann D, Loris E, Maas-Omlor S, Huang W, Scheller A, Kirchhoff F, Schäfer KH (2019) Enteric Glia: S100, GFAP, and Beyond. Anat Rec (Hoboken) 302(8):1333-1344. doi: 10.1002/ar.24128. Epub 2019 Apr 29. PubMed PMID: 30951262.

Beiersdorfer A, Scheller A, Kirchhoff F, Lohr C (2019) Panglial gap junctions between astrocytes and olfactory ensheathing cells mediate transmission of Ca(2+) transients and neurovascular coupling. Glia 67(7):1385-1400. doi: 10.1002/glia.23613. Epub 2019 Mar 18. PubMed PMID: 30883940.

Huang W, Guo Q, Bai X, Scheller A, Kirchhoff F (2019) Early embryonic NG2 glia are exclusively gliogenic and do not generate neurons in the brain. Glia 67(6):1094-1103. doi: 10.1002/glia.23590. Epub 2019 Feb 6. PubMed PMID: 30724411.



Petrelli F, Dallérac G, Pucci L, Calì C, Zehnder T, Sultan S, Lecca S, Chicca A, Ivanov A, Asensio CS, Gundersen V, Toni N, Knott GW, Magara F, Gertsch J, Kirchhoff F, Déglon N, Giros B, Edwards RH, Mothet JP, Bezzi P. (2018) Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments. Mol Psychiatry. Aug 20. doi: 10.1038/s41380-018-0226-y. [Epub ahead of print] PMID: 30127471

Katz E, Stoler O, Scheller A, Khrapunsky Y, Goebbels S, Kirchhoff F, Gutnick MJ, Wolf F, Fleidervish IA (2018) Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons. Proc Natl Acad Sci U S A. 115: E7184-E7192. doi: 10.1073/pnas.1720493115. Epub 2018 Jul 10. PMID: 29991598

Stopper L, Bălşeanu TA, Cătălin B, Rogoveanu OC, Mogoantă L, Scheller A (2018) Microglia morphology in the physiological and diseased brain - from fixed tissue to in vivo conditions. Rom J Morphol Embryol. 2018;59(1):7-12. PMID: 29940606

Huang W, Bai X, Stopper L, Catalin B, Cartarozzi LP, Scheller A, Kirchhoff F (2018) During Development NG2 Glial Cells of the Spinal Cord are Restricted to the Oligodendrocyte Lineage, but Generate Astrocytes upon Acute Injury. Neuroscience. 18;385:154-165. doi: 10.1016/j.neuroscience.2018.06.015. PMID: 29913244

Barros LF, Bolaños JP, Bonvento G, Bouzier-Sore AK, Brown A, Hirrlinger J, Kasparov S, Kirchhoff F, Murphy AN, Pellerin L, Robinson MB, Weber B (2018) Current technical approaches to brain energy metabolism. Glia. 2018 Jun;66(6):1138-1159. doi: 10.1002/glia.23248. Epub 2017 Nov 7. Review. PMID: 29110344

Schmitt BM, Laschke MW, Rössler OG, Huang W, Scheller A, Menger MD, Ampofo E (2018) Nerve/glial antigen (NG) 2 is a crucial regulator of intercellular adhesion molecule (ICAM)-1 expression. Biochim Biophys Acta. 2018 Jan;1865(1):57-66. doi: 10.1016/j.bbamcr.2017.09.019. Epub 2017 Sep 28. PMID: 28964848 [PubMed - indexed for MEDLINE]

Jahn HM, Kasakow CV, Helfer A, Michely J, Verkhratsky A, Maurer HH, Scheller A and Kirchhoff F (2018) Refined protocols of tamoxifen injection for inducible DNA recombination in mouse astroglia. Scientific Reports 8, 5913. doi: 10.1038/s41598-018-24085-9. PMID: 29651133

Cartarozzi LP, Rieder P, Bai X, Scheller A, Oliveira ALR, Kirchhoff F (2018) In vivo two-photon imaging of motoneurons and adjacent glia in the ventral spinal cord. J Neurosci Methods. 299:8-15. doi: 10.1016/j.jneumeth.2018.01.005. PMID: 29408351



Wu ZQ, Li D, Huang Y, Chen XP, Huang W, Liu CF, Zhao HQ, Xu RX, Cheng M, Schachner M, Ma QH (2017) Caspr Controls the Temporal Specification of Neural Progenitor Cells through Notch Signaling in the Developing Mouse Cerebral Cortex. Cereb Cortex 27 1369-1385. PMID: 26740489

Hofmann K, Rodriguez-Rodriguez R, Gaebler A, Casals N, Scheller A, Kuerschner L (2017) Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids. Sci Rep-UK 7 10779. PMID: 28883484

Hofmann K, Lamberz C, Piotrowitz K, Offermann N, But D, Scheller A, Al-Amoudi A, Kuerschner L (2017) Tanycytes and a differential fatty acid metabolism in the hypothalamus. Glia 65 231-249. PMID: 27726181

Cătălin B, Stopper L, Bălşeanu TA, Scheller A (2017) The in situ morphology of microglia is highly sensitive to the mode of tissue fixation. J Chem Neuroanat 86 59-66. PMID: 28866082

Schwarz Y, Zhao N, Kirchhoff F, Bruns D (2017) Astrocytes control synaptic strength by two distinct v-SNARE-dependent release pathways. Nature neuroscience 20 (11):1529-1539. doi:10.1038/nn.4647. PMID: 28945220

Kirchhoff F (2017) Analysis of Functional NMDA Receptors in Astrocytes. Methods in molecular biology 1677:241-251. doi:10.1007/978-1-4939-7321-7_13. PMID: 28986877

Scheller A, Bai X, Kirchhoff F (2017) The Role of the Oligodendrocyte Lineage in Acute Brain Trauma. Neurochemical research 42 (9):2479-2489. doi:10.1007/s11064-017-2343-4. PMID: 28702713

Belkacemi T, Niermann A, Hofmann L, Wissenbach U, Birnbaumer L, Leidinger P, Backes C, Meese E, Keller A, Bai X, Scheller A, Kirchhoff F, Philipp SE, Weissgerber P, Flockerzi V, Beck A (2017) TRPC1- and TRPC3-dependent Ca(2+) signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo. Glia 65 (9):1535-1549. doi:10.1002/glia.23180. PMID: 28636132

Rollmann MF, Herath SC, Kirchhoff F, Braun BJ, Holstein JH, Pohlemann T, Menger MD, Histing T )2017) Pelvic ring fractures in the elderly now and then – a pelvic registry study. Arch Gerontol Geriatr 71:83-88. doi:                10.1016/j.archger.2017.03.007. Epub 2017 Mar 19. PubMed PMID: 28384504.

Berl S, Karram K, Scheller A, Jungblut M, Kirchhoff F, Waisman A (2017) Enrichment and isolation of neurons from adult mouse brain for ex vivo analysis. Journal of neuroscience methods 283:15-22. doi:10.1016/j.jneumeth.2017.03.015. PMID: 28336359



Schneider S, Gruart A, Grade S, Zhang Y, Kröger S, Kirchhoff F, Eichele G, Delgado García JM, Dimou L. Decrease in newly generated oligodendrocytes leads to motor dysfunctions and changed myelin structures that can be rescued by transplanted cells. Glia. 2016 Sep 12. doi: 10.1002/glia.23055. [Epub ahead of print] PMID: 27615452

Grundmann D, Markwart F, Scheller A, Kirchhoff F, Schäfer KH (2016) Phenotype and distribution pattern of nestin-GFP-expressing cells in murine myenteric plexus. Cell Tissue Res. 2016 Aug 13. [Epub ahead of print] PMID: 27519533

Schweigmann M, Kirchhoff F, Koch KP (2016) Modeling and Simulations in Time Domain of a Stimulation Set-up for Cortical Applications. Eur J Transl Myol. 2016 Jun 13;26(2):6017. doi: 10.4081/ejtm.2016.6017. eCollection 2016 Jun 13. PMID: 27478564

Scheller A, Kirchhoff F (2016) Endocannabinoids and Heterogeneity of Glial Cells in Brain Function. Front Integr Neurosci. 2016 Jul 5;10:24. doi: 10.3389/fnint.2016.00024. eCollection 2016. No abstract available. PMID: 27458351

Saab AS, Tzvetavona ID, Trevisiol A, Baltan S, Dibaj P, Kusch K, Möbius W, Goetze B, Jahn HM, Huang W, Steffens H, Schomburg ED, Pérez-Samartín A, Pérez-Cerdá F, Bakhtiari D, Matute C, Löwel S, Griesinger C, Hirrlinger J, Kirchhoff F, Nave KA (2016) Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism. Neuron. 2016 Jul 6;91(1):119-32. doi: 10.1016/j.neuron.2016.05.016. Epub 2016 Jun 9. PMID: 27292539

Rudolph R, Jahn HM, Courjaret R, Messemer N, Kirchhoff F, Deitmer JW (2016) The inhibitory input to mouse cerebellar Purkinje cells is reciprocally modulated by Bergmann glial P2Y1 and AMPA receptor signaling. Glia. 2016 Jul;64(7):1265-80. doi: 10.1002/glia.22999. Epub 2016 May 4. PMID: 27144942

Resende FF, Bai X, Del Bel EA, Kirchhoff F, Scheller A, Titze-de-Almeida R (2016) Evaluation of TgH(CX3CR1-EGFP) mice implanted with mCherry-GL261 cells as an in vivo model for morphometrical analysis of glioma-microglia interaction. BMC Cancer. 2016 Feb 8;16:72. doi: 10.1186/s12885-016-2118-3. PMID: 26856327



Schnell C, Negm M, Driehaus J, Scheller A, Hülsmann S (2015) Norepinephrine-induced calcium signaling in astrocytes in the respiratory network of the ventrolateral medulla. Respir Physiol Neurobiol. pii: S1569-9048(15)30062-8. doi: 10.1016/j.resp.2015.10.008. [Epub ahead of print] PMID: 26514085

Tristão FS, Lazzarini M, Martin S, Amar M, Stühmer W, Kirchhoff F, Gomes LA, Lanfumey L, Prediger RD, Sepulveda JE, Del-Bel EA, Raisman-Vozari R. (2015) CX3CR1 Disruption Differentially Influences Dopaminergic Neuron Degeneration in Parkinsonian Mice Depending on the Neurotoxin and Route of Administration. Neurotox Res. Sep 24. [Epub ahead of print] PMID: 26403659

Jahn HM, Scheller A, Kirchhoff F. (2015) Genetic control of astrocyte function in neural circuits. Front Cell Neurosci 9:310. doi: 10.3389/fncel.2015.00310. PMID: 26347607



Scheller A, Vivien D, Kirchhoff F, Orset C, Sandu RE, Popa-Wagner A. (2014) Imaging neuroinflammation after brain injuries by ultrasensitive MRI and two-photon laser-scanning microscopy. Rom J Morphol Embryol 55(3):735-43. PMID: 25329099

Cupido A, Catalin B, Steffens H, Kirchhoff F (2014) Surgical procedures to study microglial motility in the brain and in the spinal cord by in vivo two-photon laser-scanning microcopy. In: Laser Scanning Microscopy and Quantitative Image Analysis of Neuronal Tissue. Springer Protocols – Neuromethods. Humana Press.

Huang W, Zhao N, Bai X, Karram K, Trotter J, Goebbels S, Scheller A, Kirchhoff F (2014) Novel NG2-CreERT2 knock-in mice demonstrate heterogeneous differentiation potential of NG2 glia during devel-opment. Glia. Doi: 10.1002/glia.22648. [Epub ahead of print] PMID: 24578301



Cătălin B, Cupido A, Iancău M, Albu CV, Kirchhoff F (2013) Microglia: first responders in the central nervous system. Rom J Morphol Embryol. 2013;54(3):467-72. PMID: 24068392

Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, Kirchhoff F, Möbius W, Goebbels S, Nave KA, Schneider A, Simons M, Klugmann M, Trotter J, Krämer-Albers EM (2013) Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol 11:e1001604. doi: 10.1371/journal.pbio.1001604. PMID: 23874151

Bai X, Saab AS, Huang W, Hoberg IK, Kirchhoff F, Scheller A (2013) Genetic Background Affects Human Glial Fibrillary Acidic Protein Promoter Activity. PLoS ONE. 10.1371/journal.pone.0066873. PMID: 23826164

Semar S, Klotz M, Letiembre M, Van Ginneken C, Braun A, Jost V, Bischof M, Lammers WJ, Liu Y, Fassbender K, Wyss-Coray T, Kirchhoff F, Schäfer KH. (2013) Changes of the Enteric Nervous System in Amyloid-β Protein Precursor Transgenic Mice Correlate with Disease Progression. J Alzheimers Dis. 36:7-20. doi: 10.3233/JAD-120511. PMID: 23531500

Kettenmann H, Kirchhoff F, Verkhratsky A (2013) Microglia: new roles for the synaptic stripper. Neuron 9:10-8. PMID: 23312512

Puschmann TB, Zandén C, De Pablo Y, Kirchhoff F, Pekna M, Liu J, Pekny M (2013) Bioactive 3D cell culture system minimizes cellular stress and maintains the in vivo-like morphological complexity of astroglial cells. Glia 61:432-40. PMID: 23292921



Kirchhoff F (2012) Role of Microglia in the normal brain. In: Neuroglia. 3rd ed. Oxford University Press, New York. Eds. Kettenmann H and Ransom BR, pp 605-613

Steffens H, Nadrigny F, Kirchhoff F. (2012) In vivo two-photon imaging of neurons and glia in the mouse spinal cord. Cold Spring Harb Protoc. 2012 Dec 1 (12). doi:pii: pdb.prot072264. 10.1101/pdb.prot072264. PMID: 23209139

Steffens H, Nadrigny F, Kirchhoff F. (2012) Preparation of the mouse spinal column for repetitive imaging using two-photon laser-scanning microscopy. Cold Spring Harb Protoc. 2012 Dec 1 (12). doi:pii: pdb.prot072256. 10.1101/pdb.prot072256. PMID: 23209138

Steffens H, Nadrigny F, Kirchhoff F. (2012) Preparation of the mouse spinal column for single imaging using two-photon laser-scanning microscopy. Cold Spring Harb Protoc. 2012 Dec 1 (12). doi:pii: pdb.prot072249. 10.1101/pdb.prot072249. PMID: 23209137

Kirchhoff F, Debarbieux F, Kronland-Martinet C, Cojocaru GR, Popa-Wagner A. (2012) Combined two-photon laser-scanning microscopy and spectral microCT X-ray imaging to characterize the cellular signature and evolution of microstroke foci. Rom J Morphol Embryol. 53: 671-5. PMID: 23188424

Dibaj P, Zschüntzsch J, Steffens H, Scheffel J, Göricke B, Weishaupt JH, Le Meur K, Kirchhoff F, Hanisch UK, Schomburg ED, Neusch C. (2012) Influence of Methylene Blue on Microglia-Induced Inflammation and Motor Neuron Degeneration in the SOD1(G93A) Model for ALS. PLoS One 7:e43963. PMID: 22952827

Saab AS, Neumeyer A, Jahn HM, Cupido A, Šimek AA, Boele HJ, Scheller A, Le Meur K, Götz M, Monyer H, Sprengel R, Rubio ME, Deitmer JW, De Zeeuw CI, Kirchhoff F. (2012) Bergmann glial AMPA receptors are required for fine motor coordination. Science 337:749-53. PMID: 22767895

Tchorz JS, Tome M, Cloëtta D, Sivasankaran B, Grzmil M, Huber RM, Rutz-Schatzmann F, Kirchhoff F, Schaeren-Wiemers N, Gassmann M, Hemmings BA, Merlo A, Bettler B (2012) Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry. Cell Death Dis. 3:e325. PMID: 22717580

Ertürk A, Mauch CP, Hellal F, Förstner F, Keck T, Becker K, Jährling N, Steffens H, Richter M, Hübener M, Kramer E, Kirchhoff F, Dodt HU, Bradke F (2012) Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury. Nat Medicine. 18:166-71. PMID: 22198277

Guo J, Niu R, Huang W, Zhou M, Shi J, Zhang L, Liao H. (2012) Growth factors from tumor microenvironment possibly promote the proliferation of glioblastoma-derived stem-like cells in vitro. Pathol Oncol Res. 18: 1047-57. PMID: 22996727

Vinueza Veloz MF, Buijsen RA, Willemsen R, Cupido A, Bosman LW, Koekkoek SK, Potters JW, Oostra BA, De Zeeuw CI. (2012) The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice. Genes Brain Behav. 11: 325-31. PMID: 22257369



Steffens H, Nadrigny F and Kirchhoff F (2011) Two-Photon Imaging of Neurons and Glia in the Spinal Cord In Vivo. Imaging in Neuroscience: A Laboratory Manual. pp. 715-727. Cold Spring Harbor Laboratory.

Lioy DT, Garg SK, Monaghan CE, Raber J, Foust KD, Kaspar BK, Hirrlinger PG, Kirchhoff F, Bissonnette JM, Ballas N, Mandel G (2011) A role for glia in the progression of Rett's syndrome. Nature 475: 497-500. PMID: 21716289

Herzog E, Nadrigny F, Silm K, Biesemann C, Helling I, Bersot T, Steffens H, Schwartzmann R, Nägerl UV, El Mestikawy S, Rhee J, Kirchhoff F, Brose N (2011) In vivo imaging of intersynaptic vesicle exchange using VGLUT1 Venus knock-in mice. J Neurosci. 31:15544-59. PMID: 22031900

Dibaj P, Steffens H, Zschüntzsch J, Kirchhoff F, Schomburg ED, Neusch C (2011) In vivo imaging reveals rapid morphological reactions of astrocytes towards focal lesions in an ALS mouse model. Neurosci Lett. 497:148-51. PMID: 21539893

Dibaj P, Steffens H, Zschuntzsch J, Nadrigny F, Schomburg ED, Kirchhoff F, Neusch C (2011) In Vivo Imaging Reveals Distinct Inflammatory Activity of CNS Microglia versus PNS Macrophages in a Mouse Model for ALS. Plos One 6:e17910. PMID: 21437247

Perez-Cruz C, Nolte MW, van Gaalen MM, Rustay NR, Termont A, Tanghe A, Kirchhoff F, Ebert U (2011) Reduced Spine Density in Specific Regions of CA1 Pyramidal Neurons in Two Transgenic Mouse Models of Alzheimer's Disease. J Neurosci 31:3926-3934. PMID: 21389247

Dibaj P, Steffens H, Nadrigny F, Kirchhoff F, Schomburg ED (2011) Purinergic activation of dorsal root ganglion neurones in vivo. Neurosci Lett 487:107-109. PMID: 20937358



Reyes-Haro D, Müller J, Boresch M, Pivneva T, Benedetti B, Scheller A, Nolte C, Kettenmann H. (2010) Neuron-astrocyte interactions in the medial nucleus of the trapezoid body. J Gen Physiol. Jun;135: 583-94. PMID: 20479112

Beckervordersandforth R, Tripathi P, Ninkovic J, Bayam E, Lepier A, Stempfhuber B, Kirchhoff F, Hirrlinger J, Haslinger A, Lie DC, Beckers J, Yoder B, Irmler M, Gotz M (2010) In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells. Cell Stem Cell 7:744-758. PMID: 21112568

Dibaj P, Steffens H, Nadrigny F, Neusch C, Kirchhoff F, Schomburg ED (2010) Long-lasting post-mortem activity of spinal microglia in situ in mice. J Neurosci Res 88:2431-2440. PMID: 20623536

Dibaj P, Nadrigny F, Steffens H, Scheller A, Hirrlinger J, Schomburg ED, Neusch C, Kirchhoff F (2010) NO mediates microglial response to acute spinal cord injury under ATP control in vivo. Glia 58:1133-1144. PMID: 20468054

Heneka MT, Nadrigny F, Regen T, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch UK, Kummer MP (2010) Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine. Proc Natl Acad Sci U S A 107:6058-6063. PMID: 20231476

Kirchhoff F (2010) Questionable Calcium. Science 327:1212-1213. PMID: 20203041

Reichenbach A, Derouiche A, Kirchhoff F (2010) Morphology and dynamics of perisynaptic glia. Brain Res Rev 63:11-25. PMID: 20176054



Hirrlinger J, Scheller A, Hirrlinger PG, Kellert B, Tang W, Wehr MC, Goebbels S, Reichenbach A, Sprengel R, Rossner MJ, Kirchhoff F (2009) Split-cre complementation indicates coincident activity of different genes in vivo. Plos One 4:e4286. PMID: 19172189

Neher RA, Mitkovski M, Kirchhoff F, Neher E, Theis FJ, Zeug A (2009) Blind source separation techniques for the decomposition of multiply labeled fluorescence images. Biophys J 96:3791-3800. PMID: 19413985

Ylera B, Erturk A, Hellal F, Nadrigny F, Hurtado A, Tahirovic S, Oudega M, Kirchhoff F, Bradke F (2009) Chronically CNS-injured adult sensory neurons gain regenerative competence upon a lesion of their peripheral axon. Curr Biol 19:930-936. PMID: 19409789



Dimou L, Simon C, Kirchhoff F, Takebayashi H, Gotz M (2008) Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex. J Neurosci 28:10434-10442. PMID: 18842903

Hamilton N, Vayro S, Kirchhoff F, Verkhratsky A, Robbins J, Gorecki DC, Butt AM (2008) Mechanisms of ATP- and glutamate-mediated calcium signaling in white matter astrocytes. Glia 56:734-749. PMID: 18293404

Lalo U, Pankratov Y, Wichert SP, Rossner MJ, North RA, Kirchhoff F, Verkhratsky A (2008) P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes. J Neurosci 28:5473-5480. PMID: 18495881

Wolf F, Kirchhoff F (2008) Neuroscience. Imaging astrocyte activity. Science 320:1597-1599. PMID: 18566273



Chvatal A, Anderova M, Hock M, Prajerova I, Neprasova H, Chvatal V, Kirchhoff F, Sykova E (2007) Three-dimensional confocal morphometry reveals structural changes in astrocyte morphology in situ. J Neurosci Res 85:260-271. PMID: 17086549

Chvatal A, Anderova M, Kirchhoff F (2007) Three-dimensional confocal morphometry - a new approach for studying dynamic changes in cell morphology in brain slices. J Anat 210:671-683. PMID: 17488344

Dibaj P, Kaiser M, Hirrlinger J, Kirchhoff F, Neusch C (2007) Kir4.1 channels regulate swelling of astroglial processes in experimental spinal cord edema. J Neurochem 103:2620-8. PMID: 17953658

Giaume C, Kirchhoff F, Matute C, Reichenbach A, Verkhratsky A (2007) Glia: the fulcrum of brain diseases. Cell Death Differ 14:1324-1335.  PMID: 17431421

Nadrigny F, Li D, Kemnitz K, Ropert N, Koulakoff A, Rudolph S, Vitali M, Giaume C, Kirchhoff F, Oheim M (2007) Systematic colocalization errors between acridine orange and EGFP in astrocyte vesicular organelles. Biophys J 93:969-980. PMID: 17416619

Oertel J, Villmann C, Kettenmann H, Kirchhoff F, Becker CM (2007) A novel glycine receptor beta subunit splice variant predicts an unorthodox transmembrane topology. Assembly into heteromeric receptor complexes. J Biol Chem 282:2798-2807. PMID: 17145751

Verkhratsky A, Kirchhoff F (2007) Glutamate-mediated neuronal-glial transmission. J Anat 210:651-660. PMID: 17504269

Verkhratsky A, Kirchhoff F (2007) NMDA Receptors in glia. Neuroscientist 13:28-37. PMID: 17229973

Wigley R, Hamilton N, Nishiyama A, Kirchhoff F, Butt AM (2007) Morphological and physiological interactions of NG2-glia with astrocytes and neurons. J Anat 210:661-670. PMID: 17459143

Winter SM, Hirrlinger J, Kirchhoff F, Hulsmann S (2007) Transgenic expression of fluorescent proteins in respiratory neurons. Respir Physiol Neurobiol 159:108-114. PMID: 17616445

Wu Q, Butzkueven H, Gresle M, Kirchhoff F, Friedhuber A, Yang Q, Wang H, Fang K, Lei H, Egan GF, Kilpatrick TJ (2007) MR diffusion changes correlate with ultra-structurally defined axonal degeneration in murine optic nerve. Neuroimage 37:1138-1147. PMID: 17689104



Faure J, Lachenal G, Court M, Hirrlinger J, Chatellard-Causse C, Blot B, Grange J, Schoehn G, Goldberg Y, Boyer V, Kirchhoff F, Raposo G, Garin J, Sadoul R (2006) Exosomes are released by cultured cortical neurones. Mol Cell Neurosci 31:642-648. PMID: 16446100

Hirrlinger PG, Scheller A, Braun C, Hirrlinger J, Kirchhoff F (2006) Temporal control of gene recombination in astrocytes by transgenic expression of the tamoxifen-inducible DNA recombinase variant CreERT2. Glia 54:11-20. PMID: 16575885

Houades V, Rouach N, Ezan P, Kirchhoff F, Koulakoff A, Giaume C (2006) Shapes of astrocyte networks in the juvenile brain. Neuron Glia Biol 2:3-14. PMID: 18634587

Kaiser M, Maletzki I, Hulsmann S, Holtmann B, Schulz-Schaeffer W, Kirchhoff F, Bahr M, Neusch C (2006) Progressive loss of a glial potassium channel (KCNJ10) in the spinal cord of the SOD1 (G93A) transgenic mouse model of amyotrophic lateral sclerosis. J Neurochem 99:900-912. PMID: 16925593

Lalo U, Pankratov Y, Kirchhoff F, North RA, Verkhratsky A (2006) NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes. J Neurosci 26:2673-2683. PMID: 16525046

Lu YB, Franze K, Seifert G, Steinhauser C, Kirchhoff F, Wolburg H, Guck J, Janmey P, Wei EQ, Kas J, Reichenbach A (2006) Viscoelastic properties of individual glial cells and neurons in the CNS. Proc Natl Acad Sci U S A 103:17759-17764. PMID: 17093050

Nadrigny F, Rivals I, Hirrlinger PG, Koulakoff A, Personnaz L, Vernet M, Allioux M, Chaumeil M, Ropert N, Giaume C, Kirchhoff F, Oheim M (2006) Detecting fluorescent protein expression and co-localisation on single secretory vesicles with linear spectral unmixing. Eur Biophys J 35:533-547. PMID: 16568270

Neusch C, Papadopoulos N, Muller M, Maletzki I, Winter SM, Hirrlinger J, Handschuh M, Bahr M, Richter DW, Kirchhoff F, Hulsmann S (2006) Lack of the Kir4.1 channel subunit abolishes K+ buffering properties of astrocytes in the ventral respiratory group: impact on extracellular K+ regulation. J Neurophysiol 95:1843-1852. PMID: 16306174

Oheim M, Kirchhoff F, Stuhmer W (2006) Calcium microdomains in regulated exocytosis. Cell Calcium 40:423-439. PMID: 17067670



Hirrlinger J, Moeller H, Kirchhoff F, Dringen R (2005) Expression of multidrug resistance proteins (Mrps) in astrocytes of the mouse brain: a single cell RT-PCR study. Neurochem Res 30:1237-1244. PMID: 16341585

Hirrlinger PG, Scheller A, Braun C, Quintela-Schneider M, Fuss B, Hirrlinger J, Kirchhoff F (2005) Expression of reef coral fluorescent proteins in the central nervous system of transgenic mice. Mol Cell Neurosci 30:291-303. PMID: 16169246

Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314-1318. PMID: 15831717



Grass D, Pawlowski PG, Hirrlinger J, Papadopoulos N, Richter DW, Kirchhoff F, Hulsmann S (2004) Diversity of functional astroglial properties in the respiratory network. J Neurosci 24:1358-1365. PMID: 14960607

Hirrlinger J, Hulsmann S, Kirchhoff F (2004) Astroglial processes show spontaneous motility at active synaptic terminals in situ. Eur J Neurosci 20:2235-2239. PMID: 15450103

Nimmerjahn A, Kirchhoff F, Kerr JN, Helmchen F (2004) Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo. Nat Methods 1:31-37. PMID: 14782150



Huttmann K, Sadgrove M, Wallraff A, Hinterkeuser S, Kirchhoff F, Steinhauser C, Gray WP (2003) Seizures preferentially stimulate proliferation of radial glia-like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis. Eur J Neurosci 18:2769-2778. PMID: 14656326

Malatesta P, Hack MA, Hartfuss E, Kettenmann H, Klinkert W, Kirchhoff F, Gotz M (2003) Neuronal or glial progeny: regional differences in radial glia fate. Neuron 37:751-764. PMID: 12628166

Matthias K, Kirchhoff F, Seifert G, Huttmann K, Matyash M, Kettenmann H, Steinhauser C (2003) Segregated expression of AMPA-type glutamate receptors and glutamate transporters defines distinct astrocyte populations in the mouse hippocampus. J Neurosci 23:1750-1758. PMID: 12629179

Wehner T, Bontert M, Eyupoglu I, Prass K, Prinz M, Klett FF, Heinze M, Bechmann I, Nitsch R, Kirchhoff F, Kettenmann H, Dirnagl U, Priller J (2003) Bone marrow-derived cells expressing green fluorescent protein under the control of the glial fibrillary acidic protein promoter do not differentiate into astrocytes in vitro and in vivo. J Neurosci 23:5004-5011. PMID: 12832523



Schipke CG, Boucsein C, Ohlemeyer C, Kirchhoff F, Kettenmann H (2002) Astrocyte Ca2+ waves trigger responses in microglial cells in brain slices. FASEB J 16:255-257. PMID: 11772946



Diers-Fenger M, Kirchhoff F, Kettenmann H, Levine JM, Trotter J (2001) AN2/NG2 protein-expressing glial progenitor cells in the murine CNS: isolation, differentiation, and association with radial glia. Glia 34:213-228. PMID: 11329183

Kirchhoff F, Dringen R, Giaume C (2001) Pathways of neuron-astrocyte interactions and their possible role in neuroprotection. Eur Arch Psychiatry Clin Neurosci 251:159-169. PMID: 11692580

Nolte C, Matyash M, Pivneva T, Schipke CG, Ohlemeyer C, Hanisch UK, Kirchhoff F, Kettenmann H (2001) GFAP promoter-controlled EGFP-expressing transgenic mice: a tool to visualize astrocytes and astrogliosis in living brain tissue. Glia 33:72-86. PMID: 11169793

Schipke CG, Ohlemeyer C, Matyash M, Nolte C, Kettenmann H, Kirchhoff F (2001) Astrocytes of the mouse neocortex express functional N-methyl-D-aspartate receptors. FASEB J 15:1270-1272. PMID: 11344110

Synowitz M, Ahmann P, Matyash M, Kuhn SA, Hofmann B, Zimmer C, Kirchhoff F, Kiwit JC, Kettenmann H (2001) GABA(A)-receptor expression in glioma cells is triggered by contact with neuronal cells. Eur J Neurosci 14:1294-1302. PMID: 11703458



Fuss B, Mallon B, Phan T, Ohlemeyer C, Kirchhoff F, Nishiyama A, Macklin WB (2000) Purification and analysis of in vivo-differentiated oligodendrocytes expressing the green fluorescent protein. Dev Biol 218:259-274. PMID: 10656768



Condorelli DF, Conti F, Gallo V, Kirchhoff F, Seifert G, Steinhauser C, Verkhratsky A, Yuan X (1999) Expression and functional analysis of glutamate receptors in glial cells. Adv Exp Med Biol 468:49-67. PMID: 10635019

Kirischuk S, Kirchhoff F, Matyash V, Kettenmann H, Verkhratsky A (1999) Glutamate-triggered calcium signalling in mouse bergmann glial cells in situ: role of inositol-1,4,5-trisphosphate-mediated intracellular calcium release. Neuroscience 92:1051-1059. PMID: 10426545

Schmidt K, Eulitz D, Veh RW, Kettenmann H, Kirchhoff F (1999) Heterogeneous expression of voltage-gated potassium channels of the shaker family (Kv1) in oligodendrocyte progenitors. Brain Res 843:145-160. PMID: 10528121



Prinz M, Hanisch UK, Kettenmann H, Kirchhoff F (1998) Alternative splicing of mouse IL-15 is due to the use of an internal splice site in exon 5. Brain Res Mol Brain Res 63:155-162. PMID: 9838089

Schmidt-Ott KM, Tuschick S, Kirchhoff F, Verkhratsky A, Liefeldt L, Kettenmann H, Paul M (1998) Single-cell characterization of endothelin system gene expression in the cerebellum in situ. J Cardiovasc Pharmacol 31 Suppl 1:S364-S366. PMID: 9595483



Hanisch UK, Lyons SA, Prinz M, Nolte C, Weber JR, Kettenmann H, Kirchhoff F (1997) Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity. J Biol Chem 272:28853-28860. PMID: 9360952

Kirchhoff F, Ohlemeyer C, Kettenmann H (1997) Expression of myelin-associated glycoprotein transcripts in murine oligodendrocytes. Neuroscience 78:561-570. PMID: 9145810

Moller T, Kann O, Prinz M, Kirchhoff F, Verkhratsky A, Kettenmann H (1997) Endothelin-induced calcium signaling in cultured mouse microglial cells is mediated through ETB receptors. Neuroreport 8:2127-2131. PMID: 9243597

Nolte C, Kirchhoff F, Kettenmann H (1997) Epidermal growth factor is a motility factor for microglial cells in vitro: evidence for EGF receptor expression. Eur J Neurosci 9:1690-1698. PMID: 9283823

Terness P, Welschof M, Moldenhauer G, Jung M, Moroder L, Kirchhoff F, Kipriyanov S, Little M, Opelz G (1997) Idiotypic vaccine for treatment of human B-cell lymphoma. Construction of IgG variable regions from single malignant B cells. Hum Immunol 56:17-27. PMID: 9455490

Tuschick S, Kirischuk S, Kirchhoff F, Liefeldt L, Paul M, Verkhratsky A, Kettenmann H (1997) Bergmann glial cells in situ express endothelinB receptors linked to cytoplasmic calcium signals. Cell Calcium 21:409-419. PMID: 9223677



Kirchhoff F, Mulhardt C, Pastor A, Becker CM, Kettenmann H (1996) Expression of glycine receptor subunits in glial cells of the rat spinal cord. J Neurochem 66:1383-1390. PMID: 8627289



Jabs R, Kirchhoff F, Kettenmann H, Steinhauser C (1994) Kainate activates Ca(2+)-permeable glutamate receptors and blocks voltage-gated K+ currents in glial cells of mouse hippocampal slices. Pflugers Arch 426:310-319. PMID: 8183642



Fahrig T, Probstmeier R, Spiess E, Meyer-Franke A, Kirchhoff F, Drescher B, Schachner M (1993) Functional topography of the myelin-associated glycoprotein. I. Mapping of domains by electron microscopy. Eur J Neurosci 5:1118-1126. PMID: 7506618

Gimpl G, Kirchhoff F, Lang RE, Kettenmann H (1993) Identification of neuropeptide Y receptors in cultured astrocytes from neonatal rat brain. J Neurosci Res 34:198-205. PMID: 8450563

Kirchhoff F, Hofer HW, Schachner M (1993) Myelin-associated glycoprotein is phosphorylated by protein kinase C. J Neurosci Res 36:368-381. PMID: 7505837



Kirchhoff F, Ohlemeyer C, Kettenmann H (1992) A fast perfusion system for single cell physiology optimized for microscopes with water immersion objectives. Pflugers Arch 420:573-577. PMID: 1614832

Kirchhoff F, Kettenmann H (1992) GABA Triggers a [Ca2+]i Increase in Murine Precursor Cells of the Oligodendrocyte Lineage. Eur J Neurosci 4:1049-1058. PMID: 12106410



Schneider-Schaulies J, Kirchhoff F, Archelos J, Schachner M (1991) Down-regulation of myelin-associated glycoprotein on Schwann cells by interferon-gamma and tumor necrosis factor-alpha affects neurite outgrowth. Neuron 7:995-1005. PMID: 1722413



Bartsch U, Kirchhoff F, Schachner M (1990) Highly sialylated N-CAM is expressed in adult mouse optic nerve and retina. J Neurocytol 19:550-565. PMID: 2243247



Bartsch U, Kirchhoff F, Schachner M (1989) Immunohistological localization of the adhesion molecules L1, N-CAM, and MAG in the developing and adult optic nerve of mice. J Comp Neurol 284:451-462. PMID: 2474006

Sadoul R, Kirchhoff F, Schachner M (1989) A protein kinase activity is associated with and specifically phosphorylates the neural cell adhesion molecule L1. J Neurochem 53:1471-1478. PMID: 2677246

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