Publications

Bröker-Lai J, Kollewe A, Schindeldecker B, Pohle J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weißgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Köhr G, Fakler B, Flockerzi V, Bruns D, Freichel M.Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory.EMBO J. 2017 Aug 8. pii: e201696369. doi: 10.15252/embj.201696369. [Epub ahead of print]PMID:28790178

Han J, Pluhackova K, Bruns D, Böckmann RA. Synaptobrevin transmembrane domain determines the structure and dynamics of the SNARE motif and the linker region. Biochim Biophys Acta. 2016 Apr;1858(4):855-65. doi: 10.1016/j.bbamem.2016.01.030. PMID:26851777

Mohrmann R, Dhara M, Bruns D. Complexins: small but capable. Cell Mol Life Sci. 2015 Nov;72(22):4221-35. doi: 10.1007/s00018-015-1998-8. Review. PMID:26245303

Chang CW, Hui E, Bai J, Bruns D, Chapman ER, Jackson MB. A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores. J Neurosci. 2015 Apr 8;35(14):5772-80. doi: 10.1523/JNEUROSCI.3983-14.2015.PMID:25855187

Dhara M, Yarzagaray A, Schwarz Y, Dutta S, Grabner C, Moghadam PK, Bost A, Schirra C, Rettig J, Reim K, Brose N, Mohrmann R, Bruns D. Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics. J Cell Biol. 2014 Mar 31;204(7):1123-40. doi: 10.1083/jcb.201311085. PMID:24687280

Mohrmann R, de Wit H, Connell E, Pinheiro PS, Leese C, Bruns D, Davletov B, Verhage M, Sørensen JB. Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering. J Neurosci. 2013 Sep 4;33(36):14417-30. doi: 10.1523/JNEUROSCI.1236-13.2013. PMID:24005294

Matti U, Pattu V, Halimani M, Schirra C, Krause E, Liu Y, Weins L, Chang HF, Guzman R, Olausson J, Freichel M, Schmitz F, Pasche M, Becherer U, Bruns D, Rettig J. Synaptobrevin2 is the v-SNARE required for cytotoxic T-lymphocyte lytic granule fusion. Nat Commun. 2013;4:1439. doi: 10.1038/ncomms2467. PMID:23385584

Borisovska M, Schwarz YN, Dhara M, Yarzagaray A, Hugo S, Narzi D, Siu SW, Kesavan J, Mohrmann R, Böckmann RA, Bruns D. Membrane-proximal tryptophans of synaptobrevin II stabilize priming of secretory vesicles. J Neurosci. 2012 Nov 7;32(45):15983-97. doi: 10.1523/JNEUROSCI.6282-11.2012. [Supplemental Figure: Borisovska_et_al_Supp_Fig.pdf] PMID:23136435

Feldmann A, Amphornrat J, Schönherr M, Winterstein C, Möbius W, Ruhwedel T, Danglot L, Nave KA, Galli T, Bruns D, Trotter J, Krämer-Albers EM. Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7. J Neurosci. 2011 Apr 13;31(15):5659-72. doi: 10.1523/JNEUROSCI.6638-10.2011. PMID:21490207

Ngatchou AN, Kisler K, Fang Q, Walter AM, Zhao Y, Bruns D, Sørensen JB, Lindau M. Role of the synaptobrevin C terminus in fusion pore formation. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18463-8. doi: 10.1073/pnas.1006727107. PMID:20937897

Liu Y, Schirra C, Edelmann L, Matti U, Rhee J, Hof D, Bruns D, Brose N, Rieger H, Stevens DR, Rettig J. Two distinct secretory vesicle-priming steps in adrenal chromaffin cells. J Cell Biol. 2010 Sep 20;190(6):1067-77. doi: 10.1083/jcb.201001164.PMID:20855507

Guzman RE, Schwarz YN, Rettig J, Bruns D. SNARE force synchronizes synaptic vesicle fusion and controls the kinetics of quantal synaptic transmission. J Neurosci. 2010 Aug 4;30(31):10272-81. doi: 10.1523/JNEUROSCI.1551-10.2010. see Faculty of 1000, Biology, good paper. PMID:20685972

Walter AM, Wiederhold K, Bruns D, Fasshauer D, Sørensen JB. Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis. J Cell Biol. 2010 Feb 8;188(3):401-13. doi: 10.1083/jcb.200907018.PMID:20142423

Gross SA, Guzmán GA, Wissenbach U, Philipp SE, Zhu MX, Bruns D, Cavalié A. TRPC5 is a Ca2+-activated channel functionally coupled to Ca2+-selective ion channels. J Biol Chem. 2009 Dec 4;284(49):34423-32. doi: 10.1074/jbc.M109.018192. PMID:19815560

Liu Y, Schirra C, Stevens DR, Matti U, Speidel D, Hof D, Bruns D, Brose N, Rettig J. CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles. J Neurosci. 2008 May 21;28(21):5594-601. doi: 10.1523/JNEUROSCI.5672-07.2008. PMID:18495893

Kesavan J, Borisovska M, Bruns D. v-SNARE actions during Ca(2+)-triggered exocytosis. Cell. 2007 Oct 19;131(2):351-63. see Faculty of 1000, Biology, Major advances. PMID:17956735

Borisovska M, Zhao Y, Tsytsyura Y, Glyvuk N, Takamori S, Matti U, Rettig J, Südhof T, Bruns D. v-SNAREs control exocytosis of vesicles from priming to fusion. EMBO J. 2005 Jun 15;24(12):2114-26. PMID:15920476

Schütz D, Zilly F, Lang T, Jahn R, Bruns D. A dual function for Munc-18 in exocytosis of PC12 cells. Eur J Neurosci. 2005 May;21(9):2419-32. PMID:15932600

Speidel D, Bruederle CE, Enk C, Voets T, Varoqueaux F, Reim K, Becherer U, Fornai F, Ruggieri S, Holighaus Y, Weihe E, Bruns D, Brose N, Rettig J. CAPS1 regulates catecholamine loading of large dense-core vesicles. Neuron. 2005 Apr 7;46(1):75-88. PMID:15820695

Bruns D. Detection of transmitter release with carbon fiber electrodes. Methods. 2004 Aug;33(4):312-21. PMID:15183180

Yizhar O, Matti U, Melamed R, Hagalili Y, Bruns D, Rettig J, Ashery U. Tomosyn inhibits priming of large dense-core vesicles in a calcium-dependent manner. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2578-83. PMID:14983051

Hatsuzawa K, Lang T, Fasshauer D, Bruns D, Jahn R. The R-SNARE motif of tomosyn forms SNARE core complexes with syntaxin 1 and SNAP-25 and down-regulates exocytosis. J Biol Chem. 2003 Aug 15;278(33):31159-66. PMID:12782620

Bruns D, Jahn R. Molecular determinants of exocytosis. Pflugers Arch. 2002 Jan;443(3):333-8. Review. PMID:11810200

Lang T, Bruns D, Wenzel D, Riedel D, Holroyd P, Thiele C, Jahn R. SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis. EMBO J. 2001 May 1;20(9):2202-13. PMID:11331586

Bruns D, Riedel D, Klingauf J, Jahn R. Quantal release of serotonin. Neuron. 2000 Oct;28(1):205-20. PMID:11086995

Bruns D. Serotonin transport in cultured leech neurons. Methods Enzymol. 1998;296:593-607. No abstract available. PMID:9779476

Bruns D, Jahn R. Monoamine transmitter release from small synaptic and large dense-core vesicles. Adv Pharmacol. 1998;42:87-90. No abstract available. PMID:9327853

Bruns D, Engers S, Yang C, Ossig R, Jeromin A, Jahn R. Inhibition of transmitter release correlates with the proteolytic activity of tetanus toxin and botulinus toxin A in individual cultured synapses of Hirudo medicinalis. J Neurosci. 1997 Mar 15;17(6):1898-910. PMID:9045719

Fasshauer D, Bruns D, Shen B, Jahn R, Brünger AT. A structural change occurs upon binding of syntaxin to SNAP-25. J Biol Chem. 1997 Feb 14;272(7):4582-90. PMID:9020186

Bruns D, Jahn R. Real-time measurement of transmitter release from single synaptic vesicles. Nature. 1995 Sep 7;377(6544):62-5. see also: Principles of Neuroscience, 4th edition, Editors Kandel E. R., Schwartz J.H, Jessel T.M., p.268. PMID:7659162

Bruns D, Engert F, Lux HD. A fast activating presynaptic reuptake current during serotonergic transmission in identified neurons of Hirudo. Neuron. 1993 Apr;10(4):559-72. PMID:8386524

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