Publications 2022

IDO1 is highly expressed in macrophages of patients in advanced tumour stages of oral squamous cell carcinoma
Ann-Kristin Struckmeier, Anne Radermacher, Michael Fehrenz, Tamara Bellin, Dalia Alansary, Philipp Wartenberg, Ulrich Boehm, Mathias Wagner, Anja Scheller, Jochen Hess, Julius Moratin, Christian Freudlsperger, Jürgen Hoffmann, Lorenz Thurner , Klaus Roemer, Kolja Freier, Dominik Horn
J Cancer Res Clin Oncol. 2022 Aug 13. doi: 10.1007/s00432-022-04277-7. Online ahead of print.

Targeting Pancreatic Islet NLRP3 Improves Islet Graft Revascularization
Selina Wrublewsky, Thimoteus Speer, Lisa Nalbach, Anne S Boewe, Mandy Pack, Dalia Alansary, Leticia P Roma, Markus D A Hoffmann, Beate M Schmitt, Andrea Weinzierl, Michael D Menger, Matthias W Laschke, Emmanuel Ampofo
Diabetes.2022 Aug 1;71(8):1706-1720. doi: 10.2337/db21-0851.

X-ray irradiation triggers immune response in human T-lymphocytes via store-operated Ca2+ entry and NFAT activation
Dominique Tandl, Tim Sponagel, Dalia Alansary, Sebastian Fuck, Timo Smit, Stephanie Hehlgans, Burkhard Jakob, Claudia Fournier, Barbara A Niemeyer, Franz Rödel, Bastian Roth, Anna Moroni, Gerhard Thiel
J Gen Physiol. 2022 May 2;154(5):e202112865. doi: 10.1085/jgp.202112865. Epub 2022 Apr 13.

Cytotoxic Efficiency of Human CD8(+) T Cell Memory Subtypes.
Knorck A, Schafer G, Alansary D, Richter J, Thurner L, Hoth M, Schwarz EC.
Front. Immunol., 13 April 2022 Sec.T Cell Biology

Publications 2021

A longer isoform of Stim1 is a negative SOCE regulator but increases cAMP-modulated NFAT signaling.
Knapp ML, Alansary D, Poth V, Förderer K, Sommer F, Zimmer D, Schwarz Y, Künzel N, Kless A, Machaca K, Helms V, Mühlhaus T, Schroda M, Lis A, Niemeyer BA.
EMBO Reports. 2021 Dec 23;23(3):e53135

Interleukin-1α Is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease
Stefan J Schunk, Sarah Triem, David Schmit, Stephen Zewinger, Tamim Sarakpi, Ellen Becker, Gregor Hütter, Selina Wrublewsky, Fabienne Küting, Mathias Hohl, Dalia Alansary, Leticia Prates Roma, Peter Lipp, Julia Möllmann, Michael Lehrke, Matthias W Laschke, Michael D Menger, Rafael Kramann, Peter Boor, Willi Jahnen-Dechent, Winfried März, Michael Böhm, Ulrich Laufs, Barbara A Niemeyer, Danilo Fliser, Emmanuel Ampofo, Thimoteus Speer
Circulation. 2021 Sep 14;144(11):893-908.doi: 10.1161/CIRCULATIONAHA.121.053547. Epub 2021 Jul 1.

Targeting the Microtubule-Network Rescues CTL Killing Efficiency in Dense 3D Matrices.
Zhao R, Zhou X, Khan ES, Alansary D, Friedmann KS, Yang W, Schwarz EC, Del Campo A, Hoth M, Qu B.
Front. Immunol., 17 August 2021 Sec.T Cell Biology

Supra-Molecular assemblies of ORAI1 at rest precede local accumulation into puncta after activation
Diana B. Peckys, Daniel Gaa, Dalia Alansary, Barbara A. Niemeyer, Niels de Jonge
Int J Mol Sci. 2021 Jan 14;22(2):799. doi: 10.3390/ijms22020799

Publications 2020

High glucose distinctively regulates Ca2+ influx in cytotoxic T lymphocytes upon target recognition and thapsigargin stimulation.
Zou H, Yang W, Schwär G, Zhao R, Alansary D, Yin D, Schwarz EC, Niemeyer BA, Qu B.
Eur J Immunol. 2020 Dec;50(12):2095-2098. doi: 10.1002/eji.202048577. Epub 2020 Aug 18

Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry.
Gibhardt CS, Cappello S, Bhardwaj R, Schober R, Kirsch SA, Bonilla Del Rio Z, Gahbauer S, Bochicchio A, Sumanska M, Ickes C, Stejerean-Todoran I, Mitkovski M, Alansary D, Zhang X, Revazian A, Fahrner M, Lunz V, Frischauf I, Luo T, Ezerina D, Messens J, Belousov VV, Hoth M, Böckmann RA, Hediger MA, Schindl R, Bogeski I.
Cell Rep. 2020 Oct 20;33(3):108292. doi : 10.1016/j.celrep.2020.108292.

Detecting single ORAI1 proteins within the plasma membrane reveals higher-order channel complexes.
Alansary D, Peckys DB, Niemeyer BA, de Jonge N.
Journal of Cell Science. 2020;133:jcs240358 doi: 10.1242/jcs.240358 Published 3 January 2020

Publications 2019

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation.
Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, Klug M, Schunk SJ, Schmit D, Kramann R, Körbel C, Ampofo E, Laschke MW, Selejan SR, Paschen A, Herter T, Schuster S, Silbernagel G, Sester M, Sester U, Aßmann G, Bals R, Kostner G, Jahnen-Dechent W, Menger MD, Rohrer L, März W, Böhm M, Jankowski J, Kopf M, Latz E, Niemeyer BA, Fliser D, Laufs U, Speer T.
Nature Immunology 2019 Dec 09;21: 30–41(2020)

Reaction-diffusion model for STIM-ORAI interaction: the role of ROS and mutations.
Schmidt B, Alansary D, Bogeski I, Niemeyer BA, Rieger H.
J Theor Biol. 2019 Jun 7;470:64-75.

Stepping out of the shadow: STIM2 promotes IL-3–induced cytokine release.
Alansary D, Niemeyer BA.
Science Singaling 2019 Apr 09;12(576):eaax0210

Publications 2018

Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis.
Riva B, Griglio A, Serafini M, Cordero-Sanchez C, Aprile S, Di Paola R, Gugliandolo E, Alansary D, Biocotino I, Lim D, Grosa G, Galli U, Niemeyer B, Sorba G, Canonico PL, Cuzzocrea S, Genazzani AA, Pirali T.
J Med Chem. 2018 Nov 8;61(21):9756-9783. doi: 10.1021/acs.jmedchem.8b01512. Epub 2018 Oct 30.

Modulation of intracellular calcium signaling by microRNA-34a-5p.
Diener C, Hart M, Alansary D, Poth V, Walch-Rückheim B, Menegatti J, Grässer F, Fehlmann T, Rheinheimer S, Niemeyer BA, Lenhof HP, Keller A, Meese E.
Cell Death & Disease. 2018 Sep 27;9:1008 (2018)

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.
Bunse L, Pusch S, Bunse T, Sahm F, Sanghvi K, Friedrich M, Alansary D, Sonner JK, Green E, Deumelandt K, Kilian M, Neftel C, Uhlig S, Kessler T, von Landenberg A, Berghoff AS, Marsh K, Steadman M, Zhu D, Nicolay B, Wiestler B, Breckwoldt MO, Al-Ali R, Karcher-Bausch S, Bozza M, Oezen I, Kramer M, Meyer J, Habel A, Eisel J, Poschet G, Weller M, Preusser M, Nadji-Ohl M, Thon N, Burger MC, Harter PN, Ratliff M, Harbottle R, Benner A, Schrimpf D, Okun J, Herold-Mende C, Turcan S, Kaulfuss S, Hess-Stumpp H, Bieback K, Cahill DP, Plate KH, Hänggi D, Dorsch M, Suvà ML, Niemeyer BA, von Deimling A, Wick W, Platten M.
Nat Med. 2018 Aug;24(8):1192-1203. doi: 10.1038/s41591-018-0095-6. Epub 2018 Jul 9.

Profiling calcium signals of in vitro polarized human effector CD4+ T cells.
Kircher S, Merino-Wong M, Niemeyer BA, Alansary D.
Biochim. Biophys. Acta Mol. Cell Res. 2018 Jun; 1865(6):932-943.

Publications 2016

Thiol dependant intramolecular locking of Orai1 channels.
Alansary D, Schmidt B, Dörr K, Bogeski I, Rieger H, Kless A, Niemeyer BA.
Sci. Rep. 6. 2016 Sep 14;33347(2016).

Visualizing Quantum Dot Labeled ORAI1 Proteins in intact Cells via correlative kight and electron microscopy.
Peckys DB, Alansary D, Niemeyer BA, de Jonge N.
Microsc Microanal. 2016 Aug;22(4):902-12.

Cell type-specific glycosylation of Orai1 modulates store-operated Ca2+ entry.
Dörr K, Kilch T, Kappel S, Alansary D, Schwär G, Niemeyer BA, Peinelt C.
Sci Signal. 2016 Mar 8;9(418):ra25.

Publications 2015

A STIM2 splice variant negatively regulates store-operated calcium entry.
Miederer AM, Alansary D, Schwär G, Lee PH, Jung M, Helms V, Niemeyer BA.
Nat Commun. 2015 Apr 21;6:6899. doi: 10.1038/ncomms7899.

Facilitation of Orai3 targeting and store-operated function by Orai1.
Alansary D, Bogeski I, Niemeyer BA.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2015 Mar; 1853(7):1541-1550.

Publications 2014

Patch-clamp measurement of ICRAC and ORAI channel activity.
Alansary D, Kilch T, Holzmann C, Peinelt C, Hoth M, Lis A.
Cold Spring Harb Protoc. 2014 Jun 2;2014(6):602-7. doi: 10.1101/pdb.top066795.

The minimal requirements to use calcium imaging to analyze ICRAC.
Alansary D, Kilch T, Holzmann C, Peinelt C, Hoth M, Lis A.
Cold Spring Harb Protoc. 2014 Jun 2;2014(6):638-42. doi: 10.1101/pdb.prot073262.

Measuring endogenous ICRAC and ORAI currents with the patch-clamp technique.
Alansary D, Kilch T, Holzmann C, Peinelt C, Hoth M, Lis A.
Cold Spring Harb Protoc. 2014 Jun 2;2014(6):630-7. doi: 10.1101/pdb.prot073254.

Publications 2013

Mutations of the Ca2+-sensing Stromal Interaction Molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1
Kilch T, Alansary D, Peglow M, Doerr K, Rychkov G, Rieger H, Peinelt C, Niemeyer BA.
Journal of Biological Chemistry. 2013 Jan 18;288:1653-1664

Publications 2011

Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation.
Quintana A, Pasche M, Junker C, Alansary D, Rieger H, Kummerow C, Nuñez L, Villalobos C, Meraner P, Becherer U, Rettig J, Niemeyer BA, Hoth M.
The EMBO Journal advance online publication 16 August 2011; doi:10.1038/emboj.2011.289 Published online: 16 August 2011

ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance.
Qu B, Alansary D, Kummerow C, Hoth M, Schwarz EC.
Cell Calcium. 2011 Jun 10. [Epub ahead of print]

Publications 2010

Pharmacology of ORAI channels as a tool to understand their physiological functions.
Bogeski I, Alansary D, Qu B, Niemeyer BA, Hoth M, Peinelt C.
Expert Review of Clinical Pharmacology (2010 May);3 (3):291-303.

Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling.
Bogeski I, Kummerov C, Alansary D, Schwarz EC, Koehler R, Kozai D, Takahashi N, Peinelt C, Griesemer D, Bozem M, Mori Y, Hoth M, Niemeyer BA.
Sci Signal. (2010 Mar 30);3 (115):ra24.

ATP modulates Ca2+ uptake by TRPV6 and is counteracted by isoform-specific phosphorylation.
Alansary D, Bogeski I, Disteldorf BM, Becherer U, Niemeyer BA.
FASEB J. (2010 Feb);24(2):425-35. Epub 2009 Oct 5.