Immune Physiology

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Publications 2023

Regio- and stereoselective steroid hydroxylation by CYP109A2 from Bacillus megaterium explored by X-ray crystallography and computational modeling.
Ilona K Jóźwik, Elvira Bombino, Ammar Abdulmughni,Philip Hartz, Henriette J Rozeboom, Hein J Wijma, Reinhard Kappl, Dick B Janssen, Rita Bernhardt, Andy-Mark W H Thunnissen
FEBS J. 2023 Jul 15. doi: 10.1111/febs.16906. Online ahead of print.

Heterozygous OT-I mice reveal that antigen-specific CD8+ T cells shift from apoptotic to necrotic killers in the elderly.
Dorina Zöphel D, Lea Kaschek L, Romy Steiner R, Sandra Janu S, Hsin-Fang Chang HS, Lis A
Aging Cell. 2023 Jun;22(6):e13824. doi: 10.1111/acel.13824. Epub 2023 Mar 22.

Interleukin-27 potentiates CD8+ T-cell-mediated anti-tumor immunity in chronic lymphocytic leukemia.
Giulia Pagano, Iria Fernandez Botana, Marina Wierz, Philipp M Roessner, Nikolaos Ioannou, Xiangda Zhou, Gheed Al-Hity, Coralie Borne, Ernesto Gargiulo, Susanne Gonder, Bin Qu, Basile Stamatopoulos, Alan G Ramsay, Martina Seiffert, Anne Largeot, Etienne Moussay, Jerome Paggetti
Haematologica. 2023 Jun 22. doi: 10.3324/haematol.2022.282474. Online ahead of print.

DOPA Residues Endow Collagen with Radical Scavenging Capacity.
Markus Kurth, Uladzimir Barayeu, Hassan Gharibi, Andrei Kuzhelev, Kai Riedmiller, Jennifer Zilke, Kasimir Noack, Vasyl Denysenkov, Reinhard Kappl, Thomas F Prisner, Roman A Zubarev, Tobias P Dick, Frauke Gräter
Angew Chem Int Ed Engl. 2023 Jun 12;62(24):e202216610. doi: 10.1002/anie.202216610. Epub 2023 May 4.

Elderly CD8+ T cells in the focus for immunotherapeutic approaches.
Annette Lis, Dorina Zöphel.
Aging (Albany NY). 2023 May 18;15(10):3899-3900. doi: 10.18632/aging.204747. Epub 2023 May 18.

B-cell receptor reactivity against Rothia mucilaginosa in nodular lymphocyte-predominant Hodgkin lymphoma.
Lorenz Thurner, Natalie Fadle, Evi Regitz, Sophie Roth, Onur Cetin, Igor Age Kos, Simon Mauro Hess, Julia Bein, Rainer Maria Bohle, Martine Vornanen, Christer Sundström, Laurence De Leval, Enrico Tiacci, Peter Borchmann, Andreas Engert, Viola Poeschel, Gerhard Held, Eva C Schwarz, Frank Neumann, Klaus-Dieter Preuss, Markus Hoth, Ralf Küppers, Karola Lehman, Martin-Leo Hansmann, Sören L Becker, Moritz Bewarder, Sylvia Hartmann
Haematologica. 2023 May 4. doi: 10.3324/haematol.2023.282698. Online ahead of print.

Identification of molecular candidates which regulate calcium-dependent CD8+ T-cell cytotoxicity.
Sylvia Zöphel, Gertrud Schäfer, Maryam Nazarieh, Verena Konetzki, Cora Hoxha, Eckart Meese, Markus Hoth, Volkhard Helms, Mohamed Hamed, Eva C Schwarz
Mol Immunol. 2023 May;157:202-213. doi: 10.1016/j.molimm.2023.04.002. Epub 2023 Apr 17.

Ars2-containing bispecific, Fab- and IgG1-format BAR-bodies to target DLBCL cells.
Kiefer M, Thurner L, Bock T, Cetin O, Kos I, Lesan V, Kaddu-Mulindwa D, Bittenbring JT, Fadle N, Regitz E, Hoth M, Neumann F, Preuss KD, Pfreundschuh M, Christofyllakis K, Bewarder M.
EJHaem. 2022 Dec 27;4(1):125-134. doi: 10.1002/jha2.635. eCollection 2023 Feb.

Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals.
Barayeu U, Schilling D, Eid M, Xavier da Silva TN, Schlicker L, Mitreska N, Zapp C, Gräter F, Miller AK, Kappl R, Schulze A, Friedmann Angeli JP, Dick TP.
Nat Chem Biol. 2023 Jan;19(1):28-37. doi: 10.1038/s41589-022-01145-w. Epub 2022 Sep 15.

The calcium channel modulator 2-APB hydrolyzes in physiological buffers and acts as an effective radical scavenger and inhibitor of the NADPH oxidase 2.
Slowik EJ, Stankoska K, Bui NN, Pasieka B, Conrad D, Zapp J, Hoth M, Bogeski I, Kappl R.
Redox Biol. 2023 Mar 4;61:102654. doi: 10.1016/j.redox.2023.102654. Online ahead of print.

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Publications 2022

Interdependence of sequential cytotoxic T lymphocyte and natural killer cell cytotoxicity against melanoma cells.
Friedmann KS, Kaschek L, Knörck A, Cappello S, Lünsmann N, Küchler N, Hoxha C, Schäfer G, Iden S, Bogeski I, Kummerow C, Schwarz EC, Hoth M.
J Physiol. 2022 Dec;600(23):5027-5054. doi: 10.1113/JP283667. Epub 2022 Nov 3.

MCU controls melanoma progression through a redox-controlled phenotype switch.
Stejerean-Todoran I, Zimmermann K, Gibhardt CS, Vultur A, Ickes C, Shannan B, Bonilla Del Rio Z, Wölling A, Cappello S, Sung HM, Shumanska M, Zhang X, Nanadikar M, Latif MU, Wittek A, Lange F, Waters A, Brafford P, Wilting J, Urlaub H, Katschinski DM, Rehling P, Lenz C, Jakobs S, Ellenrieder V, Roesch A, Schön MP, Herlyn M, Stanisz H, Bogeski I.
EMBO Rep. 2022 Nov 7;23(11):e54746. doi: 10.15252/embr.202254746. Epub 2022 Sep 26.

Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1.
Sahoo N, Yang K, Coburger I, Bernert A, Swain SM, Gessner G, Kappl R, Kühl T, Imhof D, Hoshi T, Schönherr R, Heinemann SH.
Sci Rep. 2022 Aug 27;12(1):14645. doi: 10.1038/s41598-022-18975-2.

Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxic CD8+ T cells boost cancer cell elimination.
Zöphel D, Angenendt A, Kaschek L, Ravichandran K, Hof C, Janku S, Hoth M, Lis A.
Aging Cell. 2022 Aug;21(8):e13668. doi: 10.1111/acel.13668. Epub 2022 Jul 11.

The loss of pancreatic islet NADPH oxidase (NOX)2 improves islet transplantation.
Wrublewsky S, Glas J, Carlein C, Nalbach L, Hoffmann MDA, Pack M, Vilas-Boas EA, Ribot N, Kappl R, Menger MD, Laschke MW, Ampofo E, Roma LP.
Redox Biol. 2022 Jul 31;55:102419. doi: 10.1016/j.redox.2022.102419. Online ahead of print.

B-cell receptors of EBV-negative Burkitt lymphoma bind modified isoforms of autoantigens.
Bock T, Bewarder M, Cetin O, Fadle N, Regitz E, Schwarz EC, Held J, Roth S, Lohse S, Pfuhl T, Wagener R, Smola S, Becker SL, Bohle RM, Trümper L, Siebert R, Hansmann ML, Pfreundschuh M, Drexler HG, Hoth M, Kubuschok B, Roemer K, Preuss KD, Hartmann S, Thurner L.
EJHaem. 2022 Jun 16;3(3):739-747. doi: 10.1002/jha2.475. eCollection 2022 Aug.

Cytotoxic Efficiency of Human CD8(+) T Cell Memory Subtypes.
Knorck A, Schafer G, Alansary D, Richter J, Thurner L, Hoth M, Schwarz EC.
Front. Immunol., 13 April 2022, Sec.T Cell Biology

On the Connections between TRPM Channels and SOCE.
Souza Bomfim GH, Niemeyer BA, Lacruz RS, Lis A.
Cells. 2022 Apr 1;11(7):1190.

doi: 10.3390/cells11071190.

Unspecific CTL Killing Is Enhanced by High Glucose via TNF-Related Apoptosis-Inducing Ligand.
Yang W, Denger A, Diener C, Kuppers F, Soriano-Baguet L, Schafer G, Yanamandra AK, Zhao R, Knorck A, Schwarz EC, Hart M, Lammert F, Roma LP, Brenner D, Christidis G, Helms V, Meese E, Hoth M, Qu B.
Front. Immunol., 21 February 2022
Sec.T Cell Biology

KIR2DS1-HLA-C status as a predictive marker for benefit from rituximab: a post-hoc analysis of the RICOVER-60 and CLL8 trials.
Kaddu-Mulindwa D, Altmann B, Robrecht S, Ziepert M, Regitz E, Tausch E, Held G, Poeschel V, Lesan V, Bittenbring JT, Thurner L, Pfreundschuh M, Christofyllakis K, Truemper L, Loeffler M, Schmitz N, Hoth M, Hallek M, Fischer K, Stilgenbauer S, Bewarder M, Rixecker TM.
Lancet Haematol. 2022 Feb;9(2):e133-e142.

A longer isoform of Stim1 is a negative SOCE regulator but increases cAMP-modulated NFAT signaling.
Mona L Knapp, Dalia Alansary, Vanessa Poth, Kathrin Förderer, Frederik Sommer, David Zimmer, Yvonne Schwarz, Nicolas Künzel, Achim Kless, Khaled Machaca, Volkhard Helms, Timo Mühlhaus, Michael Schroda, Annette Lis, Barbara A Niemeyer.
EMBO Rep. 2022 Feb 3;23(3):e53135. doi: 10.15252/embr.202153135. Epub 2021 Dec 23.

Bacterial identification and adhesive strength evaluation based on a mannose biosensor with dual-mode detection.
Cui F, Shen X, Cao B, Ji H, Liu J, Zhuang X, Zeng C, Qu B, Li S, Xu Y, Zhou Q.
Biosens Bioelectron. 2022 May 1;203:114044. doi: 10.1016/j.bios.2022.114044. Epub 2022 Jan 30

Imaging Erythrocyte Sedimentation in Whole Blood.
Darras A, Breunig HG, John T, Zhao R, Koch J, Kummerow C, König K, Wagner C, Kaestner L.
Front Physiol. 2022 Jan 28;12:729191. doi: 10.3389/fphys.2021.729191. eCollection 2021.

Light-Sheet Scattering Microscopy to Visualize Long-Term Interactions Between Cells and Extracellular Matrix.
Zhou X, Zhao R, Yanamandra AK, Hoth M, Qu B.
Front. Immunol., 28 January 2022
Sec.T Cell Biology

Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy.
Särchen V, Shanmugalingam S, Kehr S, Reindl LM, Greze V, Wiedemann S, Boedicker C, Jacob M, Bankov K, Becker N, Wehner S, Theilen TM, Gretser S, Gradhand E, Kummerow C, Ullrich E, Vogler M.
Cell Death Discov. 2022 Jan 11;8(11). doi.org/10.1038/s41420-021-00812-6

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Publications 2021

Loss of Mitochondrial Ca(2+) Uniporter Limits Inotropic Reserve and Provides Trigger and Substrate for Arrhythmias in Barth Syndrome Cardiomyopathy.
Bertero E, Nickel A, Kohlhaas M, Hohl M, Sequeira V, Brune C, Schwemmlein J, Abesser M, Schuh K, Kutschka I, Carlein C, Munker K, Atighetchi S, Muller A, Kazakov A, Kappl R, von der Malsburg K, van der Laan M, Schiuma AF, Bohm M, Laufs U, Hoth M, Rehling P, Kuhn M, Dudek J, von der Malsburg A, Prates Roma L, Maack C.
Circulation. 2021 Oct 14;144:1694–1713

Protein Signatures of NK Cell-Mediated Melanoma Killing Predict Response to Immunotherapies.
Cappello S, Sung HM, Ickes C, Gibhardt CS, Vultur A, Bhat H, Hu Z, Brafford P, Denger A, Stejerean-Todoran I, Kohn RM, Lorenz V, Kunzel N, Salinas G, Stanisz H, Legler T, Rehling P, Schon MP, Lang KS, Helms V, Herlyn M, Hoth M, Kummerow C, Bogeski I.
Cancer Research. 2021 Sep;81(21):canres.CAN-21-0164-A.2021

Targeting the Microtubule-Network Rescues CTL Killing Efficiency in Dense 3D Matrices.
Zhao R, Zhou X, Khan ES, Alansary D, Friedmann KS, Yang W, Schwarz EC, Del Campo A, Hoth M, Qu B.
Front. Immunol., 17 August 2021
Sec.T Cell Biology

T cell stiffness is enhanced upon formation of immunological synapse.
Jung P, Zhou X, Iden S, Bischoff M, Qu B.
Elife. 2021 Jul 27;10:e66643. doi: 10.7554/eLife.66643

A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity.
Kaschek L, Zöphel S, Knörck A, Hoth M.
Semin Cell Dev Biol. 2021 Jul;115:10-18. doi: 10.1016/j.semcdb.2020.12.002. Epub 2021 Jan 6. PMID: 33358089 Free article. Review.

The B-cell Receptor Autoantigen LRPAP1 Can Replace Variable Antibody Regions to Target Mantle Cell Lymphoma Cells.
Bewarder M, Kiefer M, Will H, Olesch K, Moelle C, Stilgenbauer S, Christofyllakis K, Kaddu-Mulindwa D, Bittenbring JT, Fadle N, Regitz E, Kaschek L, Hoth M, Neumann F, Preuss KD, Pfreundschuh M, Thurner L.
Hemasphere. 2021 Jul 13;5(8):e620. doi: 10.1097/HS9.0000000000000620. eCollection 2021 Aug.  PMID: 34263144 Free PMC article.

Profiling of cytokines, chemokines and growth factors in saliva and gingival crevicular fluid.
Liu Y, Zhao R, Reda B, Yang W, Hannig M, Qu B.
Cytokine. 2021 Jun;142:155504

High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity.
Zhu J, Yang W, Zhou X, Zöphel D, Soriano-Baguet L, Dolgener D, Carlein C, Hof C, Zhao R, Ye S, Schwarz EC, Brenner D, Prates Roma L, Qu B.
Front Immunol. 2021 Jun 25;12:689337. doi: 10.3389/fimmu.2021.689337. eCollection 2021. PMID: 34248978 Free PMC article.

Optoregulated force application to cellular receptors using molecular motors.
Zheng Y, Han MKL, Zhao R, Blass J, Zhang J, Zhou DW, Colard-Itté JR, Dattler D, Çolak A, Hoth M, García AJ, Qu B, Bennewitz R, Giuseppone N, Del Campo A.
Nat Commun. 2021 Jun 11;12(1):3580. doi: 10.1038/s41467-021-23815-4.  PMID: 34117256 Free PMC article.

Blockade of PD-1 decreases neutrophilic inflammation and lung damage in experimental COPD.
Ritzmann F, Borchardt K, Vella G, Chitirala P, Angenendt A, Herr C, Menger MD, Hoth M, Lis A, Bohle RM, Bals R, Beisswenger C.
Am J Physiol Lung Cell Mol Physiol. 2021 May 1;320(5):L958-L968. doi: 10.1152/ajplung.00121.2020. Epub 2021 Mar 24. PMID: 33759577

Characterization of immune cell migration using microfabrication.
Vesperini D, Montalvo G, Qu B, Lautenschläger F.
Biophys Rev 13, 185–202 (2021). doi.org/10.1007/s12551-021-00787-9

Micropatterned soft hydrogels to study the interplay of receptors and forces in T cell activation.
Zhang J, Zhao R, Li B, Farrukh A, Hoth M, Qu B, Del Campo
A. Acta Biomater. 2021 Jan 1;119:234-246. doi: 10.1016/j.actbio.2020.10.028. Epub 2020 Oct 21. PMID: 33099024

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Publications 2020

High glucose distinctively regulates Ca2+ influx in cytotoxic T lymphocytes upon target recognition and thapsigargin stimulation.
Zou H, Yang W, Schwär G, Zhao R, Alansary D, Yin D, Schwarz EC, Niemeyer BA, Qu B.
Eur J Immunol. 2020 Dec;50(12):2095-2098. doi: 10.1002/eji.202048577. Epub 2020 Aug 18

Altered Ca2+ Homeostasis in Immune Cells during Aging: Role of Ion Channels.
Zöphel D, Hof C, Lis A.
Int J Mol Sci. 2020 Dec 24;22(1):110. doi: 10.3390/ijms22010110.

Role of Specific B-Cell Receptor Antigens in Lymphomagenesis.
Thurner L, Hartmann S, Neumann F, Hoth M, Stilgenbauer S, Küppers R, Preuss KD, Bewarder M.
Front Oncol. 2020 Dec 9;10:604685. doi: 10.3389/fonc.2020.604685. eCollection 2020. PMID: 33363034 Free PMC article. Review.

Interorganelle Tethering to Endocytic Organelles Determines Directional Cytokine Transport in CD4+ T Cells.
Zhou Y, Zhao R, Schwarz EC, Akbar R, Kaba M, Pattu V, Helms V, Rieger H, Nunes-Hasler P, Qu B.
J Immunol. 2020 Dec 1;205(11):2988-3000. doi: 10.4049/jimmunol.2000195. Epub 2020 Oct 26.

Migration of Cytotoxic T Lymphocytes in 3D Collagen Matrices.
Sadjadi Z, Zhao R, Hoth M, Qu B, Rieger H.
Biophys J. 2020 Dec 1;119(11):2141-2152. doi: 10.1016/j.bpj.2020.10.020.

Experimental induction of blunt chest trauma in mice: A modified approach with evaluation in dummies and cadavers.
Höfer D, Körbel C, Laschke MW, Veith NT, Pohlemann T, Kappl R, Tschernig T.
Exp. Ther. Med. 2020 Nov;20(5):28. doi: 10.3892/etm.2020.9156. Epub 2020 Aug 31.

Integration of the B-Cell Receptor Antigen Neurabin-I/SAMD14 Into an Antibody Format as New Therapeutic Approach for the Treatment of Primary CNS Lymphoma.
Bewarder M, Kiefer M, Moelle C, Goerens L, Stilgenbauer S, Christofyllakis K, Kaddu-Mulindwa D, Fadle N, Regitz E, Neumann F, Hoth M, Preuss KD, Pfreundschuh M, Thurner L.
Front Oncol. 2020 Nov 12;10:580364. doi: 10.3389/fonc.2020.580364. eCollection 2020. PMID: 33282736 Free PMC article.

Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry.
Gibhardt CS, Cappello S, Bhardwaj R, Schober R, Kirsch SA, Bonilla Del Rio Z, Gahbauer S, Bochicchio A, Sumanska M, Ickes C, Stejerean-Todoran I, Mitkovski M, Alansary D, Zhang X, Revazian A, Fahrner M, Lunz V, Frischauf I, Luo T, Ezerina D, Messens J, Belousov VV, Hoth M, Böckmann RA, Hediger MA, Schindl R, Bogeski I.
Cell Rep. 2020 Oct 20;33(3):108292. doi : 10.1016/j.celrep.2020.108292.

Mechanoradicals in tensed tendon collagen as a source of oxidative stress.
Zapp C, Obarska-Kosinska A, Rennekamp B, Kurth M, Hudson DM, Mercadante D, Barayeu U, Dick TP, Denysenkov V, Prisner T, Bennati M, Daday C, Kappl R, Gräter F.
Nat Commun. 2020 May 8;11(1):2315. doi: 10.1038/s41467-020-15567-4.

CaMKII does not control mitochondrial Ca2+ uptake in cardiac myocytes.
Nickel AG, Kohlhaas M, Bertero E, Wilhelm D, Wagner M, Sequeira V, Kreusser MM, Dewenter M, Kappl R, Hoth M, Dudek J, Backs J, Maack C.
J Physiol. 2020 Apr;598(7):1361-1376. doi: 10.1113/JP276766. Epub 2019 Mar 27.

ARRB1-Promoted NOTCH1 Degradation Is Suppressed by OncomiR miR-223 in T-cell Acute Lymphoblastic Leukemia.
Shu Y, Wang Y, Lv WQ, Peng DY, Li J, Zhang H, Jiang GJ, Yang BJ, Liu S, Zhang J, Chen YH, Tang S, Wan KX, Yuan JT, Guo W, Fu G, Qi XK, Liu ZD, Liu HY, Yang C, Zhang LH, Liu FJ, Yu J, Zhang PH, Qu B, Zhao H, He TC, Zou L.
Cancer Res. 2020 Mar 1;80(5):988-998. doi: 10.1158/0008-5472.CAN-19-1471. Epub 2019 Dec 10

Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8+ T cells of elderly mice.
Angenendt A, Steiner R, Knörck A, Schwär G, Konrad M, Krause E, Lis A.
Aging (Albany NY). 2020 Feb 12;12(4):3266-3288. doi: 10.18632/aging.102809. Epub 2020 Feb 12.

Deterministic actin waves as generators of cell polarization cues.
Stankevicins L, Ecker N, Terriac E, Maiuri P, Schoppmeyer R, Vargas P, Lennon-Duménil AM, Piel M, Qu B, Hoth M, Kruse K, Lautenschläger F.
PNAS. 2020 Jan 14;117(2):826-835; first published December 27, 2019. doi :10.1073/pnas.1907845117

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Publications 2019

Monitoring kinetics reveals critical parameters of IgA-dependent granulocyte-mediated anti-tumor cell cytotoxicity.
Zwick A, Bernhard M, Knoerck A, Linxweiler M, Schick B, Heinzelmann J, Smola S, Lohse S.
Journal of Immunological Methods. 2019 Oct;473. doi: 10.1016/j.jim.2019.112644

Redox signals at the ER-mitochondria interface control melanoma progression.
Zhang X, Gibhardt CS, Will T, Stanisz H, Körbel C, Mitkovski M, Stejerean I, Cappello S, Pacheu-Grau D, Dudek J, Tahbaz N, Mina L, Simmen T, Laschke MW, Menger MD, Schön MP, Helms V, Niemeyer BA, Rehling P, Vultur A, Bogeski
I.  EMBO J. 2019 Aug 1;38(15):e100871. doi: 10.15252/embj.2018100871. Epub 2019 Jul 15.

IL-17C-mediated innate inflammation decreases the response to PD-1 blockade in a model of Kras-driven lung cancer.
Ritzmann F, Jungnickel C, Vella G, Kamyschnikow A, Herr C, Li D, Menger MM, Angenendt A, Hoth M, Lis A, Bals R, Beisswenger C.
Sci Rep. 2019 Jul 17;9(1):10353. doi: 10.1038/s41598-019-46759-8.

Reaction-diffusion model for STIM-ORAI interaction: The role of ROS and mutations.
Schmidt B, Alansary D, Bogeski I, Niemeyer BA, Rieger H.
Journal Of Theoretical Biology. 2019 Jun 7;470:64-75. doi: 10.1016/j.jtbi.2019.02.010

The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia.
Angenendt L, Bormann E, Pabst C, Alla V, Görlich D, Braun L, Dohlich K, Schwöppe C, Bohlander SK, Arteaga MF, Wethmar K, Hartmann W, Angenendt A, Kessler T, Mesters RM, Stelljes M, Rothenberg-Thurley M, Spiekermann K, Hébert J, Sauvageau G, Valk PJM, Löwenberg B, Serve H, Müller-Tidow C, Lenz G, Wörmann BJ, Sauerland MC, Hiddemann W, Berdel WE, Krug U, Metzeler KH, Mikesch JH, Herold T, Schliemann C.
Leukemia 33, 2830–2841 (2019). doi.org/10.1038/s41375-019-0505-x

Review-Quantification of Hydrogen Peroxide by Electrochemical Methods and Electron Spin Resonance Spectroscopy
Gulaboski R, Mirceski V, Kappl R, Hoth M, Bozem M.
Journal of The Electrochemical Society. 2019 May 23;166(8):G81-G101

STIM-Orai Channels and Reactive Oxygen Species in the Tumor Microenvironment.
Frisch J, Angenendt A, Hoth M, Prates Roma L, Lis A.
Cancers (Basel). 2019 Mar 30;11(4). pii: E457. doi: 10.3390/cancers11040457. Review.

A cancer-testis non-coding RNA LIN28B-AS1 activates driver gene LIN28B by interacting with IGF2BP1 in lung adenocarcinoma.
Wang C, Gu Y, Zhang E, Zhang K, Qin N, Dai J, Zhu M, Liu J, Xie K, Jiang Y, Guo X, Liu M, Jin G, Ma H, Jiang T, Yin R, Xia Y, Liu L, Wang S, Shen B, Huo R, Xu L, Sha J, Qu B, Shen H, Hu Z.
Oncogene 38. 2019 Mar 07;1611-1624. doi: 10.1038/s41388-018-0548-x

Macrophage Polarization is Deregulated in Haemophilia.
Knowles LM, Kagiri D, Bernard M, Schwarz EC, Eichler H, Pilch J.
Thromb Haemost. 2019 Feb;119(2):234-245. doi: 10.1055/s-0038-1676796. Epub 2019 Jan 16.

CaMKII does not control mitochondrial Ca2+ uptake in cardiac myocytes.
Nickel AG, Kohlhaas M, Bertero E, Wilhelm D, Wagner M, Sequeira V, Kreusser MM, Dewenter M, Kappl R, Hoth M, Dudek J, Backs J, Maack C.
J Physiol. 2019 Feb 16. doi: 10.1113/JP276766. [Epub ahead of print]

The histone demethylase PHF8 facilitates alternative splicing of the histocompatibility antigen HLA-G.
Leisegang MS, Gu L, Preussner J, Günther S, Hitzel J, Ratiu C, Weigert A, Chen W, Schwarz EC, Looso M, Fork C, Brandes RP.
Febs Letters. 2019 Feb 13; 539(5):487-498. doi: 10.1002/1873-3468.13337

miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling.
Hart M, Walch-Rückheim B, Friedmann KS, Rheinheimer S, Tänzer T, Glombitza B, Sester M, Lenhof HP, Hoth M, Schwarz EC, Keller A, Meese E.
Cell Death Dis. 2019 Jan 18;10(2):46. doi: 10.1038/s41419-018-1295-1.

Calcium signal dynamics in T lymphocytes: Comparing in vivo and in vitro measurements.
Friedmann KS, Bozem M, Hoth M.
Semin Cell Dev Biol. 2019 Jan 10. pii: S1084-9521(18)30055-7. doi: 10.1016/j.semcdb.2019.01.004. [Epub ahead of print] Review. PMID:  30630031

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Publications 2018

The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins.
Suzuki S, Lis A, Schmitz C, Penner R, Fleig A.
Cell Mol Life Sci. 2018 Aug;75(16):3069-3078. doi: 10.1007/s00018-018-2786-z. Epub 2018 Mar 2. 7,014 Impact Points.

Ca2+-dependent regulation and binding of calmodulin to multiple sites of Transient Receptor Potential Melastatin 3 (TRPM3) ion channels.
Przibilla J, Dembla S, Rizun O, Lis A, Jung M, Oberwinkler J, Beck A, Philipp SE
Cell Calcium 2018 Jul;73:40-52. doi: 10.1016/j.ceca.2018.03.005. Epub 2018 Mar 31. 3,932 Impact Points.

Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification, and modulation of apoptosis, necrosis, and mixed forms.
Backes CS, Friedmann KS, Mang S, Knörck A, Hoth M, Kummerow C.
J Biol Chem. 2018 Oct 19;293(42):16348-16363. doi: 10.1074/jbc.RA118.004549. Epub 2018 Sep 6.

AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticulum.
Klein MC, Zimmermann K, Schorr S, Landini M, Klemens PAW, Altensell J, Jung M, Krause E, Nguyen D, Helms V, Rettig J, Fecher-Trost C, Cavalié A, Hoth M, Bogeski I, Neuhaus HE, Zimmermann R, Lang S, Haferkamp I.
Nat Commun. 2018 Aug 28;9(1):3489. doi: 10.1038/s41467-018-06003-9.

Electrochemical quantification of extracellular local H2O2 kinetics originating from single cells.
Bozem M, Knapp P, Mirceski V, Slowik EJ, Bogeski I, Kappl R, Heinemann C, Hoth M.
Anitoxid Redox Signal. 2018 Aug 18;29(6):.

Light-sheet Microscopy for Three-dimensional Visualization of Human Immune Cells.
Schoppmeyer R, Zhao R, Hoth M, Qu B.
J Vis Exp. 2018 Jun 13;(136). doi: 10.3791/57651.

Quantity, quality, and functionality of peripheral blood cells derived from residual blood of different apheresis kits.
Knörck A, Marx S, Friedmann KS, Zöphel S, Lieblang L, Hässig C, Müller I, Pilch J, Sester U, Hoth M, Eichler H, Sester M, Schwarz EC.
Transfusion. 2018 Jun;58(6):1516-1526. doi: 10.1111/trf.14616. Epub 2018 May 6.

A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity.
Zhou X, Friedmann KS, Lyrmann H, Zhou Y, Schoppmeyer R, Knörck A, Mang S, Hoxha C, Angenendt A, Backes CS, Mangerich C, Zhao R, Cappello S, Schwär G, Hässig C, Neef M, Bufe B, Zufall F, Kruse K, Niemeyer BA, Lis A, Qu B, Kummerow C, Schwarz EC, Hoth M.
J Physiol. 2018 Jan 25. doi: 10.1113/JP274964. [Epub ahead of print]

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Publications 2017

NFATc1 controls the cytotoxicity of CD8+ T cells.
Klein-Hessling S, Muhammad K, Klein M, Pusch T, Rudolf R, Flöter J, Qureischi M, Beilhack A, Vaeth M, Kummerow C, Backes C, Schoppmeyer R, Hahn U, Hoth M, Bopp T, Berberich-Siebelt F, Patra A, Avots A, Müller N, Schulze A, Serfling E.
Nat Commun. 2017 Sep 11;8(1):511. doi: 10.1038/s41467-017-00612-6.

Human profilin 1 is a negative regulator of CTL mediated cell-killing and migration.
Schoppmeyer R, Zhao R, Cheng H, Hamed M, Liu C, Zhou X, Schwarz EC, Zhou Y, Knörck A, Schwär G, Ji S, Liu L, Long J, Helms V, Hoth M, Yu X, Qu B.
Eur J Immunol. 2017 Sep;47(9):1562-1572. doi: 10.1002/eji.201747124. Epub 2017 Jul 31.

Bystander cells enhance NK cytotoxic efficiency by reducing search time.
Zhou X, Zhao R, Schwarz K, Mangeat M, Schwarz EC, Hamed M, Bogeski I, Helms V, Rieger H, Qu B.
Sci Rep. 2017 Mar 13;7:44357. doi: 10.1038/srep44357

Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy.
Stapel B, Kohlhaas M, Ricke-Hoch M, Haghikia A, Erschow S, Knuuti J, Silvola JM, Roivainen A, Saraste A, Nickel AG, Saar JA, Sieve I, Pietzsch S, Müller M, Bogeski I, Kappl R, Jauhiainen M, Thackeray JT, Scherr M, Bengel FM, Hagl C, Tudorache I, Bauersachs J, Maack C, Hilfiker-Kleiner D.
Eur Heart J. 2017 Feb 1;38(5):349-361.

The extracellular adherence protein (Eap) of Staphylococcus aureus acts as a proliferation and migration repressing factor that alters the cell morphology of keratinocytes.
Eisenbeis J, Peisker H, Backes CS, Bur S, Hölters S, Thewes N, Greiner M, Junker C, Schwarz EC, Hoth M, Junker K, Preissner KT, Jacobs K, Herrmann M, Bischoff M.
Int J Med Microbiol. 2017 Jan 18. pii: S1438-4221(17)30026-7. doi: 10.1016/j.ijmm.2017.01.002. [Epub ahead of print]

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Publications 2016

Cytoskeleton rotation relocates mitochondria to the immunological synapse and increases calcium signals.
Maccari I, Zhao R, Peglow M, Schwarz K, Hornak I, Pasche M, Quintana A, Hoth M, Qu B, Rieger H.
Cell Calcium. 2016 Nov;60(5):309-321. doi: 10.1016/j.ceca.2016.06.007.

New insights into the chemistry of Coenzyme Q-0: A voltammetric and spectroscopic study.
Gulaboski R, Bogeski I, Kokoskarova P, Haeri HH, Mitrev S, Stefova M, Stanoeva JP, Markovski V, Mirčeski V, Hoth M, Kappl R.
Bioelectrochemistry. 2016 Oct;111:100-8. doi: 10.1016/j.bioelechem.2016.05.008

DNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA.
Tang Q, Holland-Letz T, Slynko A, Cuk K, Marme F, Schott S, Heil J, Qu B, Golatta M, Bewerunge-Hudler M, Sutter C, Surowy H, Wappenschmidt B, Schmutzler R, Hoth M, Bugert P, Bartram CR, Sohn C, Schneeweiss A, Yang R, Burwinkel B.
Oncotarget. 2016 Sep 27;7(39):64191-64202. doi: 10.18632/oncotarget.11640.

Thiol dependent intramolecular locking of Orai1 channels.
Alansary D, Schmidt B, Dörr K, Bogeski I, Rieger H, Kless A, Niemeyer BA.
Sci Rep. 2016 Sep 14;6:33347. doi: 10.1038/srep33347.

Imaging calcium and redox signals using genetically encoded fluorescent indicators.
Gibhardt CS, Zimmermann KM, Zhang X, Belousov VV, Bogeski I.
Cell Calcium. 2016 Aug;60(2):55-64. doi: 10.1016/j.ceca.2016.04.008. Review.

Optimality of Spatially Inhomogeneous Search Strategies.
Schwarz K, Schröder Y, Qu B, Hoth M, Rieger H.
Phys Rev Lett. 2016 Aug 5;117(6):068101. doi: 10.1103/PhysRevLett.117.068101.

Plant sterol ester diet supplementation increases serum plant sterols and markers of cholesterol synthesis, but has no effect on total cholesterol levels.
Weingärtner O, Bogeski I, Kummerow C, Schirmer SH, Husche C, Vanmierlo T, Wagenpfeil G, Hoth M, Böhm M, Lütjohann D, Laufs U.
J Steroid Biochem Mol Biol. 2016 Jul 27. pii: S0960-0760(16)30215-1. doi: 10.1016/j.jsbmb.2016.07.016. [Epub ahead of print]

Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes.
Bhat SS,Friedmann KS, Knörck, Hoxha C, Leidinger P, Backes C, Meese E, Keller A, Rettig J, Hoth M, Qu B, Schwarz EC.
Biochim Biophys Acta - Molecular Cell Research. 2016 Jul;Vol. 1863, Issue 7 Part A:pp 1653-1664

The role of Orai-STIM calcium channels in melanocytes and melanoma.
Stanisz H, Vultur A, Herlyn M, Roesch A, Bogeski I.
J Physiol. 2016 Jun 1;594(11):2825-35. doi: 10.1113/JP271141.

The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α.
AnnaTosatto, RobertaSommaggio, CarstenKummerow, Robert BBentham, Thomas SBlacker, TundeBerecz, Michael RDuchen, AntonioRosato, IvanBogeski, GyorgySzabadkai, RosarioRizzuto, CristinaMammucari
EMBO Molecular Medicine. 2016 April 01; Vol. 8, Issue 4:pp 305-436

An EPR and DFT study on the primary radical formed in hydroxylation reactions of 2,6-dimethoxy-1,4-benzoquinone.
Haeri H, Bogeski I, Gulaboski R, Mirceski V, Hoth M, Kappl R.
Mol Phys. 2016, March 17 online

A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.
Saul S, Gibhardt CS, Schmidt B, Lis A, Pasieka B, Conrad D, Jung P, Gaupp R, Wonnenberg B, Diler E, Stanisz H, Vogt T, Schwarz EC, Bischoff M, Herrmann M, Tschernig T, Kappl R, Rieger H, Niemeyer BA, Bogeski I.
Sci Signal. 2016 Mar 8;9(418):ra26.

Cell type-specific glycosylation of Orai1 modulates store-operated Ca2+ entry.
Dörr K, Kilch T, Kappel S, Alansary D, Schwär G, Niemeyer BA, Peinelt C.
Sci Signal. 2016 Mar 8;9(418):ra25.

Transit of H₂O₂ across the endoplasmic reticulum membrane is not sluggish.
Appenzeller-Herzog C, Bánhegyi G, Bogeski I, Davies KJ, Delaunay-Moisan A, Forman HJ, Görlach A, Kietzmann T, Laurindo F, Margittai E, Meyer AJ, Riemer J, Rützler M, Simmen T, Sitia R, Toledano MB, Touw IP.
Free Radic Biol Med. 2016 Feb 27;94:157-160. doi: 10.1016/j.freeradbiomed.2016.02.030. [Epub ahead of print]

Deep characterization of blood cell miRNomes by NGS.
Schwarz EC, Backes C, Knörck A, Ludwig N, Leidinger P, Hoxha C, Schwär G, Grossmann T, Müller SC, Hart M, Haas J, Galata V, Müller I, Fehlmann T, Eichler H, Franke A, Meder B, Meese E, Hoth M, Keller A.
Cell Mol Life Sci. 2016 Feb 13. [Epub ahead of print]

The role of Orai/STIM calcium channels in melanocytes and melanoma.
Stanisz H, Vultur A, Herlyn M, Roesch A, Bogeski I.
J Physiol. 2016 Feb 10. doi: 10.1113/JP271141. [Epub ahead of print]

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Publications 2015

A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca2+ permeation and SOCE-induced gene transcription.
Frischauf I, Zayats V, Deix M, Hochreiter A, Jardin I, Muik M, Lackner B, Svobodova B, Pammer T, Litvinukova M, Sridhar AA, Derler I, Bogeski I, Romanin C, Ettrich RH, Schindl R.
Sci. Signal. 22 Dec 2015; Vol. 8, Issue 408, pp. ra131

CRAC channels, calcium, and cancer in light of the driver and passenger concept.
Hoth M.
Biochim Biophys Acta. 2015 Dec 17. pii: S0167-4889(15)00430-9. [Epub ahead of print] Review.

A natural heme-signature variant of CYP267A1 from Sorangium cellulosum So ce56 executes diverse ω-hydroxylation.
Khatri Y, Hannemann F, Girhard M, Kappl R, Hutter M, Urlacher VB, Bernhardt R.
FEBS J. 2015 Oct 10. doi: 10.1111/febs.13104.

The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake.
Petrungaro C, Zimmermann KM, Küttner V, Fischer M, Dengjel J, Bogeski I, Riemer J.
Cell Metab. 2015 Oct 6;22(4):721-33. doi: 10.1016/j.cmet.2015.08.019.

Differential redox regulation of Ca2+ signaling and viability in normal and malignant prostate cells.
Holzmann C, Kilch T, Kappel S, Dörr K, Jung V, Stöckle M, Bogeski I, Peinelt C.
Biophysical Journal, 2015 Oct 6;109(7):1410-9.

Mitochondrial Ca2+ uptake is regulated by the Ca2+-dependent interaction of a disulfide-linked MICU1-MICU2 dimer which is formed by Mia40.
Petrungaro C, Zimmermann KM, Küttner V, Fischer M, Dengjel J, Bogeski I, Riemer J.
Cell Metabolism. 2015 Oct 6; 22(4):721-33.

Reversal of mitochondrial transhydrogenase causes oxidative stress in heart failure.
Nickel A, Hardenberg A, Hohl A, Löffler J, Kohlhaas M, Becker J, Reil J, Kazakov A, Bonnekoh J, Stadelmaier M, Puhl S, Wagner M, Bogeski I, Cortassa S, Kappl R, Pasieka B, Lafontaine M, Lancaster R, Blacker T, Hall A, Duchen M, Kästner L, Lipp P, Zeller T, Müller C, Knopp A, Laufs U, Böhm U, Hoth M, Maack C.
Cell Metab. 2015 Sep 1;22(3):472-84. doi: 10.1016/j.cmet.2015.07.008. Epub 2015 Aug 6.

VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity.
Marshall MR, Pattu V, Halimani M, Maier-Peuschel M, Müller ML, Becherer U, Hong W, Hoth M, Tschernig T, Bryceson YT, Rettig J.
J Cell Biol. 2015 Jul 6;210(1):135-51. doi: 10.1083/jcb.201411093. Epub 2015 Jun 29.

Human T cells monitored by impedance spectrometry using field-effect transistor arrays: a novel tool for single-cell adhesion and migration studies.
Law JK, Susloparova A, Vu XT, Zhou X, Hempel F, Qu B, Hoth M, Ingebrandt S.
Biosens Bioelectron. 2015 May 15;67:170-6. doi: 10.1016/j.bios.2014.08.007. Epub 2014 Aug 13.

Redox regulation of T-Cell Receptor signaling.
Simeoni L, Bogeski I.
Biol Chem. 2015 May;396(5):555-68. doi: 10.1515/hsz-2014-0312.

A STIM2 splice variant negatively regulates store-operated calcium entry.
Miederer AM, Alansary D, Schwär G, Lee PH, Jung M, Helms V, Niemeyer BA.
Nat Commun. 2015 Apr 21;6:6899. doi: 10.1038/ncomms7899.

DNA methylation array analyses identified breast cancer-associated HYAL2 methylation in peripheral blood.
Yang R, Pfütze K, Zucknick M, Sutter C, Wappenschmidt B, Marme F, Qu B, Cuk K, Engel C, Schott S, Schneeweiss A, Brenner H, Claus R, Plass C, Bugert P, Hoth M, Sohn C, Schmutzler R, Bartram CR, Burwinkel B.
Int J Cancer. 2015 Apr 15;136(8):1845-55. doi: 10.1002/ijc.29205. Epub 2014 Sep 24.

Influence of extracellular magnesium on phagocytosis and free cytosolic Mg levels in differentiated U937 and MH-S cells.
Diler E, Saul S, Bogeski I, Meier C, Tschernig T.
Magnesium Research. 2015 Jan-Mar;28(1):23-31.

Facilitation of Orai3 targeting and store-operated function by Orai1.
Alansary D, Bogeski I, Niemeyer BA
.Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2015 Mar; 1853(7):1541-1550.

Mitochondrial oxidative stress as a novel therapeutic target to overcome intrinsic drug resistance in melanoma cell subpopulations.
Cierlitza M, Chauvistré H, Bogeski I, Zhang X, Hauschild A, Herlyn M, Schadendorf D, Vogt T, Roesch A.
Experimental Dermatology. 2015 Feb; 24(2):155-7. doi: 10.1111/exd.12613

Recognition of Bacterial Signal Peptides by Mammalian Formyl Peptide Receptors: A New Mechanism for Sensing Pathogens.
Bufe B, Schumann T, Kappl R, Bogeski I, Kummerow C, Podgorska M, Smola S, Hoth M, Zufall F.
Journal of Biological Chemistry. 2015; 20;290(12):7369-87.

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Publications 2014

Red fluorescent genetically encoded indicator for intracellular ​hydrogen peroxide.
Ermakova Y, Bilan D, Matlashov M, Mishina N, Markvicheva K, Subach O, Subach F, Bogeski I, Hoth M, Enikolopov G, Belousov V.
Nature Communications. 2014 Oct 21;5:5222. doi: 10.1038/ncomms6222.

A natural heme-signature variant of CYP267A1 from Sorangium cellulosum So ce56 executes diverse ω-hydroxylation.
Khatri Y, Hannemann F, Girhard M, Kappl R, Hutter M, Urlacher VB, Bernhardt R.
FEBS J. 2014 Oct 10. doi: 10.1111/febs.13104. [Epub ahead of print]

DNA methylation array analyses identified breast cancer-associated HYAL2 methylation in peripheral blood.
Yang R, Pfütze K, Zucknick M, Sutter C, Wappenschmidt B, Marme F, Qu B, Cuk K, Engel C, Schott S, Schneeweiss A, Brenner H, Claus R, Plass C, Bugert P, Hoth M, Sohn C, Schmutzler R, Bartram CR, Burwinkel B.
Int J Cancer. 2014 Sep 12. doi: 10.1002/ijc.29205. [Epub ahead of print]

Redox regulation of ion channels.
Bogeski I, Niemeyer BA.
Antioxid Redox Signal. 2014 Aug 20;21(6):859-62. doi: 10.1089/ars.2014.6019. Epub 2014 Jul 8.

Human T cells monitored by impedance spectrometry using field-effect transistor arrays: A novel tool for single-cell adhesion and migration studies.
Law JK, Susloparova A, Vu XT, Zhou X, Hempel F, Qu B, Hoth M, Ingebrandt S.
Biosens Bioelectron. 2014 Aug 13. pii: S0956-5663(14)00595-8. doi: 10.1016/j.bios.2014.08.007. [Epub ahead of print]

Patch-clamp measurement of ICRAC and ORAI channel activity.
Alansary D, Kilch T, Holzmann C, Peinelt C, Hoth M, Lis A.
Cold Spring Harb Protoc. 2014 Jun 2;2014(6):602-7. doi: 10.1101/pdb.top066795.

The minimal requirements to use calcium imaging to analyze ICRAC.
Alansary D, Kilch T, Holzmann C, Peinelt C, Hoth M, Lis A.
Cold Spring Harb Protoc. 2014 Jun 2;2014(6):638-42. doi: 10.1101/pdb.prot073262.

Measuring endogenous ICRAC and ORAI currents with the patch-clamp technique.
Alansary D, Kilch T, Holzmann C, Peinelt C, Hoth M, Lis A.
Cold Spring Harb Protoc. 2014 Jun 2;2014(6):630-7. doi: 10.1101/pdb.prot073254.

A simple, economic, time-resolved killing assay.
Kummerow C, Schwarz EC, Bufe B, Zufall F, Hoth M, Qu B.
Eur J Immunol. 2014 Jun;44(6):1870-2. doi: 10.1002/eji.201444518. Epub 2014 Apr 13. No abstract available.

Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry.
Stanisz H, Saul S, Müller CS, Kappl R, Niemeyer BA, Vogt T, Hoth M, Roesch A, Bogeski I.
Pigment Cell Melanoma Res. 2014 May;27(3):442-53. doi: 10.1111/pcmr.12222. Epub 2014 Mar 7.

How ORAI and TRP channels interfere with each other: interaction models and examples from the immune system and the skin.
Saul S, Stanisz H, Backes CS, Schwarz EC, Hoth M.
Eur J Pharmacol. 2014 Sep 15;739:49-59. doi: 10.1016/j.ejphar.2013.10.071. Epub 2013 Nov 28.

Substrate-assisted O2 activation in a cofactor-independent dioxygenase.
Thierbach S, Bui N, Zapp J, Chhabra SR, Kappl R, Fetzner S.
Chem Biol. 2014 Feb 20;21(2):217-25. doi: 10.1016/j.chembiol.2013.11.013. Epub 2014 Jan 2.

Syntaxin11 serves as a t-SNARE for the fusion of lytic granules in human cytotoxic T lymphocytes.
Halimani M, Pattu V, Marshall MR, Chang HF, Matti U, Jung M, Becherer U, Krause E, Hoth M, Schwarz EC, Rettig J.
Eur J Immunol. 2014 Feb;44(2):573-84. doi: 10.1002/eji.201344011. Epub 2013 Dec 16.

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Publications 2013

Square-Wave Voltammetry: A Review on the Recent Progress.
Mirceski V, Gulaboski R, Lovric M, Bogeski I, Kappl R, Hoth M.
Electroanalysis. 2013 Nov;25(11):2411-2422.

ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer.
Holzmann C, Kilch T, Kappel S, Armbrüster A, Jung V, Stöckle M, Bogeski I, Schwarz EC, Peinelt C.
Oncotarget. 2013 Nov;4(11):2096-107.

Molecular regulation of CRAC channels and their role in lymphocyte function.
Shaw PJ, Qu B, Hoth M, Feske S.
Cell Mol Life Sci. 2013 Aug;70(15):2637-56. Epub 2012 Oct 5.

Calcium, cancer and killing: the role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells.
Schwarz EC, Qu B, Hoth M.
Biochim Biophys Acta. 2013 Jul;1833(7):1603-11. Epub 2012 Dec 3. Review.

Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes.
Dudenhöffer-Pfeifer M, Schirra C, Pattu V, Halimani M, Maier-Peuschel M, Marshall MR, Matti U, Becherer U, Dirks J, Jung M, Lipp P, Hoth M, Sester M, Krause E, Rettig J.
Traffic. 2013 Jul;14(7):798-809.

Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells.
Roesch A, Vultur A, Bogeski I, Wang H, Zimmermann KM, Speicher D, Körbel C, Laschke MW, Gimotty PA, Philipp SE, Krause E, Pätzold S, Villanueva J, Krepler C, Fukunaga-Kalabis M, Hoth M, Bastian BC, Vogt T, Herlyn M.
Cancer Cell. 2013 Jun 10;23(6):811-25

Hydroxylated derivatives of dimethoxy-1,4-benzoquinone as redox switchable earth-alkaline metal ligands and radical scavengers.
Gulaboski R, Bogeski I, Mirčeski V, Saul S, Pasieka B, Haeri HH, Stefova M, Stanoeva JP, Mitrev S, Hoth M, Kappl R.
Sci Rep. 2013 May;3:1865.

Profilin1 potentiates apoptosis induced by staurosporine in cancer cells.
Yao W, Cai X, Liu C, Qin Y, Cheng H, Ji S, Xu W, Wu C, Chen T, Xu J, Long J, Fang Z, Qu B, Hoth M, Ni Q, Zha X, Yu X.
Curr Mol Med. 2013 Mar;13(3):417-28.

ORMDL3 modulates store-operated calcium entry and lymphocytes activation.
Carreras-Sureda A, Cantero-Recasens G, Rubio-Moscardo F, Kiefer K, Peinelt C, Niemeyer BA
Hum Mol Genet 2013 Feb;22(3):519-30.

The Neglected CRAC Proteins: Orai2, Orai3, and STIM2.
Hoth M, Niemeyer BA.
Curr Top Membr. 2013;71:237-71.

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Publications 2012

Mutations of the Ca²⁺-sensing Stromal Interaction Molecule STIM1 regulate Ca²⁺ influx by altered oligomerization of STIM1 and by destabilization of the Ca²⁺ channel Orai1
Kilch T, Alansary D, Peglow M, Doerr K, Rychkov G, Rieger H, Peinelt C, Niemeyer BA.
Journal of Biological Chemistry. 2012 Dec 04

ROS and SOCE: recent advances and controversies in the regulation of STIM and Orai.
Bogeski I, Kilch T, Niemeyer BA.
J Physiol. 2012 Sep 1;590(Pt 17):4193-200. doi: 10.1113/jphysiol.2012.230565. Epub 2012 May 21.

Protein film voltammetry: electrochemical enzymatic spectroscopy. A review on recent progress
Gulaboski R, Mirceski V, Bogeski I, Hoth M.
Journal Of Solid State Electrochemistry. 2012 Jul,16(7,SI):2315-2328. doi: 10.1007/s10008-011-1397-5

Calcium, cancer and killing: The role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells.
Schwarz EC, Qu B, Hoth M.
Biochim Biophys Acta. 2012 Dec 3. doi:pii: S0167-4889(12)00348-5. 10.1016/j.bbamcr.2012.11.016. [Epub ahead of print]

Molecular regulation of CRAC channels and their role in lymphocyte function.
Shaw PJ, Qu B, Hoth M, Feske S.
Cell Mol Life Sci. 2012 Oct 5. [Epub ahead of print]

Can we see PIP(3) and hydrogen peroxide with a single probe?
Mishina NM, Bogeski I, Bolotin DA, Hoth M, Niemeyer BA, Schultz C, Zagaynova EV, Lukyanov S, Belousov VV.
Antioxid Redox Signal. 2012 Aug 1;17(3):505-12. doi: 10.1089/ars.2012.4574. Epub 2012 Apr 10.

Mitochondrial dynamics and their impact on T cell function.
Quintana A, Hoth M.
Cell Calcium. 2012 Jul;52(1):57-63. doi: 10.1016/j.ceca.2012.02.005. Epub 2012 Mar 14. Review.

ORAI1 Ca(2+) channels control endothelin-1-induced mitogenesis and melanogenesis in primary human melanocytes.
Stanisz H, Stark A, Kilch T, Schwarz EC, Müller CS, Peinelt C, Hoth M, Niemeyer BA, Vogt T, Bogeski I.
Journal of Investigative Dermatology. 2012 May; 132(5): 1443–1451.

Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis.
Schirmer SH, Degen A, Baumhakel M, Custodis F, Schuh L, Kohlhaas M, Friedrich E, Bahlmann F, Kappl R, Maack C, Bohm M, Laufs U.
Eur Heart J. 2012 May;33(10):1223-31.

SNARE protein expression and localization in human cytotoxic T lymphocytes.
Pattu V, Qu B, Schwarz EC, Strauβ B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M.
Eur J Immunol. 2012 Feb;42(2):470-5. doi: 10.1002/eji.201141915. Epub 2012 Jan 5.

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Publications 2011

Determination of copper(II) ion concentration by lifetime measurements of green fluorescent protein.
Hotzer B, Ivanov R, Altmeier S, Kappl R, Jung G.
J Fluoresc. 2011 Nov;21(6):2143-53.

Excitable T cells: Ca(v)1.4 channel contributions and controversies.
Niemeyer BA, Hoth M.
Immunity. 2011 Sep 23;35(3):315-7.

Redox regulation of calcium ion channels: chemical and physiological aspects.
Bogeski I, Kappl R, Kummerow C, Gulaboski R, Hoth M, Niemeyer BA.
Cell Calcium. 2011 Nov;50(5):407-23. doi: 10.1016/j.ceca.2011.07.006. Epub 2011 Sep 17.

ISC-like [2Fe-2S] ferredoxin (FdxB) dimer from Pseudomonas putida JCM 20004: structural and electron-nuclear double resonance characterization.
Iwasaki T, Kappl R, Bracic G, Shimizu N, Ohmori D, Kumasaka T.
J Biol Inorg Chem. 2011 Aug;16(6):923-35. doi: 10.1007/s00775-011-0793-8. Epub 2011 Jun 7.

Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation.
Quintana A, Pasche M, Junker C, Al-Ansary D, Rieger H, Kummerow C, Nuñez L, Villalobos C, Meraner P, Becherer U, Rettig J, Niemeyer BA, Hoth M.
The EMBO Journal advance online publication 16 August 2011; doi:10.1038/emboj.2011.289 Published online: 16 August 2011

Structural and thermodynamic characterization of the adrenodoxin-like domain of the electron-transfer protein Etp1 from Schizosaccharomyces pombe.
Müller JJ, Hannemann F, Schiffler B, Ewen KM, Kappl R, Heinemann U, Bernhardt R.
J Inorg Biochem. 2011 Jul;105(7):957-65. doi: 10.1016/j.jinorgbio.2011.04.001. Epub 2011 Apr 9.

Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes.
Pattu V, Qu B, Marshall M, Becherer U, Junker C, Matti U, Schwarz EC, Krause E, Hoth M, Rettig J.
Traffic. 2011 Jul;12(7):890-901. doi: 10.1111/j.1600-0854.2011.01193.x. Epub 2011 Apr 21.

Calcium binding and transport by coenzyme q.
Bogeski I, Gulaboski R, Kappl R, Mirceski V, Stefova M, Petreska J, Hoth M.
J Am Chem Soc. 2011 Jun 22;133(24):9293-303. Epub 2011 May 24.

Docking of Lytic Granules at the Immunological Synapse in Human CTL Requires Vti1b-Dependent Pairing with CD3 Endosomes.
Qu B, Pattu V, Junker C, Schwarz EC, Bhat SS, Kummerow C, Marshall M, Matti U, Neumann F, Pfreundschuh M, Becherer U, Rieger H, Rettig J, Hoth M.
J Immunol. 2011 Jun 15;186(12):6894-904. Epub 2011 May 11.

ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance.
Qu B, Al-Ansary D, Kummerow C, Hoth M, Schwarz EC.
Cell Calcium. 2011 Jun 10. [Epub ahead of print]

Nonsteroidal Anti-inflammatory Drugs Inhibit Vascular Smooth Muscle Cell Proliferation by Enabling the Ca2+-dependent Inactivation of Calcium Release-activated Calcium/Orai Channels Normally Prevented by Mitochondria.
Muñoz E, Valero RA, Quintana A, Hoth M, Núñez L, Villalobos C.
J Biol Chem. 2011 May 6;286(18):16186-96. Epub 2011 Mar 14.

Immune synapses: mitochondrial morphology matters.
Junker C, Hoth M.
EMBO J. 2011 Apr 6;30(7):1187-9. Review. No abstract available.

TRP expression pattern and the functional importance of TRPC3 in primary human T-cells.
Wenning AS, Neblung K, Strauß B, Wolfs MJ, Sappok A, Hoth M, Schwarz EC.
Biochim Biophys Acta. (2011 Mar);1813(3):412-23. Epub 2011 Jan 4.

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Publications 2010

Thapsigargin induces expression of activating transcription factor 3 in human keratinocytes involving Ca2+ ions and c-Jun N-terminal protein kinase.
Spohn D, Rössler OG, Philipp SE, Raubuch M, Kitajima S, Griesemer D, Hoth M, Thiel G.
Mol Pharmacol. (2010 Nov);78(5):865-76. Epub 2010 Aug 16.

Pharmacology of ORAI channels as a tool to understand their physiological functions.
Bogeski I, Al-Ansary D, Qu B, Niemeyer BA, Hoth M, Peinelt C.
Expert Review of Clinical Pharmacology (2010 May);3 (3):291-303.

Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling.
Bogeski I, Kummerov C, Al-Ansary D, Schwarz EC, Koehler R, Kozai D, Takahashi N, Peinelt C, Griesemer D, Bozem M, Mori Y, Hoth M, Niemeyer BA.
Sci Signal. (2010 Mar 30);3 (115):ra24.

Mitochondria positioning controls local calcium influx in T cells.
Schwindling C, Quintana A, Krause E, Hoth M.
J Immunol (2010 Jan);184(1):184-90. Epub 2009 Nov 30.

Efficiency of T-cell co-stimulation by CD80 and CD86 cross-linking correlates with calcium entry.
Thiel M, Wolfs M-J, Bauer S, Wenning AS, Burckhart T, Schwarz EC, Scott AM, Renner C, Hoth M.
Immunology (2010 Jan);129(1):28-40. Epub 2009 Oct 12.

ATP modulates Ca2+ uptake by TRPV6 and is counteracted by isoform-specific phosphorylation.
Al-Ansary D, Bogeski I, Disteldorf BM, Becherer U, Niemeyer BA.
FASEB J. (2010 Feb);24(2):425-35. Epub 2009 Oct 5.

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Publications 2009

The immunological synapse controls local and global calcium signals in T lymphocytes.
Kummerow C, Junker C, Kruse K, Rieger H, Quintana A, Hoth M.
Immunol. Rev. (2009 Sep);231(1):132-147

Morphological changes of T cells following formation of immunological synapse modulate intracellular calcium signals.
Quintana A, Kummerow C, Junker C, Becherer U, Hoth M.
Cell calcium (2009 Feb);45(2):109-122

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Publications 2008

A new rapid and simple method to determine the kinetics of electrode reactions of biologically relevant compounds from half-peak width of the square-wave voltammograms.
Gulaboski R, Lovric M, Mirceski V, Bogeski I, Hoth M.
Biophys. Chem. (2008 Dec);138(3):130-137

Quercetinase QueD of Streptomyces sp FLA, a Monocupin Dioxygenase with a Preference for Nickel and Cobalt.
Merkens H, Kappl R, Jakob RP, Schmid FX, Fetzner S
Biochemistry. 2008 Nov 12;47(46):12185-12196.

Protein-film voltammetry: A theoretical study of the temperature effect using square-wave voltammetry.
Gulaboski R, Lovric M, Mirceski V, Bogeski I, Hoth M.
Biophys. Chem. (2008 Sep);137(1):49-55

Redox properties of the calcium chelator Fura-2 in mimetic biomembranes.
Gulaboski R, Pereira CM, Cordeiro MN, Silva AF, Hoth M, Bogeski I.
Cell Calcium (2008 June);43(2):615-621

Probing the redox activity of T-lymphocytes deposited at electrode surfaces with voltammetric methods.
Bogeski I, Mirceski V, Hoth M.
Clin. Chem. Lab. Med. (2008 Feb);46(2):197-203
Five chapters of the Duale Reihe "Physiologie", Allgemeine Einführung, Neurophysiologie, Blut, Immunsystem, Herz.
(2008 in press)

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Publications 2007

Calcium dependence of T-cell proliferation following focal stimulation.
Schwarz EC, Kummerow C, Wennings AS, Wagner K, Waggershauser K, Griesemer D, Staruß B, Wolfs M-J, Quintana A, Hoth M.
Eur. J. Immunol. (2007 Sep 26);37(10):2723-2733

T cell activation requires mitochondrial translocation to the immunological synapse.
Quintana A, Schwindling C, Wenning AS, Becherer U, Rettig J, Schwarz EC, Hoth M.
Proc. Natl. Acad. Sci. USA. (2007 Sep 4);104(36):14418-14423

Disruption of the cortical actin cytoskeleton does not affect store operated Ca²⁺ channels in human T-cells.
Mueller P, Quintana A, Griesemer D, Hoth M, Pieters J.
FEBS lett. (2007 July 24);581(18):3557-3562

P2X(7) receptor stimulation upregulates Egr-1 biosynthesis involving a cytosolic Ca²⁺ rise, transactivation of the EGF receptor and phosphorylation of ERK and Elk-1.
Stefano L, Rössler OG, Griesemer D, Hoth M, Thiel G.
J. Cell. Physiol. (2007 May 1);213(1):36-44

Redox chemistry of Ca-transporter 2-palmitoylhydroquinone in an artificial thin organic film membrane.
Mirceski V, Gulaboski R, Bogeski I, Hoth M.
J. Phys. Chem. (2007 Mar 29);111(16):6068-6076

Evaluation of the lipophilic properties of opioids, amphetamine-like drugs, and metabolites through electrochemical studies at the interface between two immiscible solutions.
Gulaboski R, Cordeiro MN, Milhazes N, Garrido J, Borges F, Jorge M, Pereira CM, Bogeski I, Morales AH, Naumoski B, Silva AF.
Analytical Biochemistry. 2007 Feb 15;361(2):236-243

TRP channels in lymphocytes.
Schwarz EC, Wolfs MJ, Tonner S, Wenning A, Quintana A, Griesemer D, Hoth M.
Handb. Exp. Pharmacol. (2007 Feb);179:445-456

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Publications 2006

Sustained activity of CRAC channels requires translocation of mitochondria to the plasma membrane.
Quintana A, Schwarz EC, Schwindling C, Lipp P, Kaestner L, Hoth M.
J. Biol. Chem. (2006 Dec 29);281:40302-40309

CRAC calcium channels as signal transducers in T-cells.
Griesemer D, Löffler B, Kummerow C, Quintana A, Schwarz EC, Hoth M.
Signal Transduction (2006 July 11);6(4):233-239

TRPV6 potentiates calcium-dependent cell proliferation.
Schwarz EC, Wissenbach U, Niemeyer BA, Strauß B, Philipp SE, Flockerzi V, Hoth M.
Cell Calcium (2006 Feb);39(2):163-173

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Publications 2005

Calcium-dependent activation of T-lymphoctes.
Quintana A, Griesemer D, Schwarz EC, Hoth M.
Eur. J. Physiol. Pflügers Arch. (2005 April);450(1):1-12

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Publications 2004

Two-photon analysis of calcium signals in T-lymphocytes of intact human intestine.
Tutsch E, Griesemer D, Schwarz A, Stallmach A, Hoth M.
Eur. J. Immunol. (2004 Sep 20);34(12):3477-3484

Apparent cytosolic calcium gradients in T-lymphocytes and other cell types due to fura-2 accumulation in mitochondra.
Quintana A, Hoth M.
Cell Calcium (2004 Aug);36(2):99-109

Potent inhibition of CRAC channels and T-lymphocyte activation by the pyrazole derivative BTP2.
Zitt C, Strauß B, Schwarz EC, Spaeth N, Hatzelmann A, Hoth M.
J. Biol. Chem. (2004 Mar 26);279:12427-12437

Ca²⁺ signaling in identified lymphocytes from human intestine: relation to hyporeactivity, proliferation and inflammatory bowel disease.
Schwarz A, Tutsch E, Ludwig B, Schwarz EC, Stallmach A, Hoth M.
J. Biol. Chem. (2004 Feb 13);279:5641-5647

Calcium transport in T-lymphocytes.
Griesemer D, Quintana A, Mery L, Schwarz E, Hoth M.
Nova Acta Leopoldina (2004);89(336):75-80

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Publications 2003

TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes.
Philipp S, Strauß B, Hirnet D, Mery L, Wissenbach U, Flockerzi V, Hoth M.
J. Biol. Chem. (2003 July 18);278:26629-26638

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Publications 2002

Enhancement of calcium signalling dynamics and stability by delayed modulation of the plasma-membrane calcium-ATPase in human T-cells.
Bautista DM, Hoth M, Lewis RS.
J Physiol. (2002 June 15);541(3):877-894

The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells.
Mery L, Strauß B, Dufour JF, Krause KH, Hoth M.
J. Cell Science (2002 June 14);115:3497-3508

Skeletal muscle L-type ca²⁺ current modulation in γ1-deficient and wildtype murine myotubes by the γ1 subunit and cAMP.
Held B, Freise D, Freichel M, Hoth M, Flockerzi V.
J Physiol. (2002 Jan 11);539(2):459-468

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Publications 2001

Ion channels in health and disease.
Niemeyer BA, Mery L, Zawar C, Suckow A, Monje F, Pardo LA, Stühmer W, Flockerzi V, Hoth M.
EMBO Reports (2001);2(7):568-573

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Publications 2000

Mitochondrial control of calcium-channel gating: A mechanism for sustained signaling and transcriptional activation in T lymphocytes.
Hoth M, Button DC, Lewis RS.
Proc. Natl. Acad. Sci. USA. 2000 Sep 12;97(19):10607-10612

TRP4 (CCE1)protein is part of native calcium release-activated Ca²⁺-like channels in adrenal cells.
Philipp S, Trost C, Warnat J, Rautmann J, Himmerkus N, Schroth G, Kretz O, Nastainczyk W, Cavalie A, Hoth M, Flockerzi V.
J. Biol. Chem. 2000 May 17;275:23965-23972

Absence of the γ subunit of the skeletal muscle dihydropyridine receptor increases L-type Ca²⁺ currents and alters channel inactivation properties.
Freise D, Held B, Wissenbach U, Pfeifer A, Trost C, Himmerkus N, Schweig U, Freichel M, Biel M, Hofmann F, Hoth M, Flockerzi V.
J. Biol. Chem. 2000 May 12;275:14476-14481

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Publications 1999

Monitoring intra-mitochondrial calcium concentration with rhod-2.
Hoth M, Lewis RS.
In "Imaging Neurones", eds. Yuste R, LAnni F, Konnerth A, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, (1999);pp 39.1-39.14

Simultanous measurements of membrane current and intracellular calcium.
Zweifach A, Hoth M, Lewis RS.
In "Advanced Imaging Techniques", eds. Fasolato C, Rizzuto R, Springer Verlag, Hamburg, (1999)

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Publications 1998

The fate of calcium ions entering a cell.
Hoth M.
In "Integrative Aspects of Calcium Signaling", eds. Verkhratsky A & Toescu E, Plenum Press, New York, (1998);pp 23-33

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Publications 1997

Mitochondrial regulation of store-operated calcium signaling in T lymphocytes.
Hoth M, Fanger CM, Lewis RS.
J Cell Biol. 1997 May 5;137(3):633-648

Ca²⁺-induced Ca²⁺ release in Chinese hamster ovary (CHO) cells co-expressing dihydropyridine and ryanodine receptors.
Suda N, Franzius D, Fleig A, Nishimura S, Bödding M, Hoth M, Takeshima H, Penner R.
J Gen Physiol. 1997 May 1;109(5):619-631

Function follows form: The role of store-operated calcium channels in T cell activation.
Fanger CM, Zweifach A, Dolmetsch RE, Hoth M, Lewis RS.
Cell. Physiol. Biochem. (1997);7(3-4):203-218

Diversity of calcium entry mechanisms and their roles in cell signaling.
>Niemeyer B, Fanger CM, Hoth S, Hoth M.
Futura (1997);12(1):11-19

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Publications 1996

Depletion of intracellular calcium stores activates an outward potassium current in mast and RBL-1 cells that is correlated with CRAC channel activation.
Hoth M.
FEBS letters 390 (1996) 285-288

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Publications 1995

Characterization of T cells mutants with defects in capacitative calcium entry:genetic evidence for the physiological roles of CRAC channels.
Fanger CM, Hoth M, Crabtree GR, Lewis RS.
J Cell Biol. 1995 Nov;131(3):655-667

Calcium and barium permeation through calcium release-activated calcium (CRAC) channels.
Hoth M.
Pflugers Arch. Eur. J. Physiol. (1995 July). 430:315-322

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Publications 1994

Non-specific effects of calcium entry antagonists in mast cells.
Franzius D, Hoth M, Penner R.
Pflugers Arch. Eur. J. Physiol. (1994 June). 428:433-438

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Publications 1993

Ion channels and calcium signaling in mast cells.
Hoth M, Fasolato C, Penner R.
Ann. NY Acad. Sci. (1993 Dec 20);707:198-209

A GTP-dependent step in the activation mechanism of capacitative calcium influx.
Fasolato C, Hoth M, Penner R.
J. Biol. Chem. 1993 Oct 5;268(28):20737-40

Calcium influx and its control by calcium release.
Penner R, Fasolato C, Hoth M.
Cur. Opin. Neurobil. (1993 June);3(3):368-374

Calcium release-activated calcium current in rat mast cells.
Hoth M, Penner R.
J Physiol. (June 1, 1993), 465, 359-386

Multiple mechanisms of manganese-induced quenching of fura-2 fluorescence in rat mast cells.
Fasolato C, Hoth M, Penner R.
Pflugers Arch. Eur. J. Physiol. (1993 May). 423:225-231

Calcium and manganese influx through receptor-mediated activation of non-specific cation channels in mast cells.
Fasolato C, Hoth M, Matthews G, Penner R.
Proc. Natl. Acad. Sci. USA. 1993 Apr 1;90(7):3068-72

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Publications 1992

Depletion of intracellular calcium stores activates a calcium current in mast cells.
Hoth M, Penner R.
Nature 355,353-356 (23 January 1992).

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Publications 1991

Swapping of functional domains in voltage-gated K⁺ channels.
Stocker M, Pongs O, Hoth M, Heinemann SH, Stühmer W, Schröter K-H & Ruppersberg JP.
Proc. Biol. Sci. 1991 Aug 22;245(1313):101-7.