Publications

Schwarz Y, Oleinikov K, Schindeldecker B, Wyatt A, Weißgerber P, Flockerzi V, Boehm U, Freichel M, Bruns D.
TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses.
PLoS Biol. 2019,17(9). doi

Tian Q, Schröder L, Schwarz Y, Flockerzi A, Kaestner L, Zeug A, Bruns D, Lipp P.
Large scale, unbiased analysis of elementary calcium signaling events in cardiac myocytes.
J Mol Cell Cardiol. 2019, 135, 79-89. doi

Shaaban A, Dhara M, Frisch W, Harb A, Shaib AH, Becherer U, Bruns D, Mohrmann R.
The SNAP-25 linker supports fusion intermediates by local lipid interactions.
Elife. 2019; 8. doi

Makke M, Mantero Martinez M, Gaya S, Schwarz Y, Frisch W, Silva-Bermudez L, Jung M, Mohrmann R, Dhara M, Bruns D.
A mechanism for exocytotic arrest by the Complexin C-terminus.
Elife. 2018, 7, 38981. doi

Dhara M, Mohrmann R, Bruns D.
v-SNARE function in chromaffin cells.
Pflugers Arch. 2018, 470, 169-180. doi

Schwarz Y, Zhao N, Kirchhoff F, Bruns D.
Astrocytes control synaptic strength by two distinct v-SNARE-dependent release pathways.
Nat Neurosci. 2017. 20, 1529-1539, see Faculty of 1000. doi

Bröker-Lai J, Kollewe A, Schindeldecker B, Pohle J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weißgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Köhr G, Fakler B, Flockerzi V, Bruns D, Freichel M.
Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory.
EMBO J. 2017, 36, 2770-2789. doi

Bost A, Shaib AH, Schwarz Y, Niemeyer BA, Becherer U.
Large dense-core vesicle exocytosis from mouse dorsal root ganglion neurons is regulated by neuropeptide Y.
Neuroscience. 2017, 346, 1-13. doi

Dhara M, Yarzagaray A, Makke M, Schindeldecker B, Schwarz Y, Shaaban A, Sharma S, Böckmann RA, Lindau M, Mohrmann R, Bruns D.
v-SNARE transmembrane domains function as catalysts for vesicle fusion.
Elife. 2016, 5. see Faculty of 1000,Biology signifiant contribution. doi

Han J, Pluhackova K, Bruns D, Böckmann RA.
Synaptobrevin transmembrane domain determines the structure and dynamics of the SNARE motif and the linker region.
Biochim Biophys Acta. 2016, 1858, 855-65. doi

Mohrmann R, Dhara M, Bruns D.
Complexins: small but capable.
Cell Mol Life Sci. 2015, 72, 4221-35. Review. doi

Chang CW, Hui E, Bai J, Bruns D, Chapman ER, Jackson MB.
A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores.
J Neurosci. 2015, 35, 5772-80. doi

Dhara M, Yarzagaray A, Schwarz Y, Dutta S, Grabner C, Moghadam PK, Bost A, Schirra C, Rettig J, Reim K, Brose N, Mohrmann R, Bruns D.
Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics.
J Cell Biol. 2014, 204, 1123-40. doi

Mohrmann R, de Wit H, Connell E, Pinheiro PS, Leese C, Bruns D, Davletov B, Verhage M, Sørensen JB.
Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering.
J Neurosci. 2013, 33, 14417-30. doi

Matti U, Pattu V, Halimani M, Schirra C, Krause E, Liu Y, Weins L, Chang HF, Guzman R, Olausson J, Freichel M, Schmitz F, Pasche M, Becherer U, Bruns D, Rettig J.
Synaptobrevin2 is the v-SNARE required for cytotoxic T-lymphocyte lytic granule fusion.
Nat Commun. 2013, 4, 1439. doi

Borisovska M, Schwarz Y, Dhara M, Yarzagaray A, Hugo S, Narzi D, Siu SW, Kesavan J, Mohrmann R, Böckmann RA, Bruns D.
Membrane-proximal tryptophans of synaptobrevin II stabilize priming of secretory vesicles.
J Neurosci. 2012, 32, 15983-97. doi

Feldmann A1, Amphornrat J, Schönherr M, Winterstein C, Möbius W, Ruhwedel T, Danglot L, Nave KA, Galli T, Bruns D, Trotter J, Krämer-Albers EM.
Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7.
J Neurosci. 2011, 31, 5659-72. doi

Ngatchou AN, Kisler K, Fang Q, Walter AM, Zhao Y, Bruns D, Sørensen JB, Lindau M.
Role of the synaptobrevin C terminus in fusion pore formation.
Proc Natl Acad Sci U S A. 2010, 107, 18463-8. doi

Liu Y, Schirra C, Edelmann L, Matti U, Rhee J, Hof D, Bruns D, Brose N, Rieger H, Stevens DR, Rettig J.
Two distinct secretory vesicle-priming steps in adrenal chromaffin cells.
J Cell Biol. 2010, 190, 1067-77. doi

Guzman RE, Schwarz Y, Rettig J, Bruns D.
SNARE force synchronizes synaptic vesicle fusion and controls the kinetics of quantal synaptic transmission.
J Neurosci. 2010, 30, 10272-81. doi

Walter AM, Wiederhold K, Bruns D, Fasshauer D, Sørensen JB.
Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis.
J Cell Biol. 2010, 188, 401-13. doi

Gross SA, Guzmán GA, Wissenbach U, Philipp SE, Zhu MX, Bruns D, Cavalié A.
TRPC5 is a Ca2+-activated channel functionally coupled to Ca2+-selective ion channels.
J Biol Chem. 2009, 284, 34423-32. doi

Liu Y, Schirra C, Stevens DR, Matti U, Speidel D, Hof D, Bruns D, Brose N, Rettig J.
CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles.
J Neurosci. 2008, 28, 5594-601. doi

Kesavan J, Borisovska M, Bruns D.
v-SNARE actions during Ca(2+)-triggered exocytosis.
Cell. 2007 131, 351-63. See faculty of 1000, Major advances. doi

Borisovska M, Zhao Y, Tsytsyura Y, Glyvuk N, Takamori S, Matti U, Rettig J, Südhof T, Bruns D.
v-SNAREs control exocytosis of vesicles from priming to fusion.
EMBO J. 2005 Jun 15;24(12):2114-26. Epub 2005 May 26.doi

Schütz D, Zilly F, Lang T, Jahn R, Bruns D.
A dual function for Munc-18 in exocytosis of PC12 cells.
Eur J Neurosci. 2005, 21, 2419-32. doi

Speidel D, Bruederle CE, Enk C, Voets T, Varoqueaux F, Reim K, Becherer U, Fornai F, Ruggieri S, Holighaus Y, Weihe E, Bruns D, Brose N, Rettig J.
CAPS1 regulates catecholamine loading of large dense-core vesicles.
Neuron. 2005, 46, 75-88. doi

Bruns D.
Detection of transmitter release with carbon fiber electrodes.
Methods. 2004, 33, 312-21. doi

Yizhar O, Matti U, Melamed R, Hagalili Y, Bruns D, Rettig J, Ashery U.
Tomosyn inhibits priming of large dense-core vesicles in a calcium-dependent manner.
Proc Natl Acad Sci U S A. 2004, 101, 2578-83. doi

Hatsuzawa K, Lang T, Fasshauer D, Bruns D, Jahn R.
The R-SNARE motif of tomosyn forms SNARE core complexes with syntaxin 1 and SNAP-25 and down-regulates exocytosis.
J Biol Chem. 200, 278, 31159-66. doi

Bruns D, Jahn R.
Molecular determinants of exocytosis.
Pflugers Arch. 2002, 443, 333-8. doi

Bruns D, Riedel D, Klingauf J, Jahn R.
Quantal release of serotonin.
Neuron. 2000, 28, 205-20. doi

Bruns D.
Serotonin transport in cultured leech neurons.
Methods Enzymol. 1998, 296, 593-607. doi

Bruns D, Jahn R.
Monoamine transmitter release from small synaptic and large dense-core vesicles.
Adv Pharmacol. 1998, 42, 87-90. doi

Bruns D, Engers S, Yang C, Ossig R, Jeromin A, Jahn R.
Inhibition of transmitter release correlates with the proteolytic activity of tetanus toxin and botulinus toxin A in individual cultured synapses of Hirudo medicinalis.
J Neurosci. 1997, 17, 1898-910. doi

Fasshauer D, Bruns D, Shen B, Jahn R, Brünger AT.
A structural change occurs upon binding of syntaxin to SNAP-25.
J Biol Chem. 1997, 272, 4582-90. doi

Bruns D, Jahn R.
Real-time measurement of transmitter release from single synaptic vesicles.
Nature. 1995 , 377, 62-5. see also: Principles of Neuroscience, 4th edition, Editors Kandel E. R., Schwartz J.H, Jessel T.M., p.268. doi

Bruns D, Engert F, Lux HD.
A fast activating presynaptic reuptake current during serotonergic transmission in identified neurons of Hirudo.
Neuron. 1993, 10, 559-72. doi

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