Hearing Physiology

Wadle, S. L. , Schmitt, T.T.X., Engel, J., Kurt, S., Hirtz, J.J.
"Altered population activity and local tuning heterogeneity in auditory cortex of Cacna2d3-deficient mice"
Biol Chem, , , (2022). DOI:10.1515/hsz-2022-0269., Pubmed-ID: 36342370
 

Bracic, G., Hegmann, K., Engel, J., Kurt, S.
"Impaired Subcortical Processing of Amplitude-Modulated Tones in Mice Deficient for Cacna2d3, a Risk Gene for Autism Spectrum Disorders in Humans"
eNeuro, 9, ENEURO.0118-22.2022, (2022). DOI:10.1523/ENEURO.0118-22.2022., Pubmed-ID: 35410870
 

Marchetta, P., Möhrle, D., Eckert, P., Reimann, K., Wolter, S., Tolone, A., Lang, I., Wolters, M., Feil, R., Engel, J., Paquet-Durand, F., Kuhn, M., Knipper, M., Rüttiger, L.
"Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss"
Front Aging Neurosci, 12, 83-XX, (2020). DOI:10.3389/fnagi.2020.00083., Pubmed-ID: 32327991
 

Schade-Mann, T., Münkner, S., Eckrich, T., Engel, J.
"Calcium signaling in interdental cells during the critical developmental period of the mouse cochlea"
Hear Res, 389, 107913-XXXXXX, (2020). DOI:10.1016/j.heares.2020.107913., Pubmed-ID: 32120242
 

Ortner, N. J. , Pinggera, A., Hofer, N.T., Siller, A., Brandt, N., Raffeiner, A., Vilusic, K., Lang, I., Blum, K., Obermair, G.J., Stefan, E., Engel, J., Striessnig, J.
"RBP2 stabilizes slow Cav1.3 Ca²⁺ channel inactivation properties of cochlear inner hair cells"
Pflugers Arch, 472, 3-25, (2020). DOI:10.1007/s00424-019-02338-4., Pubmed-ID: 31848688
 

Beggs, M. R. , Lee, J.J., Busch, K., Raza, A., Dimke, H., Weissgerber, P., Engel, J., Flockerzi, V., Alexander, R.T.
"TRPV6 and Ca_v1.3 Mediate Distal Small Intestine Calcium Absorption Before Weaning"
Cell Mol Gastroenterol Hepatol, 8, 625-642, (2019). DOI:10.1016/j.jcmgh.2019.07.005., Pubmed-ID: 31398491
 

Lang, I., Jung, M., Niemeyer, B.A., Ruth, P., Engel, J.
"Expression of the LRRC52 γ subunit (γ2) may provide Ca²⁺-independent activation of BK currents in mouse inner hair cells"
FASEB J, 33, 11721-11734, (2019). DOI:10.1096/fj.201900701RR., Pubmed-ID: 31348683
 

Stephani, F., Scheuer, V., Eckrich, T., Blum, K., Wang, W., Obermair, G.J., Engel, J.
"Deletion of the Ca²⁺ Channel Subunit α₂δ3 Differentially Affects Ca_v2.1 and Ca_v2.2 Currents in Cultured Spiral Ganglion Neurons Before and After the Onset of Hearing"
Front Cell Neurosci, 13, 278-XXX, (2019). DOI:10.3389/fncel.2019.00278., Pubmed-ID: 31293392
 

Eckrich, S., Hecker, D., Sorg, K., Blum, K., Fischer, K., Münkner, S., Wenzel, G., Schick, B., Engel, J.
"Cochlea-Specific Deletion of Ca_v1.3 Calcium Channels Arrests Inner Hair Cell Differentiation and Unravels Pitfalls of Conditional Mouse Models"
Front Cell Neurosci, 13, 225-XXX, (2019). DOI:10.3389/fncel.2019.00225., Pubmed-ID: 31178698
 

Ceriani, F., Hendry, A., Jeng, J., Johnson, S.L., Stephani, F., Olt, J., Holley, M.C., Mammano, F., Engel, J., Kros, C.J., Simmons, D.D., Marcotti, W.
"Coordinated calcium signalling in cochlear sensory and non-sensory cells refines afferent innervation of outer hair cells"
EMBO J, 38, e99839, (2019). DOI:10.15252/embj.201899839., Pubmed-ID: 30804003
 

Sonntag, M., Blosa, M., Schmidt, S., Reimann, K., Blum, K., Eckrich, T., Seeger, G., Hecker, D., Schick, B., Arendt, T., Engel, J., Morawski, M.
"Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets"
BMC Biol, 16, 99-XX, (2018). DOI:10.1186/s12915-018-0566-8., Pubmed-ID: 30253762
 

Eckrich, T., Blum, K., Milenkovic, I., Engel, J.
"Fast Ca²⁺ Transients of Inner Hair Cells Arise Coupled and Uncoupled to Ca²⁺ Waves of Inner Supporting Cells in the Developing Mouse Cochlea"
Front Mol Neurosci, 11, 264-XXX, (2018). DOI:10.3389/fnmol.2018.00264., Pubmed-ID: 30104958
 

Fell, B., Eckrich, S., Blum, K., Eckrich, T., Hecker, D., Obermair, G.J., Münkner, S., Flockerzi, V., Schick, B., Engel, J.
"α2δ2 Controls the Function and Trans-Synaptic Coupling of Cav1.3 Channels in Mouse Inner Hair Cells and Is Essential for Normal Hearing"
J Neurosci, 36, 11024-11036, (2016). DOI:10.1523/JNEUROSCI.3468-14.2016., Pubmed-ID: 27798183
 

Scharinger, A., Eckrich, S., Vandael, D.H., Schönig, K., Koschak, A., Hecker, D., Kaur, G., Lee, A., Sah, A., Bartsch, D., Benedetti, B., Lieb, A., Schick, B., Singewald, N., Sinnegger-Brauns, M.J., Carbone, E., Engel, J., Striessnig, J.
"Cell-type-specific tuning of Cav1.3 Ca(2+)-channels by a C-terminal automodulatory domain"
Front Cell Neurosci, 9, 309-XXX, (2015). DOI:10.3389/fncel.2015.00309., Pubmed-ID: 26379493
 

Pirone, A., Kurt, S., Zuccotti, A., Rüttiger, L., Pilz, P., Brown, D.H., Franz, C., Schweizer, M., Rust, M.B., Rübsamen, R., Friauf, E., Knipper, M., Engel, J.
"α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders"
J Neurosci, 34, 434-445, (2014). DOI:10.1523/JNEUROSCI.3085-13.2014., Pubmed-ID: 24403143
 

Nothwang, H., Engel, J., Knipper, M., Friauf, E.
"L-type calcium channels in the auditory system"
e-Neuroforum, 5, 60-66 (2014). DOI: doi:10.1007/s13295-014-0059-3
 

Dettling, J., Franz, C., Zimmermann, U., Lee, S.C., Bress, A., Brandt, N., Feil, R., Pfister, M., Engel, J., Flamant, F., Rüttiger, L., Knipper, M.
"Autonomous functions of murine thyroid hormone receptor TRα and TRβ in cochlear hair cells"
Mol Cell Endocrinol, 382, 26-37, (2014). DOI:10.1016/j.mce.2013.08.025., Pubmed-ID: 24012852
 

Duncker, S. V. , Franz, C., Kuhn, S., Schulte, U., Campanelli, D., Brandt, N., Hirt, B., Fakler, B., Blin, N., Ruth, P., Engel, J., Marcotti, W., Zimmermann, U., Knipper, M.
"Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells"
J Neurosci, 33, 9508-9519, (2013). DOI:10.1523/JNEUROSCI.5689-12.2013., Pubmed-ID: 23719817
 

Kurt, S., Sausbier, M., Rüttiger, L., Brandt, N., Moeller, C.K., Kindler, J., Sausbier, U., Zimmermann, U., van Straaten, H., Neuhuber, W., Engel, J., Knipper, M., Ruth, P., Schulze, H.
"Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing"
FASEB J, 26, 3834-3843, (2012). DOI:10.1096/fj.11-200535., Pubmed-ID: 22691916
 

Jaumann, M., Dettling, J., Gubelt, M., Zimmermann, U., Gerling, A., Paquet-Durand, F., Feil, S., Wolpert, S., Franz, C., Varakina, K., Xiong, H., Brandt, N., Kuhn, S., Geisler, H., Rohbock, K., Ruth, P., Schlossmann, J., Hütter, J., Sandner, P., Feil, R., Engel, J., Knipper, M., Rüttiger, L.
"cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function"
Nat Med, 18, 252-259, (2012). DOI:10.1038/nm.2634., Pubmed-ID: 22270721
 

Buerbank, S., Becker, K., Becker, C., Brandt, N., Engel, J., Knipper, M., Schick, B., Dlugaiczyk, J.
"Developmental regulation of glycine receptors at efferent synapses of the murine cochlea"
Histochem Cell Biol, 136, 387-398, (2011). DOI:10.1007/s00418-011-0855-6., Pubmed-ID: 21850450
 

El Ouardi, A., Streckert, J., Bitz, A., Münkner, S., Engel, J., Hansen, V.
"New fin-line devices for radiofrequency exposure of small biological samples in vitro allowing whole-cell patch clamp recordings"
Bioelectromagnetics, 32, 102-112, (2011). DOI:10.1002/bem.20621., Pubmed-ID: 21225887
 

Baig, S. M. , Koschak, A., Lieb, A., Gebhart, M., Dafinger, C., Nürnberg, G., Ali, A., Ahmad, I., Sinnegger-Brauns, M.J., Brandt, N., Engel, J., Mangoni, M.E., Farooq, M., Khan, H.U., Nürnberg, P., Striessnig, J., Bolz, H.J.
"Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness"
Nat Neurosci, 14, 77-84, (2011). DOI:10.1038/nn.2694., Pubmed-ID: 21131953
 

Gebhart, M., Juhasz-Vedres, G., Zuccotti, A., Brandt, N., Engel, J., Trockenbacher, A., Kaur, G., Obermair, G.J., Knipper, M., Koschak, A., Striessnig, J.
"Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule"
Mol Cell Neurosci, 44, 246-259, (2010). DOI:10.1016/j.mcn.2010.03.011., Pubmed-ID: 20363327
 

Johnson, S. L. , Franz, C., Kuhn, S., Furness, D.N., Rüttiger, L., Münkner, S., Rivolta, M.N., Seward, E.P., Herschman, H.R., Engel, J., Knipper, M., Marcotti, W.
"Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses"
Nat Neurosci, 13, 45-52, (2010). DOI:10.1038/nn.2456., Pubmed-ID: 20010821
 

Zampini, V., Johnson, S.L., Franz, C., Lawrence, N.D., Münkner, S., Engel, J., Knipper, M., Magistretti, J., Masetto, S., Marcotti, W.
"Elementary properties of CaV1.3 Ca(2+) channels expressed in mouse cochlear inner hair cells"
J Physiol, 588, 187-199, (2010). DOI:10.1113/jphysiol.2009.181917., Pubmed-ID: 19917569
 

Kuhn, S., Knirsch, M., Rüttiger, L., Kasperek, S., Winter, H., Freichel, M., Flockerzi, V., Knipper, M., Engel, J.
"Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits beta3 or beta4"
Channels (Austin), 3, 366-376, (2009). DOI:10.4161/chan.3.5.9774., Pubmed-ID: 19755851
 

Heidrych, P., Zimmermann, U., Kuhn, S., Franz, C., Engel, J., Duncker, S.V., Hirt, B., Pusch, C.M., Ruth, P., Pfister, M., Marcotti, W., Blin, N., Knipper, M.
"Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell"
Hum Mol Genet, 18, 2779-2790, (2009). DOI:10.1093/hmg/ddp213., Pubmed-ID: 19417007
 

Winter, H., Rüttiger, L., Müller, M., Kuhn, S., Brandt, N., Zimmermann, U., Hirt, B., Bress, A., Sausbier, M., Conscience, A., Flamant, F., Tian, Y., Zuo, J., Pfister, M., Ruth, P., Löwenheim, H., Samarut, J., Engel, J., Knipper, M.
"Deafness in TRbeta mutants is caused by malformation of the tectorial membrane"
J Neurosci, 29, 2581-2587, (2009). DOI:10.1523/JNEUROSCI.3557-08.2009., Pubmed-ID: 19244534
 

Johnson, S. L. , Forge, A., Knipper, M., Münkner, S., Marcotti, W.
"Tonotopic variation in the calcium dependence of neurotransmitter release and vesicle pool replenishment at mammalian auditory ribbon synapses"
J Neurosci, 28, 7670-7678, (2008). DOI:10.1523/JNEUROSCI.0785-08.2008., Pubmed-ID: 18650343
 

Engel, J.
"Gerbils can tune in"
J Physiol, 586, 919-XXX, (2008). DOI:10.1113/jphysiol.2007.150409., Pubmed-ID: 18287384
 

Singh, A., Gebhart, M., Fritsch, R., Sinnegger-Brauns, M.J., Poggiani, C., Hoda, J., Engel, J., Romanin, C., Striessnig, J., Koschak, A.
"Modulation of voltage- and Ca2+-dependent gating of CaV1.3 L-type calcium channels by alternative splicing of a C-terminal regulatory domain"
J Biol Chem, 283, 20733-20744, (2008). DOI:10.1074/jbc.M802254200., Pubmed-ID: 18482979
 

Tarabova, B., Lacinova, L., Engel, J.
"Effects of phenylalkylamines and benzothiazepines on Ca(v)1.3-mediated Ca2+ currents in neonatal mouse inner hair cells"
Eur J Pharmacol, 573, 39-48, (2007). DOI:10.1016/j.ejphar.2007.06.050., Pubmed-ID: 17651721
 

Knirsch, M., Brandt, N., Braig, C., Kuhn, S., Hirt, B., Münkner, S., Knipper, M., Engel, J.
"Persistence of Ca(v)1.3 Ca2+ channels in mature outer hair cells supports outer hair cell afferent signaling"
J Neurosci, 27, 6442-6451, (2007). DOI:10.1523/JNEUROSCI.5364-06.2007., Pubmed-ID: 17567805
 

Winter, H., Braig, C., Zimmermann, U., Engel, J., Rohbock, K., Knipper, M.
"Thyroid hormone receptor alpha1 is a critical regulator for the expression of ion channels during final differentiation of outer hair cells"
Histochem Cell Biol, 128, 65-75, (2007). DOI:10.1007/s00418-007-0294-6., Pubmed-ID: 17520268
 

Brandt, N., Kuhn, S., Münkner, S., Braig, C., Winter, H., Blin, N., Vonthein, R., Knipper, M., Engel, J.
"Thyroid hormone deficiency affects postnatal spiking activity and expression of Ca2+ and K+ channels in rodent inner hair cells"
J Neurosci, 27, 3174-3186, (2007). DOI:10.1523/JNEUROSCI.3965-06.2007., Pubmed-ID: 17376979
 

Schug, N., Braig, C., Zimmermann, U., Engel, J., Winter, H., Ruth, P., Blin, N., Pfister, M., Kalbacher, H., Knipper, M.
"Differential expression of otoferlin in brain, vestibular system, immature and mature cochlea of the rat"
Eur J Neurosci, 24, 3372-3380, (2006). DOI:10.1111/j.1460-9568.2006.05225.x., Pubmed-ID: 17229086
 

Engel, J., Braig, C., Rüttiger, L., Kuhn, S., Zimmermann, U., Blin, N., Sausbier, M., Kalbacher, H., Münkner, S., Rohbock, K., Ruth, P., Winter, H., Knipper, M.
"Two classes of outer hair cells along the tonotopic axis of the cochlea"
Neuroscience, 143, 837-849, (2006). DOI:10.1016/j.neuroscience.2006.08.060., Pubmed-ID: 17074442
 

Strutz-Seebohm, N., Seebohm, G., Fedorenko, O., Baltaev, R., Engel, J., Knirsch, M., Lang, F.
"Functional coassembly of KCNQ4 with KCNE-beta- subunits in Xenopus oocytes"
Cell Physiol Biochem, 18, 57-66, (2006). DOI:10.1159/000095158., Pubmed-ID: 16914890
 

Winter, H., Braig, C., Zimmermann, U., Geisler, H., Fränzer, J., Weber, T., Ley, M., Engel, J., Knirsch, M., Bauer, K., Christ, S., Walsh, E.J., McGee, J., Köpschall, I., Rohbock, K., Knipper, M.
"Thyroid hormone receptors TRalpha1 and TRbeta differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells"
J Cell Sci, 119, 2975-2984, (2006). DOI:10.1242/jcs.03013., Pubmed-ID: 16803873
 

Rüttiger, L., Sausbier, M., Zimmermann, U., Winter, H., Braig, C., Engel, J., Knirsch, M., Arntz, C., Langer, P., Hirt, B., Müller, M., Köpschall, I., Pfister, M., Münkner, S., Rohbock, K., Pfaff, I., Rüsch, A., Ruth, P., Knipper, M.
"Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss"
Proc Natl Acad Sci U S A, 101, 12922-12927, (2004). DOI:10.1073/pnas.0402660101., Pubmed-ID: 15328414
 

Michna, M., Knirsch, M., Hoda, J., Muenkner, S., Langer, P., Platzer, J., Striessnig, J., Engel, J.
"Cav1.3 (alpha1D) Ca2+ currents in neonatal outer hair cells of mice"
J Physiol, 553, 747-758, (2003). DOI:10.1113/jphysiol.2003.053256., Pubmed-ID: 14514878
 

Waka, N., Knipper, M., Engel, J.
"Localization of the calcium channel subunits Cav1.2 (alpha1C) and Cav2.3 (alpha1E) in the mouse organ of Corti"
Histol Histopathol, 18, 1115-1123, (2003). DOI:10.14670/HH-18.1115., Pubmed-ID: 12973680
 

Engel, J., Michna, M., Platzer, J., Striessnig, J.
"Calcium channels in mouse hair cells: function, properties and pharmacology"
Adv Otorhinolaryngol, 59, 35-41, (2002). DOI:10.1159/000059243., Pubmed-ID: 11885659
 

Koschak, A., Reimer, D., Huber, I., Grabner, M., Glossmann, H., Engel, J., Striessnig, J.
"alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages"
J Biol Chem, 276, 22100-22106, (2001). DOI:10.1074/jbc.M101469200., Pubmed-ID: 11285265
 

Platzer, J., Engel, J., Schrott-Fischer, A., Stephan, K., Bova, S., Chen, H., Zheng, H., Striessnig, J.
"Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels"
Cell, 102, 89-97, (2000). DOI:10.1016/s0092-8674(00)00013-1., Pubmed-ID: 10929716
 

Engel, J., Schultens, H.A., Schild, D.
"Small conductance potassium channels cause an activity-dependent spike frequency adaptation and make the transfer function of neurons logarithmic"
Biophys J, 76, 1310-1319, (1999). DOI:10.1016/S0006-3495(99)77293-0., Pubmed-ID: 10049314
 

Althaus, H. H. , Hempel, R., Klöppner, S., Engel, J., Schmidt-Schultz, T., Kruska, L., Heumann, R.
"Nerve growth factor signal transduction in mature pig oligodendrocytes"
J Neurosci Res, 50, 729-742, (1997). DOI:10.1002/(SICI)1097-4547(19971201)50:5<729::AID-JNR10>3.0.CO;2-X., Pubmed-ID: 9418961
 

Engel, J., Rabba, J., Schild, D.
"A transient, RCK4-like K+ current in cultured Xenopus olfactory bulb neurons"
Pflugers Arch, 432, 845-852, (1996). DOI:10.1007/s004240050207., Pubmed-ID: 8772135
 

Jung, A., Lischka, F.W., Engel, J., Schild, D.
"Sodium/calcium exchanger in olfactory receptor neurones of Xenopus laevis"
Neuroreport, 5, 1741-1744, (1994). DOI:10.1097/00001756-199409080-00013., Pubmed-ID: 7827321
 

Engel, J., Althaus, H.H., Kristjansson, G.I.
"NGF increases [Ca2+]i in regenerating mature oligodendroglial cells"
Neuroreport, 5, 397-400, (1994). DOI:10.1097/00001756-199401120-00006., Pubmed-ID: 8003662
 

Engel, J., Donath, E.
"Osmotic lysis of chromaffin granules treated with the ionophores nigericin and A23187 in isotonic sucrose solution at low pH"
Biochim Biophys Acta, 1064, 155-161, (1991). DOI:10.1016/0005-2736(91)90422-5., Pubmed-ID: 2025634
 

Engel, J., Pastushenko, V.F., Richter, W., Donath, E.
"On the interaction between chromaffin granule membranes and intragranular vesicles--theory and analysis of freeze-fracture micrographs"
Biorheology, 28, 75-87, (1991). DOI:10.3233/bir-1991-281-208., Pubmed-ID: 2049534
 

Engel, J., Ermakov, Y.A., Richter, W., Donath, E.
"Two different types of lysis of chromaffin granules characterised by freeze-fracture electron microscopy and photon correlation spectroscopy"
Biochim Biophys Acta, 1028, 236-244, (1990). DOI:10.1016/0005-2736(90)90172-k., Pubmed-ID: 2223797
 

Engel, J., Donath, E., Ermakov, Y.A., Meyer, H.W., Richter, W.
"Hyperosmotic relaxation lysis of chromaffin granules is caused by interactions between the granular membrane and intragranular vesicles"
Biochim Biophys Acta, 985, 111-119, (1989). DOI:10.1016/0005-2736(89)90354-4.