Ph.D. POSITION

to  study  the

MOLECULAR MECHANISMS

of

NEUROTRANSMITTER RELEASE

 

A Ph.D. position is available to study the molecular mechanisms that mediate neuronal exocytosis. 

The challenge is to define the molecular events that couple Ca2+ signaling to fusion of synaptic vesicles with the plasma membrane. We are addressing this issue using state-of-the-art electrophysiological methods (carbon fiber amperometry and membrane capacitance measurements), imaging techniques (Fura measurements, photolytic ‘uncaging’ of Ca2+, confocal microscopy, structured illumination and STED microscopy) and mice strains that are genetically deficient for synaptic proteins in order to discover, characterize, and disrupt protein-protein interactions that operate in excitation-secretion coupling. The work is directly supported by technical personel and applicants are given the opportunity to extend their research interest internationally through project–oriented collaborations.

Applicants with experience in electrophysiology, molecular biology, fluorescence spectroscopy are especially encouraged to apply.

 Please send your application including curriculum vitae, list of publications and a brief statement of research interest to: Prof. Dr. Dieter Bruns, Dept. of Physiology, University of Saarland, 66424 Homburg, Geb. 48, CIPMM, Germany. Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Selected readings:

Dhara M, Yarzagaravy A, Makke M, Schindeldecker B, Schwarz Y, Shaaban A, Sharma S, Böckmann RA, Lindau M, Mohrmann R, Bruns D (2016) v-SNARE transmembrane domains function as catalysts for vesicle fusion. Elife 5, e17571.

Mohrmann R, Dhara M, Bruns D (2015) Complexins: small but capable. Cell Moll Life Sci, 72, 4221-35.

Kesavan, J., Borisovska, M. and Bruns, D. (2007). v-SNARE actions during Ca2+-triggered exocytosis. Cell, 131, 351-263.

  

Mailing address

Prof. Dr. Dieter Bruns

Dept. Molecular Physiology

Center for Integrated Physiology and Molecular Medicine (CIPMM)

University of Saarland

66424 Homburg/Saar

Germany

TEL: +49 6841-1616495

TEL: +49 6841-1616494 (Secretary M. Wirth)

FAX: +49 6841-1616492

E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

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