Immune Physiology

Research

Funding

Publications

					2025	2024	2023	2022	2021
2020	2019	2018	2017	2016	2015	2014	2013	2012	2011
2010	2009	2008	2007	2006	2005	2004	2003	2002	2001
2000	1999	1998	1997	1996	1995	1994	1993	1992	1991

Publications 2025

Hemmer, S., Hui, X., Draeger, J., Menges, J., Schwarz, E.C., Wrede, A., Oertel, J., Kaestner, L., Jung, G., Urbschat, S.
"AlkaPhos: a novel fluorescent probe as a potential point-of-care diagnostic tool to estimate recurrence risk of meningiomas"
Neurosurg Rev 48, 27-XX, (2025), DOI:10.1007/s10143-024-03172-8, Pubmed-ID: 39775316.

Publications 2024

Zöphel, S., Küchler, N., Jansky, J., Hoxha, C., Schäfer, G., Weise, J.J., Vialle, J., Kaschek, L., Stopper, G., Eichler, H., Yildiz, D., Moter, A., Wendel, P., Ullrich, E., Schormann, C., Rixecker, T., Cetin, O., Neumann, F., Orth, P., Bewarder, M., Hoth, M., Thurner, L., Schwarz, E.C.
"CD16+ as predictive marker for early relapse in aggressive B-NHL/DLBCL patients"
Mol Cancer 23, 210-XXX, (2024), DOI:10.1186/s12943-024-02123-7, Pubmed-ID: 39342291.

Burgstaller, A., Piernitzki, N., Küchler, N., Koch, M., Kister, T., Eichler, H., Kraus, T., Schwarz, E.C., Dustin, M.L., Lautenschläger, F., Staufer, O.
"Soft Synthetic Cells with Mobile Membrane Ligands for Ex Vivo Expansion of Therapy-Relevant T Cell Phenotypes"
Small 20, e2401844-XXXXXXXX, (2024), DOI:10.1002/smll.202401844, Pubmed-ID: 38751204.

Yanamandra, A. K. , Zhang, J., Montalvo, G., Zhou, X., Biedenweg, D., Zhao, R., Sharma, S., Hoth, M., Lautenschläger, F., Otto, O., Del Campo, A., Qu, B.
"PIEZO1-mediated mechanosensing governs NK-cell killing efficiency and infiltration in three-dimensional matrices"
Eur J Immunol 54, e2350693-XXXXXXXX, (2024), DOI:10.1002/eji.202350693, Pubmed-ID: 38279603.

Publications 2023

Dai, X., Zhou, X., Shao, R., Zhao, R., Yanamandra, A.K., Xing, Z., Ding, M., Wang, J., Liu, T., Zheng, Q., Zhang, P., Zhang, H., Wang, Y., Qu, B., Wang, Y.
"Bioactive Constituents of Verbena officinalis Alleviate Inflammation and Enhance Killing Efficiency of Natural Killer Cells"
Int J Mol Sci 24, 7144, (2023), DOI:10.3390/ijms24087144, Pubmed-ID: 37108306.

Yanamandra, A. K. , Bhusari, S., Del Campo, A., Sankaran, S., Qu, B.
"In vitro evaluation of immune responses to bacterial hydrogels for the development of living therapeutic materials"
Biomater Adv 153, 213554-XXXXXX, (2023), DOI:10.1016/j.bioadv.2023.213554, Pubmed-ID: 37480604.

Jóźwik, I. K. , Bombino, E., Abdulmughni, A., Hartz, P., Rozeboom, H.J., Wijma, H.J., Kappl, R., Janssen, D.B., Bernhardt, R., Thunnissen, A.W.H.
"Regio- and stereoselective steroid hydroxylation by CYP109A2 from Bacillus megaterium explored by X-ray crystallography and computational modeling"
FEBS J 290, 5016-5035, (2023), DOI:10.1111/febs.16906, Pubmed-ID: 37453052.

Zöphel, D., Kaschek, L., Steiner, R., Janku, S., Chang, H., Lis, A.
"Heterozygous OT-I mice reveal that antigen-specific CD8⁺ T cells shift from apoptotic to necrotic killers in the elderly"
Aging Cell 22, e13824-XXXXXX, (2023), DOI:10.1111/acel.13824, Pubmed-ID: 36947105.

Pagano, G., Botana, I.F., Wierz, M., Roessner, P.M., Ioannou, N., Zhou, X., Al-Hity, G., Borne, C., Gargiulo, E., Gonder, S., Qu, B., Stamatopoulos, B., Ramsay, A.G., Seiffert, M., Largeot, A., Moussay, E., Paggetti, J.
"Interleukin-27 potentiates CD8+ T-cell-mediated antitumor immunity in chronic lymphocytic leukemia"
Haematologica 108, 3011-3024, (2023), DOI:10.3324/haematol.2022.282474, Pubmed-ID: 37345470.

Kurth, M., Barayeu, U., Gharibi, H., Kuzhelev, A., Riedmiller, K., Zilke, J., Noack, K., Denysenkov, V., Kappl, R., Prisner, T.F., Zubarev, R.A., Dick, T.P., Gräter, F.
"DOPA Residues Endow Collagen with Radical Scavenging Capacity"
Angew Chem Int Ed Engl 62, e202216610-XXXXXXXXXX, (2023), DOI:10.1002/anie.202216610, Pubmed-ID: 37009775.

Lis, A., Zöphel, D.
"Elderly CD8⁺ T cells in the focus for immunotherapeutic approaches"
Aging (Albany NY) 15, 3899-3900, (2023), DOI:10.18632/aging.204747, Pubmed-ID: 37204431.

Thurner, L., Fadle, N., Regitz, E., Roth, S., Cetin, O., Kos, I.A., Hess, S.M., Bein, J., Bohle, R.M., Vornanen, M., Sundström, C., De Leval, L., Tiacci, E., Borchmann, P., Engert, A., Poeschel, V., Held, G., Schwarz, E.C., Neumann, F., Preuss, K., Hoth, M., Küppers, R., Lehman, K., Hansmann, M., Becker, S.L., Bewarder, M., Hartmann, S.
"B-cell receptor reactivity against Rothia mucilaginosa in nodular lymphocyte-predominant Hodgkin lymphoma"
Haematologica 108, 3347-3358, (2023), DOI:10.3324/haematol.2023.282698, Pubmed-ID: 37139600.

Zöphel, S., Schäfer, G., Nazarieh, M., Konetzki, V., Hoxha, C., Meese, E., Hoth, M., Helms, V., Hamed, M., Schwarz, E.C.
"Identification of molecular candidates which regulate calcium-dependent CD8⁺ T-cell cytotoxicity"
Mol Immunol 157, 202-213, (2023), DOI:10.1016/j.molimm.2023.04.002, Pubmed-ID: 37075611.

Kiefer, M., Thurner, L., Bock, T., Cetin, O., Kos, I., Lesan, V., Kaddu-Mulindwa, D., Bittenbring, J.T., Fadle, N., Regitz, E., Hoth, M., Neumann, F., Preuss, K., Pfreundschuh, M., Christofyllakis, K., Bewarder, M.
"Ars2-containing bispecific, Fab- and IgG1-format BAR-bodies to target DLBCL cells"
EJHaem 4, 125-134, (2023), DOI:10.1002/jha2.635, Pubmed-ID: 36819155.

Barayeu, U., Schilling, D., Eid, M., Xavier da Silva, T.N., Schlicker, L., Mitreska, N., Zapp, C., Gräter, F., Miller, A.K., Kappl, R., Schulze, A., Friedmann Angeli, J.P., Dick, T.P.
"Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals"
Nat Chem Biol 19, 28-37, (2023), DOI:10.1038/s41589-022-01145-w, Pubmed-ID: 36109647.

Slowik, E. J. , Stankoska, K., Bui, N.N., Pasieka, B., Conrad, D., Zapp, J., Hoth, M., Bogeski, I., Kappl, R.
"The calcium channel modulator 2-APB hydrolyzes in physiological buffers and acts as an effective radical scavenger and inhibitor of the NADPH oxidase 2"
Redox Biol 61, 102654-XXXXXX, (2023), DOI:10.1016/j.redox.2023.102654, Pubmed-ID: 36889081.

Publications 2022

Friedmann, K. S. , Kaschek, L., Knörck, A., Cappello, S., Lünsmann, N., Küchler, N., Hoxha, C., Schäfer, G., Iden, S., Bogeski, I., Kummerow, C., Schwarz, E.C., Hoth, M.
"Interdependence of sequential cytotoxic T lymphocyte and natural killer cell cytotoxicity against melanoma cells"
J Physiol 600, 5027-5054, (2022), DOI:10.1113/JP283667, Pubmed-ID: 36226443.

Stejerean-Todoran, I., Zimmermann, K., Gibhardt, C.S., Vultur, A., Ickes, C., Shannan, B., Bonilla Del Rio, Z., Wölling, A., Cappello, S., Sung, H., Shumanska, M., Zhang, X., Nanadikar, M., Latif, M.U., Wittek, A., Lange, F., Waters, A., Brafford, P., Wilting, J., Urlaub, H., Katschinski, D.M., Rehling, P., Lenz, C., Jakobs, S., Ellenrieder, V., Roesch, A., Schön, M.P., Herlyn, M., Stanisz, H., Bogeski, I.
"MCU controls melanoma progression through a redox-controlled phenotype switch"
EMBO Rep 23, e54746-XXXXXX, (2022), DOI:10.15252/embr.202254746, Pubmed-ID: 36156348.

Sahoo, N., Yang, K., Coburger, I., Bernert, A., Swain, S.M., Gessner, G., Kappl, R., Kühl, T., Imhof, D., Hoshi, T., Schönherr, R., Heinemann, S.H.
"Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1"
Sci Rep 12, 14645-XXXXX, (2022), DOI:10.1038/s41598-022-18975-2, Pubmed-ID: 36030326.

Zöphel, D., Angenendt, A., Kaschek, L., Ravichandran, K., Hof, C., Janku, S., Hoth, M., Lis, A.
"Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxic CD8⁺ T cells boost cancer cell elimination"
Aging Cell 21, e13668-XXXXXX, (2022), DOI:10.1111/acel.13668, Pubmed-ID: 35818124.

Wrublewsky, S., Glas, J., Carlein, C., Nalbach, L., Hoffmann, M.l.A., Pack, M., Vilas-Boas, E.A., Ribot, N., Kappl, R., Menger, M.D., Laschke, M.W., Ampofo, E., Roma, L.P.
"The loss of pancreatic islet NADPH oxidase (NOX)2 improves islet transplantation"
Redox Biol 55, 102419-XXXXXX, (2022), DOI:10.1016/j.redox.2022.102419, Pubmed-ID: 35933903.

Bock, T., Bewarder, M., Cetin, O., Fadle, N., Regitz, E., Schwarz, E.C., Held, J., Roth, S., Lohse, S., Pfuhl, T., Wagener, R., Smola, S., Becker, S.L., Bohle, R.M., Trümper, L., Siebert, R., Hansmann, M., Pfreundschuh, M., Drexler, H.G., Hoth, M., Kubuschok, B., Roemer, K., Preuss, K., Hartmann, S., Thurner, L.
"B-cell receptors of EBV-negative Burkitt lymphoma bind modified isoforms of autoantigens"
EJHaem 3, 739-747, (2022), DOI:10.1002/jha2.475, Pubmed-ID: 36051037.

Knörck, A., Schäfer, G., Alansary, D., Richter, J., Thurner, L., Hoth, M., Schwarz, E.C.
"Cytotoxic Efficiency of Human CD8⁺ T Cell Memory Subtypes"
Front Immunol 13, 838484-XXXXXX, (2022), DOI:10.3389/fimmu.2022.838484, Pubmed-ID: 35493468.

Souza Bomfim, G. H. , Niemeyer, B.A., Lacruz, R.S., Lis, A.
"On the Connections between TRPM Channels and SOCE"
Cells 11, 1190, (2022), DOI:10.3390/cells11071190, Pubmed-ID: 35406753.

Yang, W., Denger, A., Diener, C., Küppers, F., Soriano-Baguet, L., Schäfer, G., Yanamandra, A.K., Zhao, R., Knörck, A., Schwarz, E.C., Hart, M., Lammert, F., Roma, L.P., Brenner, D., Christidis, G., Helms, V., Meese, E., Hoth, M., Qu, B.
"Unspecific CTL Killing Is Enhanced by High Glucose via TNF-Related Apoptosis-Inducing Ligand"
Front Immunol 13, 831680-XXXXXX, (2022), DOI:10.3389/fimmu.2022.831680, Pubmed-ID: 35265081.

Kaddu-Mulindwa, D., Altmann, B., Robrecht, S., Ziepert, M., Regitz, E., Tausch, E., Held, G., Poeschel, V., Lesan, V., Bittenbring, J.T., Thurner, L., Pfreundschuh, M., Christofyllakis, K., Truemper, L., Loeffler, M., Schmitz, N., Hoth, M., Hallek, M., Fischer, K., Stilgenbauer, S., Bewarder, M., Rixecker, T.M.
"KIR2DS1-HLA-C status as a predictive marker for benefit from rituximab: a post-hoc analysis of the RICOVER-60 and CLL8 trials"
Lancet Haematol 9, e133-e142, (2022), DOI:10.1016/S2352-3026(21)00369-0, Pubmed-ID: 35114151.

Knapp, M. L. , Alansary, D., Poth, V., Förderer, K., Sommer, F., Zimmer, D., Schwarz, Y., Künzel, N., Kless, A., Machaca, K., Helms, V., Mühlhaus, T., Schroda, M., Lis, A., Niemeyer, B.A.
"A longer isoform of Stim1 is a negative SOCE regulator but increases cAMP-modulated NFAT signaling"
EMBO Rep 23, e53135-XXXXXX, (2022), DOI:10.15252/embr.202153135, Pubmed-ID: 34942054.

Cui, F., Shen, X., Cao, B., Ji, H., Liu, J., Zhuang, X., Zeng, C., Qu, B., Li, S., Xu, Y., Zhou, Q.
"Bacterial identification and adhesive strength evaluation based on a mannose biosensor with dual-mode detection"
Biosens Bioelectron 203, 114044-XXXXXX, (2022), DOI:10.1016/j.bios.2022.114044, Pubmed-ID: 35123316.

Zhou, X., Zhao, R., Yanamandra, A.K., Hoth, M., Qu, B.
"Light-Sheet Scattering Microscopy to Visualize Long-Term Interactions Between Cells and Extracellular Matrix"
Front Immunol 13, 828634-XXXXXX, (2022), DOI:10.3389/fimmu.2022.828634, Pubmed-ID: 35154150.

Särchen, V., Shanmugalingam, S., Kehr, S., Reindl, L.M., Greze, V., Wiedemann, S., Boedicker, C., Jacob, M., Bankov, K., Becker, N., Wehner, S., Theilen, T.M., Gretser, S., Gradhand, E., Kummerow, C., Ullrich, E., Vogler, M.
"Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy"
Cell Death Discov 8, 11-XX, (2022), DOI:10.1038/s41420-021-00812-6, Pubmed-ID: 35013156.

Publications 2021

Darras, A., Breunig, H.G., John, T., Zhao, R., Koch, J., Kummerow, C., König, K., Wagner, C., Kaestner, L.
"Imaging Erythrocyte Sedimentation in Whole Blood"
Front Physiol 12, 729191-XXXXXX, (2021), DOI:10.3389/fphys.2021.729191, Pubmed-ID: 35153805.

Bertero, E., Nickel, A., Kohlhaas, M., Hohl, M., Sequeira, V., Brune, C., Schwemmlein, J., Abeßer, M., Schuh, K., Kutschka, I., Carlein, C., Münker, K., Atighetchi, S., Müller, A., Kazakov, A., Kappl, R., von der Malsburg, K., van der Laan, M., Schiuma, A., Böhm, M., Laufs, U., Hoth, M., Rehling, P., Kuhn, M., Dudek, J., von der Malsburg, A., Prates Roma, L., Maack, C.
"Loss of Mitochondrial Ca²⁺ Uniporter Limits Inotropic Reserve and Provides Trigger and Substrate for Arrhythmias in Barth Syndrome Cardiomyopathy"
Circulation 144, 1694-1713, (2021), DOI:10.1161/CIRCULATIONAHA.121.053755, Pubmed-ID: 34648376.

Cappello, S., Sung, H., Ickes, C., Gibhardt, C.S., Vultur, A., Bhat, H., Hu, Z., Brafford, P., Denger, A., Stejerean-Todoran, I., Köhn, R., Lorenz, V., Künzel, N., Salinas, G., Stanisz, H., Legler, T., Rehling, P., Schön, M.P., Lang, K.S., Helms, V., Herlyn, M., Hoth, M., Kummerow, C., Bogeski, I.
"Protein Signatures of NK Cell-Mediated Melanoma Killing Predict Response to Immunotherapies"
Cancer Res 81, 5540-5554, (2021), DOI:10.1158/0008-5472.CAN-21-0164, Pubmed-ID: 34518212.

Zhao, R., Zhou, X., Khan, E.S., Alansary, D., Friedmann, K.S., Yang, W., Schwarz, E.C., Del Campo, A., Hoth, M., Qu, B.
"Targeting the Microtubule-Network Rescues CTL Killing Efficiency in Dense 3D Matrices"
Front Immunol 12, 729820-XXXXXX, (2021), DOI:10.3389/fimmu.2021.729820, Pubmed-ID: 34484240.

Jung, P., Zhou, X., Iden, S., Bischoff, M., Qu, B.
"T cell stiffness is enhanced upon formation of immunological synapse"
Elife 10, e66643, (2021), DOI:10.7554/eLife.66643, Pubmed-ID: 34313220.

Kaschek, L., Zöphel, S., Knörck, A., Hoth, M.
"A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity"
Semin Cell Dev Biol 115, 10-18, (2021), DOI:10.1016/j.semcdb.2020.12.002, Pubmed-ID: 33358089.

Bewarder, M., Kiefer, M., Will, H., Olesch, K., Moelle, C., Stilgenbauer, S., Christofyllakis, K., Kaddu-Mulindwa, D., Bittenbring, J.T., Fadle, N., Regitz, E., Kaschek, L., Hoth, M., Neumann, F., Preuss, K., Pfreundschuh, M., Thurner, L.
"The B-cell Receptor Autoantigen LRPAP1 Can Replace Variable Antibody Regions to Target Mantle Cell Lymphoma Cells"
Hemasphere 5, e620-XXXX, (2021), DOI:10.1097/HS9.0000000000000620, Pubmed-ID: 34263144.

Liu, Y., Zhao, R., Reda, B., Yang, W., Hannig, M., Qu, B.
"Profiling of cytokines, chemokines and growth factors in saliva and gingival crevicular fluid"
Cytokine 142, 155504-XXXXXX, (2021), DOI:10.1016/j.cyto.2021.155504, Pubmed-ID: 33775492.

Zhu, J., Yang, W., Zhou, X., Zöphel, D., Soriano-Baguet, L., Dolgener, D., Carlein, C., Hof, C., Zhao, R., Ye, S., Schwarz, E.C., Brenner, D., Prates Roma, L., Qu, B.
"High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity"
Front Immunol 12, 689337-XXXXXX, (2021), DOI:10.3389/fimmu.2021.689337, Pubmed-ID: 34248978.

Zheng, Y., Han, M.K.L., Zhao, R., Blass, J., Zhang, J., Zhou, D.W., Colard-Itté, J., Dattler, D., Çolak, A., Hoth, M., García, A.J., Qu, B., Bennewitz, R., Giuseppone, N., Del Campo, A.
"Optoregulated force application to cellular receptors using molecular motors"
Nat Commun 12, 3580-XXXX, (2021), DOI:10.1038/s41467-021-23815-4, Pubmed-ID: 34117256.

Ritzmann, F., Borchardt, K., Vella, G., Chitirala, P., Angenendt, A., Herr, C., Menger, M.D., Hoth, M., Lis, A., Bohle, R.M., Bals, R., Beisswenger, C.
"Blockade of PD-1 decreases neutrophilic inflammation and lung damage in experimental COPD"
Am J Physiol Lung Cell Mol Physiol 320, L958-L968, (2021), DOI:10.1152/ajplung.00121.2020, Pubmed-ID: 33759577.

Vesperini, D., Montalvo, G., Qu, B., Lautenschläger, F.
"Characterization of immune cell migration using microfabrication"
Biophys Rev 13, 185-202, (2021), DOI:10.1007/s12551-021-00787-9, Pubmed-ID: 34290841.

Zhang, J., Zhao, R., Li, B., Farrukh, A., Hoth, M., Qu, B., Del Campo, A.
"Micropatterned soft hydrogels to study the interplay of receptors and forces in T cell activation"
Acta Biomater 119, 234-246, (2021), DOI:10.1016/j.actbio.2020.10.028, Pubmed-ID: 33099024.

Publications 2020

Zou, H., Yang, W., Schwär, G., Zhao, R., Alansary, D., Yin, D., Schwarz, E.C., Niemeyer, B.A., Qu, B.
"High glucose distinctively regulates Ca²⁺ influx in cytotoxic T lymphocytes upon target recognition and thapsigargin stimulation"
Eur J Immunol 50, 2095-2098, (2020), DOI:10.1002/eji.202048577, Pubmed-ID: 32697355.

Zöphel, D., Hof, C., Lis, A.
"Altered Ca²⁺ Homeostasis in Immune Cells during Aging: Role of Ion Channels"
Int J Mol Sci 22, 110, (2020), DOI:10.3390/ijms22010110, Pubmed-ID: 33374304.

Thurner, L., Hartmann, S., Neumann, F., Hoth, M., Stilgenbauer, S., Küppers, R., Preuss, K., Bewarder, M.
"Role of Specific B-Cell Receptor Antigens in Lymphomagenesis"
Front Oncol 10, 604685-XXXXXX, (2020), DOI:10.3389/fonc.2020.604685, Pubmed-ID: 33363034.

Zhou, Y., Zhao, R., Schwarz, E.C., Akbar, R., Kaba, M., Pattu, V., Helms, V., Rieger, H., Nunes-Hasler, P., Qu, B.
"Interorganelle Tethering to Endocytic Organelles Determines Directional Cytokine Transport in CD4⁺ T Cells"
J Immunol 205, 2988-3000, (2020), DOI:10.4049/jimmunol.2000195, Pubmed-ID: 33106338.

Sadjadi, Z., Zhao, R., Hoth, M., Qu, B., Rieger, H.
"Migration of Cytotoxic T Lymphocytes in 3D Collagen Matrices"
Biophys J 119, 2141-2152, (2020), DOI:10.1016/j.bpj.2020.10.020, Pubmed-ID: 33264597.

Höfer, D., Körbel, C., Laschke, M.W., Veith, N.T., Pohlemann, T., Kappl, R., Tschernig, T.
"Experimental induction of blunt chest trauma in mice: A modified approach with evaluation in dummies and cadavers"
Exp Ther Med 20, 28-XX, (2020), DOI:10.3892/etm.2020.9156, Pubmed-ID: 32952619.

Bewarder, M., Kiefer, M., Moelle, C., Goerens, L., Stilgenbauer, S., Christofyllakis, K., Kaddu-Mulindwa, D., Fadle, N., Regitz, E., Neumann, F., Hoth, M., Preuss, K., Pfreundschuh, M., Thurner, L.
"Integration of the B-Cell Receptor Antigen Neurabin-I/SAMD14 Into an Antibody Format as New Therapeutic Approach for the Treatment of Primary CNS Lymphoma"
Front Oncol 10, 580364-XXXXXX, (2020), DOI:10.3389/fonc.2020.580364, Pubmed-ID: 33282736.

Gibhardt, C. S. , Cappello, S., Bhardwaj, R., Schober, R., Kirsch, S.A., Bonilla Del Rio, Z., Gahbauer, S., Bochicchio, A., Sumanska, M., Ickes, C., Stejerean-Todoran, I., Mitkovski, M., Alansary, D., Zhang, X., Revazian, A., Fahrner, M., Lunz, V., Frischauf, I., Luo, T., Ezerina, D., Messens, J., Belousov, V.V., Hoth, M., Böckmann, R.A., Hediger, M.A., Schindl, R., Bogeski, I.
"Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry"
Cell Rep 33, 108292-XXXXXX, (2020), DOI:10.1016/j.celrep.2020.108292, Pubmed-ID: 33086068.

Zapp, C., Obarska-Kosinska, A., Rennekamp, B., Kurth, M., Hudson, D.M., Mercadante, D., Barayeu, U., Dick, T.P., Denysenkov, V., Prisner, T., Bennati, M., Daday, C., Kappl, R., Gräter, F.
"Mechanoradicals in tensed tendon collagen as a source of oxidative stress"
Nat Commun 11, 2315-XXXX, (2020), DOI:10.1038/s41467-020-15567-4, Pubmed-ID: 32385229.

Nickel, A. G. , Kohlhaas, M., Bertero, E., Wilhelm, D., Wagner, M., Sequeira, V., Kreusser, M.M., Dewenter, M., Kappl, R., Hoth, M., Dudek, J., Backs, J., Maack, C.
"CaMKII does not control mitochondrial Ca²⁺ uptake in cardiac myocytes"
J Physiol 598, 1361-1376, (2020), DOI:10.1113/JP276766, Pubmed-ID: 30770570.

Shu, Y., Wang, Y., Lv, W., Peng, D., Li, J., Zhang, H., Jiang, G., Yang, B., Liu, S., Zhang, J., Chen, Y., Tang, S., Wan, K., Yuan, J., Guo, W., Fu, G., Qi, X., Liu, Z., Liu, H., Yang, C., Zhang, L., Liu, F., Yu, J., Zhang, P., Qu, B., Zhao, H., He, T., Zou, L.
"ARRB1-Promoted NOTCH1 Degradation Is Suppressed by OncomiR miR-223 in T-cell Acute Lymphoblastic Leukemia"
Cancer Res 80, 988-998, (2020), DOI:10.1158/0008-5472.CAN-19-1471, Pubmed-ID: 31822496.

Angenendt, A., Steiner, R., Knörck, A., Schwär, G., Konrad, M., Krause, E., Lis, A.
"Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8⁺ T cells of elderly mice"
Aging (Albany NY) 12, 3266-3286, (2020), DOI:10.18632/aging.102809, Pubmed-ID: 32062611.

Stankevicins, L., Ecker, N., Terriac, E., Maiuri, P., Schoppmeyer, R., Vargas, P., Lennon-Duménil, A., Piel, M., Qu, B., Hoth, M., Kruse, K., Lautenschläger, F.
"Deterministic actin waves as generators of cell polarization cues"
Proc Natl Acad Sci U S A 117, 826-835, (2020), DOI:10.1073/pnas.1907845117, Pubmed-ID: 31882452.

Publications 2019

Zwick, A., Bernhard, M., Knoerck, A., Linxweiler, M., Schick, B., Heinzelmann, J., Smola, S., Lohse, S.
"Monitoring kinetics reveals critical parameters of IgA-dependent granulocyte-mediated anti-tumor cell cytotoxicity"
J Immunol Methods 473, 112644-XXXXXX, (2019), DOI:10.1016/j.jim.2019.112644, Pubmed-ID: 31404549.

Zhang, X., Gibhardt, C.S., Will, T., Stanisz, H., Körbel, C., Mitkovski, M., Stejerean, I., Cappello, S., Pacheu-Grau, D., Dudek, J., Tahbaz, N., Mina, L., Simmen, T., Laschke, M.W., Menger, M.D., Schön, M.P., Helms, V., Niemeyer, B.A., Rehling, P., Vultur, A., Bogeski, I.
"Redox signals at the ER-mitochondria interface control melanoma progression"
EMBO J 38, e100871-XXXXXXX, (2019), DOI:10.15252/embj.2018100871, Pubmed-ID: 31304984.

Ritzmann, F., Jungnickel, C., Vella, G., Kamyschnikow, A., Herr, C., Li, D., Menger, M.M., Angenendt, A., Hoth, M., Lis, A., Bals, R., Beisswenger, C.
"IL-17C-mediated innate inflammation decreases the response to PD-1 blockade in a model of Kras-driven lung cancer"
Sci Rep 9, 10353-XXXXX, (2019), DOI:10.1038/s41598-019-46759-8, Pubmed-ID: 31316109.

Schmidt, B., Alansary, D., Bogeski, I., Niemeyer, B.A., Rieger, H.
"Reaction-diffusion model for STIM-ORAI interaction: The role of ROS and mutations"
J Theor Biol 470, 64-75, (2019), DOI:10.1016/j.jtbi.2019.02.010, Pubmed-ID: 30853394.

Angenendt, L., Bormann, E., Pabst, C., Alla, V., Görlich, D., Braun, L., Dohlich, K., Schwöppe, C., Bohlander, S.K., Arteaga, M.F., Wethmar, K., Hartmann, W., Angenendt, A., Kessler, T., Mesters, R.M., Stelljes, M., Rothenberg-Thurley, M., Spiekermann, K., Hébert, J., Sauvageau, G., Valk, P.J.M., Löwenberg, B., Serve, H., Müller-Tidow, C., Lenz, G., Wörmann, B.J., Sauerland, M.C., Hiddemann, W., Berdel, W.E., Krug, U., Metzeler, K.H., Mikesch, J., Herold, T., Schliemann, C.
"The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia"
Leukemia 33, 2830-2841, (2019), DOI:10.1038/s41375-019-0505-x, Pubmed-ID: 31182782.

Gulaboski, R., Mirčeski, V., Kappl, R., Hoth, M., Bozem, M.
"Review—Quantification of Hydrogen Peroxide by Electrochemical Methods and Electron Spin Resonance Spectroscopy"
166, G82, (2019), DOI:10.1149/2.1061908jes.

Frisch, J., Angenendt, A., Hoth, M., Prates Roma, L., Lis, A.
"STIM-Orai Channels and Reactive Oxygen Species in the Tumor Microenvironment"
Cancers (Basel) 11, 457, (2019), DOI:10.3390/cancers11040457, Pubmed-ID: 30935064.

Wang, C., Gu, Y., Zhang, E., Zhang, K., Qin, N., Dai, J., Zhu, M., Liu, J., Xie, K., Jiang, Y., Guo, X., Liu, M., Jin, G., Ma, H., Jiang, T., Yin, R., Xia, Y., Liu, L., Wang, S., Shen, B., Huo, R., Xu, L., Sha, J., Qu, B., Shen, H., Hu, Z.
"A cancer-testis non-coding RNA LIN28B-AS1 activates driver gene LIN28B by interacting with IGF2BP1 in lung adenocarcinoma"
Oncogene 38, 1611-1624, (2019), DOI:10.1038/s41388-018-0548-x, Pubmed-ID: 30353165.

Knowles, L. M. , Kagiri, D., Bernard, M., Schwarz, E.C., Eichler, H., Pilch, J.
"Macrophage Polarization is Deregulated in Haemophilia"
Thromb Haemost 119, 234-245, (2019), DOI:10.1055/s-0038-1676796, Pubmed-ID: 30650445.

Leisegang, M. S. , Gu, L., Preussner, J., Günther, S., Hitzel, J., Ratiu, C., Weigert, A., Chen, W., Schwarz, E.C., Looso, M., Fork, C., Brandes, R.P.
"The histone demethylase PHF8 facilitates alternative splicing of the histocompatibility antigen HLA-G"
FEBS Lett 593, 487-498, (2019), DOI:10.1002/1873-3468.13337, Pubmed-ID: 30758047.

Hart, M., Walch-Rückheim, B., Friedmann, K.S., Rheinheimer, S., Tänzer, T., Glombitza, B., Sester, M., Lenhof, H., Hoth, M., Schwarz, E.C., Keller, A., Meese, E.
"miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling"
Cell Death Dis 10, 46-XX, (2019), DOI:10.1038/s41419-018-1295-1, Pubmed-ID: 30718475.

Friedmann, K. S. , Bozem, M., Hoth, M.
"Calcium signal dynamics in T lymphocytes: Comparing in vivo and in vitro measurements"
Semin Cell Dev Biol 94, 84-93, (2019), DOI:10.1016/j.semcdb.2019.01.004, Pubmed-ID: 30630031.

Publications 2018

Suzuki, S., Lis, A., Schmitz, C., Penner, R., Fleig, A.
"The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins"
Cell Mol Life Sci 75, 3069-3078, (2018), DOI:10.1007/s00018-018-2786-z, Pubmed-ID: 29500477.

Przibilla, J., Dembla, S., Rizun, O., Lis, A., Jung, M., Oberwinkler, J., Beck, A., Philipp, S.E.
"Ca²⁺-dependent regulation and binding of calmodulin to multiple sites of Transient Receptor Potential Melastatin 3 (TRPM3) ion channels"
Cell Calcium 73, 40-52, (2018), DOI:10.1016/j.ceca.2018.03.005, Pubmed-ID: 29880196.

Backes, C. S. , Friedmann, K.S., Mang, S., Knörck, A., Hoth, M., Kummerow, C.
"Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification, and modulation of apoptosis, necrosis, and mixed forms"
J Biol Chem 293, 16348-16363, (2018), DOI:10.1074/jbc.RA118.004549, Pubmed-ID: 30190323.

Klein, M., Zimmermann, K., Schorr, S., Landini, M., Klemens, P.A.W., Altensell, J., Jung, M., Krause, E., Nguyen, D., Helms, V., Rettig, J., Fecher-Trost, C., Cavalié, A., Hoth, M., Bogeski, I., Neuhaus, H.E., Zimmermann, R., Lang, S., Haferkamp, I.
"AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticulum"
Nat Commun 9, 3489-XXXX, (2018), DOI:10.1038/s41467-018-06003-9, Pubmed-ID: 30154480.

Bozem, M., Knapp, P., Mirčeski, V., Slowik, E.J., Bogeski, I., Kappl, R., Heinemann, C., Hoth, M.
"Electrochemical Quantification of Extracellular Local H₂O₂ Kinetics Originating from Single Cells"
Antioxid Redox Signal 29, 501-517, (2018), DOI:10.1089/ars.2016.6840, Pubmed-ID: 28314376.

Schoppmeyer, R., Zhao, R., Hoth, M., Qu, B.
"Light-sheet Microscopy for Three-dimensional Visualization of Human Immune Cells"
J Vis Exp, 57651, (2018), DOI:10.3791/57651, Pubmed-ID: 29985362.

Knörck, A., Marx, S., Friedmann, K.S., Zöphel, S., Lieblang, L., Hässig, C., Müller, I., Pilch, J., Sester, U., Hoth, M., Eichler, H., Sester, M., Schwarz, E.C.
"Quantity, quality, and functionality of peripheral blood cells derived from residual blood of different apheresis kits"
Transfusion 58, 1516-1526, (2018), DOI:10.1111/trf.14616, Pubmed-ID: 29732580.

Zhou, X., Friedmann, K.S., Lyrmann, H., Zhou, Y., Schoppmeyer, R., Knörck, A., Mang, S., Hoxha, C., Angenendt, A., Backes, C.S., Mangerich, C., Zhao, R., Cappello, S., Schwär, G., Hässig, C., Neef, M., Bufe, B., Zufall, F., Kruse, K., Niemeyer, B.A., Lis, A., Qu, B., Kummerow, C., Schwarz, E.C., Hoth, M.
"A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity"
J Physiol 596, 2681-2698, (2018), DOI:10.1113/JP274964, Pubmed-ID: 29368348.

Publications 2017

Klein-Hessling, S., Muhammad, K., Klein, M., Pusch, T., Rudolf, R., Flöter, J., Qureischi, M., Beilhack, A., Vaeth, M., Kummerow, C., Backes, C., Schoppmeyer, R., Hahn, U., Hoth, M., Bopp, T., Berberich-Siebelt, F., Patra, A., Avots, A., Müller, N., Schulze, A., Serfling, E.
"NFATc1 controls the cytotoxicity of CD8⁺ T cells"
Nat Commun 8, 511-XXX, (2017), DOI:10.1038/s41467-017-00612-6, Pubmed-ID: 28894104.

Schoppmeyer, R., Zhao, R., Cheng, H., Hamed, M., Liu, C., Zhou, X., Schwarz, E.C., Zhou, Y., Knörck, A., Schwär, G., Ji, S., Liu, L., Long, J., Helms, V., Hoth, M., Yu, X., Qu, B.
"Human profilin 1 is a negative regulator of CTL mediated cell-killing and migration"
Eur J Immunol 47, 1562-1572, (2017), DOI:10.1002/eji.201747124, Pubmed-ID: 28688208.

Zhou, X., Zhao, R., Schwarz, K., Mangeat, M., Schwarz, E.C., Hamed, M., Bogeski, I., Helms, V., Rieger, H., Qu, B.
"Bystander cells enhance NK cytotoxic efficiency by reducing search time"
Sci Rep 7, 44357-XXXXX, (2017), DOI:10.1038/srep44357, Pubmed-ID: 28287155.

Stapel, B., Kohlhaas, M., Ricke-Hoch, M., Haghikia, A., Erschow, S., Knuuti, J., Silvola, J.M.U., Roivainen, A., Saraste, A., Nickel, A.G., Saar, J.A., Sieve, I., Pietzsch, S., Müller, M., Bogeski, I., Kappl, R., Jauhiainen, M., Thackeray, J.T., Scherr, M., Bengel, F.M., Hagl, C., Tudorache, I., Bauersachs, J., Maack, C., Hilfiker-Kleiner, D.
"Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy"
Eur Heart J 38, 349-361, (2017), DOI:10.1093/eurheartj/ehw086, Pubmed-ID: 28201733.

Eisenbeis, J., Peisker, H., Backes, C.S., Bur, S., Hölters, S., Thewes, N., Greiner, M., Junker, C., Schwarz, E.C., Hoth, M., Junker, K., Preissner, K.T., Jacobs, K., Herrmann, M., Bischoff, M.
"The extracellular adherence protein (Eap) of Staphylococcus aureus acts as a proliferation and migration repressing factor that alters the cell morphology of keratinocytes"
Int J Med Microbiol 307, 116-125, (2017), DOI:10.1016/j.ijmm.2017.01.002, Pubmed-ID: 28117265.

Weingärtner, O., Bogeski, I., Kummerow, C., Schirmer, S.H., Husche, C., Vanmierlo, T., Wagenpfeil, G., Hoth, M., Böhm, M., Lütjohann, D., Laufs, U.
"Plant sterol ester diet supplementation increases serum plant sterols and markers of cholesterol synthesis, but has no effect on total cholesterol levels"
J Steroid Biochem Mol Biol 169, 219-225, (2017), DOI:10.1016/j.jsbmb.2016.07.016, Pubmed-ID: 27473562.

Publications 2016

Maccari, I., Zhao, R., Peglow, M., Schwarz, K., Hornak, I., Pasche, M., Quintana, A., Hoth, M., Qu, B., Rieger, H.
"Cytoskeleton rotation relocates mitochondria to the immunological synapse and increases calcium signals"
Cell Calcium 60, 309-321, (2016), DOI:10.1016/j.ceca.2016.06.007, Pubmed-ID: 27451384.

Gulaboski, R., Bogeski, I., Kokoskarova, P., Haeri, H.H., Mitrev, S., Stefova, M., Stanoeva, J.P., Markovski, V., Mirčeski, V., Hoth, M., Kappl, R.
"New insights into the chemistry of Coenzyme Q-0: A voltammetric and spectroscopic study"
Bioelectrochemistry 111, 100-108, (2016), DOI:10.1016/j.bioelechem.2016.05.008, Pubmed-ID: 27268099.

Tang, Q., Holland-Letz, T., Slynko, A., Cuk, K., Marme, F., Schott, S., Heil, J., Qu, B., Golatta, M., Bewerunge-Hudler, M., Sutter, C., Surowy, H., Wappenschmidt, B., Schmutzler, R., Hoth, M., Bugert, P., Bartram, C.R., Sohn, C., Schneeweiss, A., Yang, R., Burwinkel, B.
"DNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA"
Oncotarget 7, 64191-64202, (2016), DOI:10.18632/oncotarget.11640, Pubmed-ID: 27577081.

Alansary, D., Schmidt, B., Dörr, K., Bogeski, I., Rieger, H., Kless, A., Niemeyer, B.A.
"Thiol dependent intramolecular locking of Orai1 channels"
Sci Rep 6, 33347-XXXXX, (2016), DOI:10.1038/srep33347, Pubmed-ID: 27624281.

Gibhardt, C. S. , Zimmermann, K.M., Zhang, X., Belousov, V.V., Bogeski, I.
"Imaging calcium and redox signals using genetically encoded fluorescent indicators"
Cell Calcium 60, 55-64, (2016), DOI:10.1016/j.ceca.2016.04.008, Pubmed-ID: 27142890.

Schwarz, K., Schröder, Y., Qu, B., Hoth, M., Rieger, H.
"Optimality of Spatially Inhomogeneous Search Strategies"
Phys Rev Lett 117, 068101-XXXXXX, (2016), DOI:10.1103/PhysRevLett.117.068101, Pubmed-ID: 27541477.

Bhat, S. S. , Friedmann, K.S., Knörck, A., Hoxha, C., Leidinger, P., Backes, C., Meese, E., Keller, A., Rettig, J., Hoth, M., Qu, B., Schwarz, E.C.
"Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes"
Biochim Biophys Acta 1863, 1653-1664, (2016), DOI:10.1016/j.bbamcr.2016.04.014, Pubmed-ID: 27094127.

Stanisz, H., Vultur, A., Herlyn, M., Roesch, A., Bogeski, I.
"The role of Orai-STIM calcium channels in melanocytes and melanoma"
J Physiol 594, 2825-2835, (2016), DOI:10.1113/JP271141, Pubmed-ID: 26864956.

Tosatto, A., Sommaggio, R., Kummerow, C., Bentham, R.B., Blacker, T.S., Berecz, T., Duchen, M.R., Rosato, A., Bogeski, I., Szabadkai, G., Rizzuto, R., Mammucari, C.
"The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α"
EMBO Mol Med 8, 569-585, (2016), DOI:10.15252/emmm.201606255, Pubmed-ID: 27138568.

Haeri, H. H. , Bogeski, I., Gulaboski, R., Mirceski, V., Hoth, M., Kappl, R.
"An EPR and DFT study on the primary radical formed in hydroxylation reactions of 2,6-dimethoxy-1,4-benzoquinone"
Molecular Physics 114, 1856-1866, (2016), DOI:10.1080/00268976.2016.1158424.

Saul, S., Gibhardt, C.S., Schmidt, B., Lis, A., Pasieka, B., Conrad, D., Jung, P., Gaupp, R., Wonnenberg, B., Diler, E., Stanisz, H., Vogt, T., Schwarz, E.C., Bischoff, M., Herrmann, M., Tschernig, T., Kappl, R., Rieger, H., Niemeyer, B.A., Bogeski, I.
"A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels"
Sci Signal 9, ra26-XXXX, (2016), DOI:10.1126/scisignal.aaf1639, Pubmed-ID: 26956485.

Dörr, K., Kilch, T., Kappel, S., Alansary, D., Schwär, G., Niemeyer, B.A., Peinelt, C.
"Cell type-specific glycosylation of Orai1 modulates store-operated Ca2+ entry"
Sci Signal 9, ra25-XXXX, (2016), DOI:10.1126/scisignal.aaa9913, Pubmed-ID: 26956484.

Appenzeller-Herzog, C., Bánhegyi, G., Bogeski, I., Davies, K.J.A., Delaunay-Moisan, A., Forman, H.J., Görlach, A., Kietzmann, T., Laurindo, F., Margittai, E., Meyer, A.J., Riemer, J., Rützler, M., Simmen, T., Sitia, R., Toledano, M.B., Touw, I.P.
"Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish"
Free Radic Biol Med 94, 157-160, (2016), DOI:10.1016/j.freeradbiomed.2016.02.030, Pubmed-ID: 26928585.

Schwarz, E. C. , Backes, C., Knörck, A., Ludwig, N., Leidinger, P., Hoxha, C., Schwär, G., Grossmann, T., Müller, S.C., Hart, M., Haas, J., Galata, V., Müller, I., Fehlmann, T., Eichler, H., Franke, A., Meder, B., Meese, E., Hoth, M., Keller, A.
"Deep characterization of blood cell miRNomes by NGS"
Cell Mol Life Sci 73, 3169-3181, (2016), DOI:10.1007/s00018-016-2154-9, Pubmed-ID: 26874686.

Hoth, M.
"CRAC channels, calcium, and cancer in light of the driver and passenger concept"
Biochim Biophys Acta 1863, 1408-1417, (2016), DOI:10.1016/j.bbamcr.2015.12.009, Pubmed-ID: 26705695.

Publications 2015

Frischauf, I., Zayats, V., Deix, M., Hochreiter, A., Jardin, I., Muik, M., Lackner, B., Svobodová, B., Pammer, T., Litviňuková, M., Sridhar, A.A., Derler, I., Bogeski, I., Romanin, C., Ettrich, R.H., Schindl, R.
"A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription"
Sci Signal 8, ra131-XXXXX, (2015), DOI:10.1126/scisignal.aab1901, Pubmed-ID: 26696631.

Khatri, Y., Hannemann, F., Girhard, M., Kappl, R., Hutter, M., Urlacher, V.B., Bernhardt, R.
"A natural heme-signature variant of CYP267A1 from Sorangium cellulosum So ce56 executes diverse ω-hydroxylation"
FEBS J 282, 74-88, (2015), DOI:10.1111/febs.13104, Pubmed-ID: 25302415.

Petrungaro, C., Zimmermann, K.M., Küttner, V., Fischer, M., Dengjel, J., Bogeski, I., Riemer, J.
"The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake"
Cell Metab 22, 721-733, (2015), DOI:10.1016/j.cmet.2015.08.019, Pubmed-ID: 26387864.

Holzmann, C., Kilch, T., Kappel, S., Dörr, K., Jung, V., Stöckle, M., Bogeski, I., Peinelt, C.
"Differential Redox Regulation of Ca²⁺ Signaling and Viability in Normal and Malignant Prostate Cells"
Biophys J 109, 1410-1419, (2015), DOI:10.1016/j.bpj.2015.08.006, Pubmed-ID: 26445441.

Nickel, A. G. , von Hardenberg, A., Hohl, M., Löffler, J.R., Kohlhaas, M., Becker, J., Reil, J., Kazakov, A., Bonnekoh, J., Stadelmaier, M., Puhl, S., Wagner, M., Bogeski, I., Cortassa, S., Kappl, R., Pasieka, B., Lafontaine, M., Lancaster, C.y.D., Blacker, T.S., Hall, A.R., Duchen, M.R., Kästner, L., Lipp, P., Zeller, T., Müller, C., Knopp, A., Laufs, U., Böhm, M., Hoth, M., Maack, C.
"Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure"
Cell Metab 22, 472-484, (2015), DOI:10.1016/j.cmet.2015.07.008, Pubmed-ID: 26256392.

Marshall, M. R. , Pattu, V., Halimani, M., Maier-Peuschel, M., Müller, M., Becherer, U., Hong, W., Hoth, M., Tschernig, T., Bryceson, Y.T., Rettig, J.
"VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity"
J Cell Biol 210, 135-151, (2015), DOI:10.1083/jcb.201411093, Pubmed-ID: 26124288.

Law, J. a. Y. , Susloparova, A., Vu, X.T., Zhou, X., Hempel, F., Qu, B., Hoth, M., Ingebrandt, S.
"Human T cells monitored by impedance spectrometry using field-effect transistor arrays: a novel tool for single-cell adhesion and migration studies"
Biosens Bioelectron 67, 170-176, (2015), DOI:10.1016/j.bios.2014.08.007, Pubmed-ID: 25155061.

Simeoni, L., Bogeski, I.
"Redox regulation of T-cell receptor signaling"
Biol Chem 396, 555-568, (2015), DOI:10.1515/hsz-2014-0312, Pubmed-ID: 25781677.

Miederer, A., Alansary, D., Schwär, G., Lee, P., Jung, M., Helms, V., Niemeyer, B.A.
"A STIM2 splice variant negatively regulates store-operated calcium entry"
Nat Commun 6, 6899-XXXX, (2015), DOI:10.1038/ncomms7899, Pubmed-ID: 25896806.

Yang, R., Pfütze, K., Zucknick, M., Sutter, C., Wappenschmidt, B., Marme, F., Qu, B., Cuk, K., Engel, C., Schott, S., Schneeweiss, A., Brenner, H., Claus, R., Plass, C., Bugert, P., Hoth, M., Sohn, C., Schmutzler, R., Bartram, C.R., Burwinkel, B.
"DNA methylation array analyses identified breast cancer-associated HYAL2 methylation in peripheral blood"
Int J Cancer 136, 1845-1855, (2015), DOI:10.1002/ijc.29205, Pubmed-ID: 25213452.

Diler, E., Saul, S., Bogeski, I., Meier, C., Tschernig, T.
"Influence of extracellular magnesium on phagocytosis and free cytosolic Mg levels in differentiated U937 and MH-S cells"
Magnes Res 28, 23-31, (2015), DOI:10.1684/mrh.2015.0378, Pubmed-ID: 25967881.

Alansary, D., Bogeski, I., Niemeyer, B.A.
"Facilitation of Orai3 targeting and store-operated function by Orai1"
Biochim Biophys Acta 1853, 1541-1550, (2015), DOI:10.1016/j.bbamcr.2015.03.007, Pubmed-ID: 25791427.

Cierlitza, M., Chauvistré, H., Bogeski, I., Zhang, X., Hauschild, A., Herlyn, M., Schadendorf, D., Vogt, T., Roesch, A.
"Mitochondrial oxidative stress as a novel therapeutic target to overcome intrinsic drug resistance in melanoma cell subpopulations"
Exp Dermatol 24, 155-157, (2015), DOI:10.1111/exd.12613, Pubmed-ID: 25453510.

Bufe, B., Schumann, T., Kappl, R., Bogeski, I., Kummerow, C., Podgórska, M., Smola, S., Hoth, M., Zufall, F.
"Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a new mechanism for sensing pathogens"
J Biol Chem 290, 7369-7387, (2015), DOI:10.1074/jbc.M114.626747, Pubmed-ID: 25605714.

Publications 2014

Ermakova, Y. G. , Bilan, D.S., Matlashov, M.E., Mishina, N.M., Markvicheva, K.N., Subach, O.M., Subach, F.V., Bogeski, I., Hoth, M., Enikolopov, G., Belousov, V.V.
"Red fluorescent genetically encoded indicator for intracellular hydrogen peroxide"
Nat Commun 5, 5222-XXXX, (2014), DOI:10.1038/ncomms6222, Pubmed-ID: 25330925.

Bogeski, I., Niemeyer, B.A.
"Redox regulation of ion channels"
Antioxid Redox Signal 21, 859-862, (2014), DOI:10.1089/ars.2014.6019, Pubmed-ID: 24930772.

Alansary, D., Kilch, T., Holzmann, C., Peinelt, C., Hoth, M., Lis, A.
"Patch-clamp measurement of ICRAC and ORAI channel activity"
Cold Spring Harb Protoc 2014, 602-607, (2014), DOI:10.1101/pdb.top066795, Pubmed-ID: 24890214.

Alansary, D., Kilch, T., Holzmann, C., Peinelt, C., Hoth, M., Lis, A.
"The minimal requirements to use calcium imaging to analyze ICRAC"
Cold Spring Harb Protoc 2014, 638-642, (2014), DOI:10.1101/pdb.prot073262, Pubmed-ID: 24890204.

Alansary, D., Kilch, T., Holzmann, C., Peinelt, C., Hoth, M., Lis, A.
"Measuring endogenous ICRAC and ORAI currents with the patch-clamp technique"
Cold Spring Harb Protoc 2014, 630-637, (2014), DOI:10.1101/pdb.prot073254, Pubmed-ID: 24890203.

Kummerow, C., Schwarz, E.C., Bufe, B., Zufall, F., Hoth, M., Qu, B.
"A simple, economic, time-resolved killing assay"
Eur J Immunol 44, 1870-1872, (2014), DOI:10.1002/eji.201444518, Pubmed-ID: 24599783.

Stanisz, H., Saul, S., Müller, C.S.L., Kappl, R., Niemeyer, B.A., Vogt, T., Hoth, M., Roesch, A., Bogeski, I.
"Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry"
Pigment Cell Melanoma Res 27, 442-453, (2014), DOI:10.1111/pcmr.12222, Pubmed-ID: 24472175.

Saul, S., Stanisz, H., Backes, C.S., Schwarz, E.C., Hoth, M.
"How ORAI and TRP channels interfere with each other: interaction models and examples from the immune system and the skin"
Eur J Pharmacol 739, 49-59, (2014), DOI:10.1016/j.ejphar.2013.10.071, Pubmed-ID: 24291108.

Thierbach, S., Bui, N., Zapp, J., Chhabra, S.R., Kappl, R., Fetzner, S.
"Substrate-assisted O2 activation in a cofactor-independent dioxygenase"
Chem Biol 21, 217-225, (2014), DOI:10.1016/j.chembiol.2013.11.013, Pubmed-ID: 24388758.

Halimani, M., Pattu, V., Marshall, M.R., Chang, H.F., Matti, U., Jung, M., Becherer, U., Krause, E., Hoth, M., Schwarz, E.C., Rettig, J.
"Syntaxin11 serves as a t-SNARE for the fusion of lytic granules in human cytotoxic T lymphocytes"
Eur J Immunol 44, 573-584, (2014), DOI:10.1002/eji.201344011, Pubmed-ID: 24227526.

Publications 2013

Mirceski, V., Gulaboski, R., Lovric, M., Bogeski, I., Kappl, R., Hoth, M.
"Square-Wave Voltammetry: A Review on the Recent Progress"
Electroanalysis 25, 2411-2422, (2013), DOI:https://doi.org/10.1002/elan.201300369.

Holzmann, C., Kilch, T., Kappel, S., Armbrüster, A., Jung, V., Stöckle, M., Bogeski, I., Schwarz, E.C., Peinelt, C.
"ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer"
Oncotarget 4, 2096-2107, (2013), DOI:10.18632/oncotarget.1483, Pubmed-ID: 24240085.

Shaw, P. J. , Qu, B., Hoth, M., Feske, S.
"Molecular regulation of CRAC channels and their role in lymphocyte function"
Cell Mol Life Sci 70, 2637-2656, (2013), DOI:10.1007/s00018-012-1175-2, Pubmed-ID: 23052215.

Schwarz, E. C. , Qu, B., Hoth, M.
"Calcium, cancer and killing: the role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells"
Biochim Biophys Acta 1833, 1603-1611, (2013), DOI:10.1016/j.bbamcr.2012.11.016, Pubmed-ID: 23220009.

Dudenhöffer-Pfeifer, M., Schirra, C., Pattu, V., Halimani, M., Maier-Peuschel, M., Marshall, M.R., Matti, U., Becherer, U., Dirks, J., Jung, M., Lipp, P., Hoth, M., Sester, M., Krause, E., Rettig, J.
"Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes"
Traffic 14, 798-809, (2013), DOI:10.1111/tra.12074, Pubmed-ID: 23590328.

Roesch, A., Vultur, A., Bogeski, I., Wang, H., Zimmermann, K.M., Speicher, D., Körbel, C., Laschke, M.W., Gimotty, P.A., Philipp, S.E., Krause, E., Pätzold, S., Villanueva, J., Krepler, C., Fukunaga-Kalabis, M., Hoth, M., Bastian, B.C., Vogt, T., Herlyn, M.
"Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells"
Cancer Cell 23, 811-825, (2013), DOI:10.1016/j.ccr.2013.05.003, Pubmed-ID: 23764003.

Gulaboski, R., Bogeski, I., Mirčeski, V., Saul, S., Pasieka, B., Haeri, H.H., Stefova, M., Stanoeva, J.P., Mitrev, S., Hoth, M., Kappl, R.
"Hydroxylated derivatives of dimethoxy-1,4-benzoquinone as redox switchable earth-alkaline metal ligands and radical scavengers"
Sci Rep 3, 1865-XXXX, (2013), DOI:10.1038/srep01865, Pubmed-ID: 23689559.

Yao, W., Cai, X., Liu, C., Qin, Y., Cheng, H., Ji, S., Xu, W., Wu, C., Chen, T., Xu, J., Long, J., Fang, Z., Qu, B., Hoth, M., Ni, Q., Zha, X., Yu, X.
"Profilin 1 potentiates apoptosis induced by staurosporine in cancer cells"
Curr Mol Med 13, 417-428, (2013), Pubmed-ID: 23331014.

Carreras-Sureda, A., Cantero-Recasens, G., Rubio-Moscardo, F., Kiefer, K., Peinelt, C., Niemeyer, B.A., Valverde, M.A., Vicente, R.
"ORMDL3 modulates store-operated calcium entry and lymphocyte activation"
Hum Mol Genet 22, 519-530, (2013), DOI:10.1093/hmg/dds450, Pubmed-ID: 23100328.

Hoth, M., Niemeyer, B.A.
"The neglected CRAC proteins: Orai2, Orai3, and STIM2"
Curr Top Membr 71, 237-271, (2013), DOI:10.1016/B978-0-12-407870-3.00010-X, Pubmed-ID: 23890118.

Kilch, T., Alansary, D., Peglow, M., Dörr, K., Rychkov, G., Rieger, H., Peinelt, C., Niemeyer, B.A.
"Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1"
J Biol Chem 288, 1653-1664, (2013), DOI:10.1074/jbc.M112.417246, Pubmed-ID: 23212906.

Publications 2012

Bogeski, I., Kilch, T., Niemeyer, B.A.
"ROS and SOCE: recent advances and controversies in the regulation of STIM and Orai"
J Physiol 590, 4193-4200, (2012), DOI:10.1113/jphysiol.2012.230565, Pubmed-ID: 22615429.

Gulaboski, R., Mirčeski, V., Bogeski, I., Hoth, M.
"Protein film voltammetry: electrochemical enzymatic spectroscopy. A review on recent progress"
Journal of Solid State Electrochemistry 16, 2315-2328, (2012), DOI:10.1007/s10008-011-1397-5.

Mishina, N. M. , Bogeski, I., Bolotin, D.A., Hoth, M., Niemeyer, B.A., Schultz, C., Zagaynova, E.V., Lukyanov, S., Belousov, V.V.
"Can we see PIP(3) and hydrogen peroxide with a single probe?"
Antioxid Redox Signal 17, 505-512, (2012), DOI:10.1089/ars.2012.4574, Pubmed-ID: 22369174.

Quintana, A., Hoth, M.
"Mitochondrial dynamics and their impact on T cell function"
Cell Calcium 52, 57-63, (2012), DOI:10.1016/j.ceca.2012.02.005, Pubmed-ID: 22425631.

Stanisz, H., Stark, A., Kilch, T., Schwarz, E.C., Müller, C.S.L., Peinelt, C., Hoth, M., Niemeyer, B.A., Vogt, T., Bogeski, I.
"ORAI1 Ca(2+) channels control endothelin-1-induced mitogenesis and melanogenesis in primary human melanocytes"
J Invest Dermatol 132, 1443-1451, (2012), DOI:10.1038/jid.2011.478, Pubmed-ID: 22318387.

Schirmer, S. H. , Degen, A., Baumhäkel, M., Custodis, F., Schuh, L., Kohlhaas, M., Friedrich, E., Bahlmann, F., Kappl, R., Maack, C., Böhm, M., Laufs, U.
"Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis"
Eur Heart J 33, 1223-1231, (2012), DOI:10.1093/eurheartj/ehr255, Pubmed-ID: 21821843.

Pattu, V., Qu, B., Schwarz, E.C., Strauss, B., Weins, L., Bhat, S.S., Halimani, M., Marshall, M., Rettig, J., Hoth, M.
"SNARE protein expression and localization in human cytotoxic T lymphocytes"
Eur J Immunol 42, 470-475, (2012), DOI:10.1002/eji.201141915, Pubmed-ID: 22120889.

Publications 2011

Hötzer, B., Ivanov, R., Altmeier, S., Kappl, R., Jung, G.
"Determination of copper(II) ion concentration by lifetime measurements of green fluorescent protein"
J Fluoresc 21, 2143-2153, (2011), DOI:10.1007/s10895-011-0916-1, Pubmed-ID: 21773693.

Niemeyer, B. A. , Hoth, M.
"Excitable T cells: Ca(v)1.4 channel contributions and controversies"
Immunity 35, 315-317, (2011), DOI:10.1016/j.immuni.2011.09.001, Pubmed-ID: 21943485.

Bogeski, I., Kappl, R., Kummerow, C., Gulaboski, R., Hoth, M., Niemeyer, B.A.
"Redox regulation of calcium ion channels: chemical and physiological aspects"
Cell Calcium 50, 407-423, (2011), DOI:10.1016/j.ceca.2011.07.006, Pubmed-ID: 21930299.

Iwasaki, T., Kappl, R., Bracic, G., Shimizu, N., Ohmori, D., Kumasaka, T.
"ISC-like [2Fe-2S] ferredoxin (FdxB) dimer from Pseudomonas putida JCM 20004: structural and electron-nuclear double resonance characterization"
J Biol Inorg Chem 16, 923-935, (2011), DOI:10.1007/s00775-011-0793-8, Pubmed-ID: 21647778.

Quintana, A., Pasche, M., Junker, C., Al-Ansary, D., Rieger, H., Kummerow, C., Nuñez, L., Villalobos, C., Meraner, P., Becherer, U., Rettig, J., Niemeyer, B.A., Hoth, M.
"Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation"
EMBO J 30, 3895-3912, (2011), DOI:10.1038/emboj.2011.289, Pubmed-ID: 21847095.

Müller, J. J. , Hannemann, F., Schiffler, B., Ewen, K.M., Kappl, R., Heinemann, U., Bernhardt, R.
"Structural and thermodynamic characterization of the adrenodoxin-like domain of the electron-transfer protein Etp1 from Schizosaccharomyces pombe"
J Inorg Biochem 105, 957-965, (2011), DOI:10.1016/j.jinorgbio.2011.04.001, Pubmed-ID: 21536008.

Pattu, V., Qu, B., Marshall, M., Becherer, U., Junker, C., Matti, U., Schwarz, E.C., Krause, E., Hoth, M., Rettig, J.
"Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes"
Traffic 12, 890-901, (2011), DOI:10.1111/j.1600-0854.2011.01193.x, Pubmed-ID: 21438968.

Bogeski, I., Gulaboski, R., Kappl, R., Mirceski, V., Stefova, M., Petreska, J., Hoth, M.
"Calcium binding and transport by coenzyme Q"
J Am Chem Soc 133, 9293-9303, (2011), DOI:10.1021/ja110190t, Pubmed-ID: 21548646.

Qu, B., Pattu, V., Junker, C., Schwarz, E.C., Bhat, S.S., Kummerow, C., Marshall, M., Matti, U., Neumann, F., Pfreundschuh, M., Becherer, U., Rieger, H., Rettig, J., Hoth, M.
"Docking of lytic granules at the immunological synapse in human CTL requires Vti1b-dependent pairing with CD3 endosomes"
J Immunol 186, 6894-6904, (2011), DOI:10.4049/jimmunol.1003471, Pubmed-ID: 21562157.

Qu, B., Al-Ansary, D., Kummerow, C., Hoth, M., Schwarz, E.C.
"ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance"
Cell Calcium 50, 261-269, (2011), DOI:10.1016/j.ceca.2011.05.015, Pubmed-ID: 21665274.

Muñoz, E., Valero, R.A., Quintana, A., Hoth, M., Núñez, L., Villalobos, C.
"Nonsteroidal anti-inflammatory drugs inhibit vascular smooth muscle cell proliferation by enabling the Ca2+-dependent inactivation of calcium release-activated calcium/orai channels normally prevented by mitochondria"
J Biol Chem 286, 16186-16196, (2011), DOI:10.1074/jbc.M110.198952, Pubmed-ID: 21402693.

Junker, C., Hoth, M.
"Immune synapses: mitochondrial morphology matters"
EMBO J 30, 1187-1189, (2011), DOI:10.1038/emboj.2011.72, Pubmed-ID: 21468096.

Wenning, A. S. , Neblung, K., Strauss, B., Wolfs, M., Sappok, A., Hoth, M., Schwarz, E.C.
"TRP expression pattern and the functional importance of TRPC3 in primary human T-cells"
Biochim Biophys Acta 1813, 412-423, (2011), DOI:10.1016/j.bbamcr.2010.12.022, Pubmed-ID: 21215279.

Publications 2010

Spohn, D., Rössler, O.G., Philipp, S.E., Raubuch, M., Kitajima, S., Griesemer, D., Hoth, M., Thiel, G.
"Thapsigargin induces expression of activating transcription factor 3 in human keratinocytes involving Ca2+ ions and c-Jun N-terminal protein kinase"
Mol Pharmacol 78, 865-876, (2010), DOI:10.1124/mol.110.067637, Pubmed-ID: 20713550.

Bogeski, I., Al-Ansary, D., Qu, B., Niemeyer, B.A., Hoth, M., Peinelt, C.
"Pharmacology of ORAI channels as a tool to understand their physiological functions"
Expert Rev Clin Pharmacol 3, 291-303, (2010), DOI:10.1586/ecp.10.23, Pubmed-ID: 22111611.

Bogeski, I., Kummerow, C., Al-Ansary, D., Schwarz, E.C., Koehler, R., Kozai, D., Takahashi, N., Peinelt, C., Griesemer, D., Bozem, M., Mori, Y., Hoth, M., Niemeyer, B.A.
"Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling"
Sci Signal 3, ra24-XXXX, (2010), DOI:10.1126/scisignal.2000672, Pubmed-ID: 20354224.

Schwindling, C., Quintana, A., Krause, E., Hoth, M.
"Mitochondria positioning controls local calcium influx in T cells"
J Immunol 184, 184-190, (2010), DOI:10.4049/jimmunol.0902872, Pubmed-ID: 19949095.

Thiel, M., Wolfs, M., Bauer, S., Wenning, A.S., Burckhart, T., Schwarz, E.C., Scott, A.M., Renner, C., Hoth, M.
"Efficiency of T-cell costimulation by CD80 and CD86 cross-linking correlates with calcium entry"
Immunology 129, 28-40, (2010), DOI:10.1111/j.1365-2567.2009.03155.x, Pubmed-ID: 19824921.

Al-Ansary, D., Bogeski, I., Disteldorf, B.M.J., Becherer, U., Niemeyer, B.A.
"ATP modulates Ca2+ uptake by TRPV6 and is counteracted by isoform-specific phosphorylation"
FASEB J 24, 425-435, (2010), DOI:10.1096/fj.09-141481, Pubmed-ID: 19805577.

Publications 2009

Kummerow, C., Junker, C., Kruse, K., Rieger, H., Quintana, A., Hoth, M.
"The immunological synapse controls local and global calcium signals in T lymphocytes"
Immunol Rev 231, 132-147, (2009), DOI:10.1111/j.1600-065X.2009.00811.x, Pubmed-ID: 19754894.

Quintana, A., Kummerow, C., Junker, C., Becherer, U., Hoth, M.
"Morphological changes of T cells following formation of the immunological synapse modulate intracellular calcium signals"
Cell Calcium 45, 109-122, (2009), DOI:10.1016/j.ceca.2008.07.003, Pubmed-ID: 18789821.

Publications 2008

Gulaboski, R., Lovrić, M., Mirceski, V., Bogeski, I., Hoth, M.
"A new rapid and simple method to determine the kinetics of electrode reactions of biologically relevant compounds from the half-peak width of the square-wave voltammograms"
Biophys Chem 138, 130-137, (2008), DOI:10.1016/j.bpc.2008.09.015, Pubmed-ID: 18929440.

Merkens, H., Kappl, R., Jakob, R.P., Schmid, F.X., Fetzner, S.
"Quercetinase QueD of Streptomyces sp. FLA, a monocupin dioxygenase with a preference for nickel and cobalt"
Biochemistry 47, 12185-12196, (2008), DOI:10.1021/bi801398x, Pubmed-ID: 18950192.

Gulaboski, R., Lovrić, M., Mirceski, V., Bogeski, I., Hoth, M.
"Protein-film voltammetry: a theoretical study of the temperature effect using square-wave voltammetry"
Biophys Chem 137, 49-55, (2008), DOI:10.1016/j.bpc.2008.06.011, Pubmed-ID: 18657347.

Gulaboski, R., Pereira, C.M., Cordeiro, M.a.D.S., Silva, A.F., Hoth, M., Bogeski, I.
"Redox properties of the calcium chelator Fura-2 in mimetic biomembranes"
Cell Calcium 43, 615-621, (2008), DOI:10.1016/j.ceca.2007.10.002, Pubmed-ID: 18001832.

Bogeski, I., Mirceski, V., Hoth, M.
"Probing the redox activity of T-lymphocytes deposited at electrode surfaces with voltammetric methods"
Clin Chem Lab Med 46, 197-203, (2008), DOI:10.1515/CCLM.2008.023, Pubmed-ID: 18076353.

Fanger, C. M. , Zweifach, A., Dolmetsch, R.E., Hoth, M., Lewis, R.S.
"Function Follows Form: The Role of Store-Operated Calcium Channels in T-Cell Activation"
Cellular Physiology and Biochemistry 7, 203-218, (2008), DOI:10.1159/000154875.

Publications 2007

Schwarz, E. C. , Kummerow, C., Wenning, A.S., Wagner, K., Sappok, A., Waggershauser, K., Griesemer, D., Strauss, B., Wolfs, M., Quintana, A., Hoth, M.
"Calcium dependence of T cell proliferation following focal stimulation"
Eur J Immunol 37, 2723-2733, (2007), DOI:10.1002/eji.200737039, Pubmed-ID: 17899547.

Quintana, A., Schwindling, C., Wenning, A.S., Becherer, U., Rettig, J., Schwarz, E.C., Hoth, M.
"T cell activation requires mitochondrial translocation to the immunological synapse"
Proc Natl Acad Sci U S A 104, 14418-14423, (2007), DOI:10.1073/pnas.0703126104, Pubmed-ID: 17726106.

Mueller, P., Quintana, A., Griesemer, D., Hoth, M., Pieters, J.
"Disruption of the cortical actin cytoskeleton does not affect store operated Ca2+ channels in human T-cells"
FEBS Lett 581, 3557-3562, (2007), DOI:10.1016/j.febslet.2007.06.068, Pubmed-ID: 17624329.

Stefano, L., Rössler, O.G., Griesemer, D., Hoth, M., Thiel, G.
"P2X(7) receptor stimulation upregulates Egr-1 biosynthesis involving a cytosolic Ca(2+) rise, transactivation of the EGF receptor and phosphorylation of ERK and Elk-1"
J Cell Physiol 213, 36-44, (2007), DOI:10.1002/jcp.21085, Pubmed-ID: 17474086.

Mirčeski, V., Gulaboski, R., Bogeski, I., Hoth, M.
"Redox Chemistry of Ca-Transporter 2-Palmitoylhydroquinone in an Artificial Thin Organic Film Membrane"
J. Phys. Chem. C 111, 6068-6076, (2007), DOI:10.1021/jp068600t.

Gulaboski, R., Cordeiro, M.a.D.S., Milhazes, N., Garrido, J., Borges, F., Jorge, M., Pereira, C.M., Bogeski, I., Morales, A.H., Naumoski, B., Silva, A.F.
"Evaluation of the lipophilic properties of opioids, amphetamine-like drugs, and metabolites through electrochemical studies at the interface between two immiscible solutions"
Anal Biochem 361, 236-243, (2007), DOI:10.1016/j.ab.2006.11.006, Pubmed-ID: 17178092.

Schwarz, E. C. , Wolfs, M.J., Tonner, S., Wenning, A.S., Quintana, A., Griesemer, D., Hoth, M.
"TRP channels in lymphocytes"
Handb Exp Pharmacol, 445-456, (2007), DOI:10.1007/978-3-540-34891-7_26, Pubmed-ID: 17217072.

Publications 2006

Quintana, A., Schwarz, E.C., Schwindling, C., Lipp, P., Kaestner, L., Hoth, M.
"Sustained activity of calcium release-activated calcium channels requires translocation of mitochondria to the plasma membrane"
J Biol Chem 281, 40302-40309, (2006), DOI:10.1074/jbc.M607896200, Pubmed-ID: 17056596.

Griesemer, D., Löffler, B., Kummerow, C., Quintana, A., Schwarz, E.C., Hoth, M.
"Calcium release-activated calcium channels as signal transducers in T-cells"
Signal Transduction 6, 233-239, (2006), DOI:10.1002/sita.200600092.

Schwarz, E. C. , Wissenbach, U., Niemeyer, B.A., Strauss, B., Philipp, S.E., Flockerzi, V., Hoth, M.
"TRPV6 potentiates calcium-dependent cell proliferation"
Cell Calcium 39, 163-173, (2006), DOI:10.1016/j.ceca.2005.10.006, Pubmed-ID: 16356545.

Publications 2005

Quintana, A., Griesemer, D., Schwarz, E.C., Hoth, M.
"Calcium-dependent activation of T-lymphocytes"
Pflugers Arch 450, 1-12, (2005), DOI:10.1007/s00424-004-1364-4, Pubmed-ID: 15806400.

Publications 2004

Tutsch, E., Griesemer, D., Schwarz, A., Stallmach, A., Hoth, M.
"Two-photon analysis of calcium signals in T lymphocytes of intact lamina propria from human intestine"
Eur J Immunol 34, 3477-3484, (2004), DOI:10.1002/eji.200425265, Pubmed-ID: 15495161.

Quintana, A., Hoth, M.
"Apparent cytosolic calcium gradients in T-lymphocytes due to fura-2 accumulation in mitochondria"
Cell Calcium 36, 99-109, (2004), DOI:10.1016/j.ceca.2004.01.003, Pubmed-ID: 15193858.

Zitt, C., Strauss, B., Schwarz, E.C., Spaeth, N., Rast, G., Hatzelmann, A., Hoth, M.
"Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2"
J Biol Chem 279, 12427-12437, (2004), DOI:10.1074/jbc.M309297200, Pubmed-ID: 14718545.

Schwarz, A., Tutsch, E., Ludwig, B., Schwarz, E.C., Stallmach, A., Hoth, M.
"Ca2+ signaling in identified T-lymphocytes from human intestinal mucosa. Relation to hyporeactivity, proliferation, and inflammatory bowel disease"
J Biol Chem 279, 5641-5647, (2004), DOI:10.1074/jbc.M309317200, Pubmed-ID: 14585840.

Griesemer, D., Quintana, A., Mery, L., Schwarz, E., Hoth, M.
"Calcium transport in T-lymphocytes"
Nova Acta Leopoldina 89, 75-80, (2004), DOI:10.26164/leopoldina_10_00986.

Publications 2003

Philipp, S., Strauss, B., Hirnet, D., Wissenbach, U., Mery, L., Flockerzi, V., Hoth, M.
"TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes"
J Biol Chem 278, 26629-26638, (2003), DOI:10.1074/jbc.M304044200, Pubmed-ID: 12736256.

Publications 2002

Bautista, D. M. , Hoth, M., Lewis, R.S.
"Enhancement of calcium signalling dynamics and stability by delayed modulation of the plasma-membrane calcium-ATPase in human T cells"
J Physiol 541, 877-894, (2002), DOI:10.1113/jphysiol.2001.016154, Pubmed-ID: 12068047.

Mery, L., Strauss, B., Dufour, J.F., Krause, K.H., Hoth, M.
"The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells"
J Cell Sci 115, 3497-3508, (2002), DOI:10.1242/jcs.115.17.3497, Pubmed-ID: 12154080.

Held, B., Freise, D., Freichel, M., Hoth, M., Flockerzi, V.
"Skeletal muscle L-type Ca(2+) current modulation in gamma1-deficient and wildtype murine myotubes by the gamma1 subunit and cAMP"
J Physiol 539, 459-468, (2002), DOI:10.1113/jphysiol.2001.012745, Pubmed-ID: 11882678.

Publications 2001

Niemeyer, B. A. , Mery, L., Zawar, C., Suckow, A., Monje, F., Pardo, L.A., Stuhmer, W., Flockerzi, V., Hoth, M.
"Ion channels in health and disease. 83rd Boehringer Ingelheim Fonds International Titisee Conference"
EMBO Rep 2, 568-573, (2001), DOI:10.1093/embo-reports/kve145, Pubmed-ID: 11463739.

Publications 2000

Hoth, M., Button, D.C., Lewis, R.S.
"Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes"
Proc Natl Acad Sci U S A 97, 10607-10612, (2000), DOI:10.1073/pnas.180143997, Pubmed-ID: 10973476.

Philipp, S., Trost, C., Warnat, J., Rautmann, J., Himmerkus, N., Schroth, G., Kretz, O., Nastainczyk, W., Cavalie, A., Hoth, M., Flockerzi, V.
"TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like channels in adrenal cells"
J Biol Chem 275, 23965-23972, (2000), DOI:10.1074/jbc.M003408200, Pubmed-ID: 10816590.

Freise, D., Held, B., Wissenbach, U., Pfeifer, A., Trost, C., Himmerkus, N., Schweig, U., Freichel, M., Biel, M., Hofmann, F., Hoth, M., Flockerzi, V.
"Absence of the gamma subunit of the skeletal muscle dihydropyridine receptor increases L-type Ca2+ currents and alters channel inactivation properties"
J Biol Chem 275, 14476-14481, (2000), DOI:10.1074/jbc.275.19.14476, Pubmed-ID: 10799530.

Publications 1999

Hoth, M., Lewis, R.S.
"Monitoring intra-mitochondrial calcium concentration with rhod-2"
In "Imaging Neurones", eds. Yuste R, LAnni F, Konnerth A, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 39.1-39.14, (1999).

Zweifach, A., Hoth, M., Lewis, R.S.
"Simultanous measurements of membrane current and intracellular calciu"
In "Advanced Imaging Techniques", eds. Fasolato C, Rizzuto R, Springer Verlag, Hamburg, (1999).

Publications 1998

Hoth, M., Lewis, R.S.
"The fate of calcium ions entering a cell"
In "Integrative Aspects of Calcium Signaling", eds. Verkhratsky A. & Toescu E., Plenum Press, New York, 23-33, (1998).

Publications 1997

Hoth, M., Fanger, C.M., Lewis, R.S.
"Mitochondrial regulation of store-operated calcium signaling in T lymphocytes"
J Cell Biol 137, 633-648, (1997), DOI:10.1083/jcb.137.3.633, Pubmed-ID: 9151670.

Suda, N., Franzius, D., Fleig, A., Nishimura, S., Bödding, M., Hoth, M., Takeshima, H., Penner, R.
"Ca2+-induced Ca2+ release in Chinese hamster ovary (CHO) cells co-expressing dihydropyridine and ryanodine receptors"
J Gen Physiol 109, 619-631, (1997), DOI:10.1085/jgp.109.5.619, Pubmed-ID: 9154908.

Niemeyer, B., Fanger, C.M., Hoth, S., Hoth, M.
"Diversity of calcium entry mechanisms and their roles in cell signaling"
Futura 12, 11-19, (1997).

Publications 1996

Hoth, M.
"Depletion of intracellular calcium stores activates an outward potassium current in mast and RBL-1 cells that is correlated with CRAC channel activation"
FEBS Lett 390, 285-288, (1996), DOI:10.1016/0014-5793(96)00673-4, Pubmed-ID: 8706878.

Publications 1995

Fanger, C. M. , Hoth, M., Crabtree, G.R., Lewis, R.S.
"Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels"
J Cell Biol 131, 655-667, (1995), DOI:10.1083/jcb.131.3.655, Pubmed-ID: 7593187.

Hoth, M.
"Calcium and barium permeation through calcium release-activated calcium (CRAC) channels"
Pflugers Arch 430, 315-322, (1995), DOI:10.1007/BF00373905, Pubmed-ID: 7491254.

Publications 1994

Franzius, D., Hoth, M., Penner, R.
"Non-specific effects of calcium entry antagonists in mast cells"
Pflugers Arch 428, 433-438, (1994), DOI:10.1007/BF00374562, Pubmed-ID: 7838664.

Publications 1993

Hoth, M., Fasolato, C., Penner, R.
"Ion channels and calcium signaling in mast cells"
Ann N Y Acad Sci 707, 198-209, (1993), DOI:10.1111/j.1749-6632.1993.tb38053.x, Pubmed-ID: 9137553.

Fasolato, C., Hoth, M., Penner, R.
"A GTP-dependent step in the activation mechanism of capacitative calcium influx"
J Biol Chem 268, 20737-20740, (1993), Pubmed-ID: 8407897.

Penner, R., Fasolato, C., Hoth, M.
"Calcium influx and its control by calcium release"
Curr Opin Neurobiol 3, 368-374, (1993), DOI:10.1016/0959-4388(93)90130-q, Pubmed-ID: 8396477.

Hoth, M., Penner, R.
"Calcium release-activated calcium current in rat mast cells"
J Physiol 465, 359-386, (1993), DOI:10.1113/jphysiol.1993.sp019681, Pubmed-ID: 8229840.

Fasolato, C., Hoth, M., Penner, R.
"Multiple mechanisms of manganese-induced quenching of fura-2 fluorescence in rat mast cells"
Pflugers Arch 423, 225-231, (1993), DOI:10.1007/BF00374399, Pubmed-ID: 8321625.

Fasolato, C., Hoth, M., Matthews, G., Penner, R.
"Ca2+ and Mn2+ influx through receptor-mediated activation of nonspecific cation channels in mast cells"
Proc Natl Acad Sci U S A 90, 3068-3072, (1993), DOI:10.1073/pnas.90.7.3068, Pubmed-ID: 7681994.

Publications 1992

Hoth, M., Penner, R.
"Depletion of intracellular calcium stores activates a calcium current in mast cells"
Nature 355, 353-356, (1992), DOI:10.1038/355353a0, Pubmed-ID: 1309940.

Publications 1991

Stocker, M., Pongs, O., Hoth, M., Heinemann, S.H., Stühmer, W., Schröter, K.H., Ruppersberg, J.P.
"Swapping of functional domains in voltage-gated K+ channels"
Proc Biol Sci 245, 101-107, (1991), DOI:10.1098/rspb.1991.0094, Pubmed-ID: 1682932.

Univ.-Prof. Dr.
Markus Hoth

Phone:	+49 6841/16-16303
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Secretary

Regine Kaleja

Phone:	+49 6841/16-16300
Fax:	+49 6841/16-16302
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Any inquiry regarding teaching:
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